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This study examines sno-circCNOT1, a mechanosensitive snoRNA-like circular RNA, and tests its function in endothelial cells and ApoE-/- mice. High-throughput sequencing and functional assays show that sno-circCNOT1 modulates endothelial pyroptosis and inflammation, aggravating atherogenesis via the LMNA/METTL14/NLRP3 axis.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/mechanosensitive-snorna-like-circular-rna-snocirccnot1-drives-endothelial-dysfunction-and-atherosclerosis/453595/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/mechanosensitive-snorna-like-circular-rna-snocirccnot1-drives-endothelial-dysfunction-and-atherosclerosis/453595.png","ImageObject",300,407,{"name":92,"@type":93},"Riley","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the biological focus of this research?","Question",{"text":112,"@type":113},"The study focuses on sno-circCNOT1, a mechanosensitive snoRNA-like circular RNA, and how it influences endothelial dysfunction and atherosclerosis through inflammatory pathways.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How does sno-circCNOT1 respond to different shear stress patterns?",{"text":117,"@type":113},"Its expression increases with pro-atherogenic interleukin-1β and pathological oscillatory shear stress, while it decreases under laminar shear stress.",{"name":119,"@type":110,"acceptedAnswer":120},"What mechanistic pathway does the paper propose?",{"text":121,"@type":113},"sno-circCNOT1 binds lamin A/C (LMNA), stabilizes it, and facilitates an interaction involving METTL14-N, leading to NLRP3 activation and amplified endothelial inflammation.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},453595,1790812036,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":56,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144,"preview_page_count":4},1374391975076,"https://ap-avatar.wpscdn.com/avatar/14000253ca4ec9f6853?x-image-process=image/resize,m_fixed,w_180,h_180&k=1783305029341752051","Theranostics 2026, Vol. 16, Issue 6  \nIvyspring  \nInternational Publisher  \n2665  \nTheranostics  \n2026; 16(6): 2665-2683. doi: 10.7150/thno.122995  \nResearch Paper  \nMechanosensitive snoRNA-like circular RNA snocircCNOT1 drives endothelial dysfunction and atherosclerosis  \nLianru Bi1,3\\#, Yihao Zhu2,3\\#, Ziqi Chen1,3\\#, Yiying Yang1,3, Yanlong Leng1, Huijie Wang1,3, Jiajie Pan1,3, Xiaozhe Zhang1,3, Zekai Zeng1,3, Yunjun Liang3,5, Guifu Wu1,3,4􀀍, Wendong Fan2,3􀀍  \n1. Department of Cardiology, the Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, 518033, Guangdong, People's Republic of China.  \n2. Department of Cardiology, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510080, Guangdong, People's Republic of China.  \n3. NHC Key Laboratory of Assisted Circulation and Vascular Diseases, Sun Yat-sen University, Guangzhou, 510080, Guangdong, People's Republic of China.  \n4. Guangdong Innovative Engineering and Technology Research Center for Assisted Circulation, Shenzhen, Guangdong, People's Republic of China.  \n5. MOE Key Laboratory of Laser Life Science & Guangdong Provincial Key Laboratory of Life Science, College of Biophotonics, School of Optoelectronic Science and Engineering, South China Normal University, Guangzhou, 510631, Guangdong, People's Republic of China.  \n\\#These authors contributed equally to this work.  \n􀀍 Corresponding authors: Wendong Fan ([fanwd3@mail.sysu.edu.cn](fanwd3@mail.sysu.edu.cn)), PhD. Department of Cardiology, the First Affiliated Hospital of Sun Yat-sen University, No.58, Zhongshan 2nd Road, Guangzhou 510080, Guangdong Province, P.R. China. Tel: +86 20 87330396; Fax: +86 20 87330396. Guifu Wu ([wuguifu@mail.sysu.edu.cn](wuguifu@mail.sysu.edu.cn)), PhD. Department of Cardiology, the Eighth Affiliated Hospital of Sun Yat-sen University, No. 3025 Shennan Zhong Road, Shenzhen, 518033, Guangdong, P.R. China. Tel: +86 0755-83982222; Fax: +86 0755-83980805.  \n© The author(s). This is an open access article distributed under the terms of the Creative Commons Attribution License ([https://creativecommons.org/licenses/by/4.0/](https://creativecommons.org/licenses/by/4.0/)). See [https://ivyspring.com/terms](https://ivyspring.com/terms) for full terms and conditions.  \nReceived: 2025.08.03; Accepted: 2025.11.17; Published: 2026.01.01  \nAbstract  \nRationale: Hemodynamic shear stress critically influences atherosclerosis progression, yet the molecular mechanisms linking biomechanical stimuli to endothelial activation and vascular pathology remain poorly understood. While circular RNAs (circRNAs) participate in endothelial mechanotransduction, the role of mechanosensitive small nucleolar RNA (snoRNA)-like circRNA—a unique subclass harboring snoRNA sequences—in atherosclerosis is unexplored.  \nMethods: We characterized sno-circCNOT1 using high-throughput RNA sequencing, RNA interference, immunofluorescence, and co-immunoprecipitation. Functional studies were performed in endothelial cells and ApoE ⁻/ ⁻ mice to assess its role in pyroptosis and atherogenesis. Mechanistic investigations included RNA pull-down, mass spectrometry, and gain- and loss-of-function assays to identify sno-circCNOT1-interacting proteins and downstream signaling.  \nResults: We identified sno-circCNOT1, a circular RNA derived from CNOT1 exon 17 and intron 17, which incorporates snoRNASNORA50A. Its expression was upregulated by pro-atherogenic interleukin-1β and pathological oscillatory shear stress, but downregulated by laminar shear stress. Functionally, sno-circCNOT1 mediated shear stress-dependent regulation of endothelial pyroptosis and inflammation. Endothelial-specific overexpression of sno-circCNOT1 aggravated atherosclerotic lesion formation in ApoE ⁻/ ⁻ mice. Mechanistically, its snoRNA-like motif was essential for nuclear localization and function. sno-circCNOT1 bound the IF-ROD domain of lamin A/C (LMNA), stabilizing LMNA and facilitating its interaction with the N-terminal domain of methyltransfe","cbCaigfneORnodAn","https://ap.wps.com/l/cbCaigfneORnodAn","pdf",13627605,"English","# Abstract\n## Rationale\n## Methods\n## Results\n## Conclusions\n# Introduction\n## Hemodynamic shear stress and endothelial pyroptosis\n## Circular RNAs and mechanotransduction","[{\"question\":\"What is the biological focus of this research?\",\"answer\":\"The study focuses on sno-circCNOT1, a mechanosensitive snoRNA-like circular RNA, and how it influences endothelial dysfunction and atherosclerosis through inflammatory pathways.\"},{\"question\":\"How does sno-circCNOT1 respond to different shear stress patterns?\",\"answer\":\"Its expression increases with pro-atherogenic interleukin-1β and pathological oscillatory shear stress, while it decreases under laminar shear stress.\"},{\"question\":\"What mechanistic pathway does the paper propose?\",\"answer\":\"sno-circCNOT1 binds lamin A/C (LMNA), stabilizes it, and facilitates an interaction involving METTL14-N, leading to NLRP3 activation and amplified endothelial inflammation.\"}]","Mechanosensitive snoRNA-like circular RNA snocircCNOT1 drives endothelial dysfunction and atherosclerosis | PDF",1790739202,48]