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Using the Health and Retirement Study (HRS), investigators tested whether CMV infection and GrimAge, an epigenetic clock, accounted for associations between education level and comorbidity index and muscle weakness in 1,337 survivors. In models adjusted for covariates, CMV and GrimAge_r each explained measurable portions of the education–comorbidity link, while mediation for muscle weakness was not supported.",{"@graph":14,"@context":76},[15,34,55],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & 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question does the study address about cancer survivors?","Question",{"text":62,"@type":63},"The study examines whether CMV infection and GrimAge mediate the association between education level and health outcomes in cancer survivors, focusing on comorbidity index and muscle weakness.","Answer",{"name":65,"@type":60,"acceptedAnswer":66},"How were CMV infection and GrimAge assessed in the analysis?",{"text":67,"@type":63},"CMV infection was measured using CMV Immunoglobulin G antibody levels from blood samples, and GrimAge was calculated for a subset of survivors and decomposed into GrimAge_r to represent effects independent of chronological age.",{"name":69,"@type":60,"acceptedAnswer":70},"What did the results show regarding mediation for comorbidity index?",{"text":71,"@type":63},"In covariate-adjusted structural equation models, CMV infection explained 10.2% (p=0.03) and GrimAge_r explained 18.9% (p=0.01) of the education–comorbidity association.",{"name":73,"@type":60,"acceptedAnswer":74},"Did CMV infection or GrimAge mediate muscle weakness?",{"text":75,"@type":63},"Neither CMV infection nor GrimAge_r mediated the education–muscle weakness association, with the study noting limited sample size.","https://schema.org",{"og:url":32,"og:type":78,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":80,"canonical":32},"index,follow",{"doc_id":82,"site_id":7},426827,1791246233,{"code":4,"msg":85,"data":86},"success",[87,91,95,99,104,109,114,118,123,126,130],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":88,"show_sort_weight":89,"slug":90},"Story & 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\nGRIMAGE IN THE ASSOCIATION OF EDUCATION  \nWITH HEALTH OUTCOMES IN CANCER SURVIVORS  \nShuo Wang, Weihua Guan, Heather Nelson,  \nBharat Thyagarajan, Susan Everson-Rose, Anne Blaes, and Anna Prizment, University of Minnesota, Minneapolis, Minnesota, United States  \nCancer survivors with lower education experience a disproportionate burden of health outcomes. These health disparities may be partially explained by cytomegalovirus (CMV) infection and aging biomarkers. In the Health and Retirement Study (HRS)  \n– a nationally representative cohort of older adults, we examined whether CMV infection and GrimAge, an epigenetic clock, explained the associations of education (\u003C high school vs. ≥highschool) with comorbidity index and muscle weakness. HRS measured CMV Immunoglobulin G antibody levels in blood samples from 1,337 cancer survivors in 2016 (mean age=72 years, 54% female, 16% Non-white). A comorbidity index was constructed using five conditions (hypertension, lung disease, cardiac disorders, stroke, diabetes), and muscle weakness was assessed using grip strength in the dominant hand for these survivors.  \nAdditionally, GrimAge was calculated for 574 of the survivors.  \nWe calculated age acceleration for GrimAge as residuals after regressing GrimAge on chronological age to capture its effect independent of age (GrimAge_r). All analyses were adjusted for survey weights to generate nationally representative estimates.  \nIn the structural equation model adjusted for age, sex, race, BMI, and smoking, CMV infection explained 10.2%(p = 0.03) of the association between education and comorbidity index (total effect=0.30, p \u003C 0.01) . GrimAge_r explained 18.9%(p = 0.01) of the association between education and comorbidity index (total effect=0.41, p \u003C 0.01) . Neither CMV infection nor GrimAge_r mediated the association between education and muscle weakness; however, the sample size was limited. Our findings suggest that CMV infection and epigenetic clocks may mediate the association between education and health outcomes in cancer survivors.","cbCaijH3zMYoxxhJ","https://ap.wps.com/l/cbCaijH3zMYoxxhJ","pdf",47263,"English","# Study Objective\n## Data Source and Participants\n## Measures: CMV, GrimAge, Comorbidity, Muscle Weakness\n# Statistical Approach\n## Structural Equation Modeling\n## Mediation Results\n# Conclusions","[{\"question\":\"What question does the study address about cancer survivors?\",\"answer\":\"The study examines whether CMV infection and GrimAge mediate the association between education level and health outcomes in cancer survivors, focusing on comorbidity index and muscle weakness.\"},{\"question\":\"How were CMV infection and GrimAge assessed in the analysis?\",\"answer\":\"CMV infection was measured using CMV Immunoglobulin G antibody levels from blood samples, and GrimAge was calculated for a subset of survivors and decomposed into GrimAge_r to represent effects independent of chronological age.\"},{\"question\":\"What did the results show regarding mediation for comorbidity index?\",\"answer\":\"In covariate-adjusted structural equation models, CMV infection explained 10.2% (p=0.03) and GrimAge_r explained 18.9% (p=0.01) of the education–comorbidity association.\"},{\"question\":\"Did CMV infection or GrimAge mediate muscle weakness?\",\"answer\":\"Neither CMV infection nor GrimAge_r mediated the education–muscle weakness association, with the study noting limited sample size.\"}]","MEDIATING ROLE OF CMV INFECTION AND GRIMAGE IN THE ASSOCIATION OF EDUCATION WITH HEALTH OUTCOMES IN CANCER SURVIVORS | PDF",1790641952]