[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-328698-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-328698-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","mechanisms-of-crosstalk-between-the-oropharyngeal-microbiome-and-human-papillomavirus-in-oropharyngeal-carcinogenesis-mini-review","Mechanisms of crosstalk between the oropharyngeal microbiome and human papillomavirus in oropharyngeal carcinogenesis - mini review","","Head and neck squamous cell carcinoma (HNSCC) is a leading global cancer, and rising HPV-positive oropharyngeal squamous cell carcinoma (OPSCC) accounts for about 70% of cases. Persistent high-risk HPV infection is linked to cancer but is not sufficient by itself, indicating roles for host factors. Next-generation sequencing has advanced understanding of microbiome changes in cancerous environments, yet the specific impact of HPV–microbiome crosstalk in HPV-positive OPSCC remains limited. This mini review summarizes current knowledge on the oropharyngeal microbiome, compositional shifts in HPV-positive OPSCC, and proposed mechanisms linking HPV and microorganisms to carcinogenesis, emphasizing the need for further research on cancer development and progression.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/mechanisms-of-crosstalk-between-the-oropharyngeal-microbiome-and-human-papillomavirus-in-oropharyngeal-carcinogenesis-mini-review/328698/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/mechanisms-of-crosstalk-between-the-oropharyngeal-microbiome-and-human-papillomavirus-in-oropharyngeal-carcinogenesis-mini-review/328698.png","ImageObject",300,407,{"name":42,"@type":43},"Asher","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-26","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",7,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"Why is HPV not sufficient to cause oropharyngeal cancer?","Question",{"text":63,"@type":64},"Most HPV infections clear, and only a minority persist. Persistent high-risk HPV is associated with cancers, but HPV alone does not provide enough to trigger carcinogenesis.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"What role do microbiome changes play in HPV-positive OPSCC?",{"text":68,"@type":64},"Sequencing studies show that disruptions to the oral/oropharyngeal microbiome can create inflammatory conditions with carcinogenic potential. The review focuses on compositional shifts in the oropharyngeal microbiome in HPV-positive OPSCC.",{"name":70,"@type":61,"acceptedAnswer":71},"What does the mini review cover regarding HPV–microbiome crosstalk?",{"text":72,"@type":64},"It examines what is known about the oropharyngeal microbiome in HPV-positive OPSCC and reviews potential mechanisms by which HPV may interact with specific microorganisms to contribute to carcinogenesis.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},328698,1790729861,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":107,"show_sort_weight":108,"slug":109},"Healthcare",40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":112,"slug":113},8,30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":111,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":139,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":145,"preview_page_count":4},687197207639,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","TYPE Mini Review  \nPUBLISHED 15 August 2024  \nDOI 10.3389/fonc.2024.1425545  \nOPEN ACCESS  \nEDITED BY  \nAnastasios Maniakas,  \nUniversity of Texas MD Anderson Cancer Center, United States  \nREVIEWED BY Bhaskar Roy,  \nChinese Academy of Sciences, China Theresa Guo,  \nUniversity of California, San Diego, United States  \n*CORRESPONDENCE Albert Y. Han  \n [albert.han@med.usc.edu](albert.han@med.usc.edu)  \nRECEIVED 30 April 2024  \nACCEPTED 24 June 2024  \nPUBLISHED 15 August 2024  \nCITATION  \nChung RS, Wong S, Lin D, Kokot NC,  \nSinha UK and Han AY (2024) Mechanisms of crosstalk between the oropharyngeal microbiome and human papillomavirus in oropharyngeal carcinogenesis: a mini review.  \nFront. Oncol. 14:1425545 .  \ndoi: 10.3389/fonc.2024.1425545  \nCOPYRIGHT  \n© 2024 Chung, Wong, Lin, Kokot, Sinha and Han. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nMechanisms of crosstalk between the oropharyngeal microbiome and human papillomavirus in oropharyngeal carcinogenesis: a mini review  \nRyan S. Chung, Stephanie Wong, Dechen Lin, Niels C. Kokot, Uttam K. Sinha and Albert Y. Han*  \nDepartment of Otolaryngology—Head and Neck Surgery, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, United States  \nHead and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer globally. Notably, human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) is on the rise, accounting for 70% of all OPSCC cases. Persistent high-risk HPV infection is linked to various cancers, but HPV infection alone is not sufficient to cause cancer. Advances in next-generation sequencing have improved our understanding of changes in the human microbiome of cancerous environments . Yet, there remains a dearth of knowledge on the impact of HPV-microbiome crosstalk in HPV-positive OPSCC. In this review, we examine what is known about the oropharyngeal microbiome and the compositional shifts in this microbiome in HPV-positive OPSCC. We also review potential mechanisms of crosstalk between HPV and specific microorganisms. Additional research is needed to understand these interactions and their roles on cancer development and progression.  \nKEYWORDS  \noropharyngeal cancer, HPV, microbiome, crosstalk, carcinogenesis  \nHighlights  \nHead and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer globally. Notably, human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) is on the rise, accounting for 70% of all OPSCC cases. Persistent highrisk HPV infection is linked to various cancers, but HPV infection alone is not sufficient to cause cancer. Additional factors such as chronic inflammation, immune deficiency, and host microbiome alterations may contribute to cancer development. Recent advances in nextgeneration sequencing have improved our understanding of the role of human microbiome in cancer. This review focuses on the unique features of the oropharyngeal microbiome and its interaction with HPV in carcinogenesis. It highlights the distinct differences between the oral and oropharyngeal microbiomes and the compositional shifts in the microbiome of HPVpositive OPSCC. The review proposes potential mechanisms of HPV-microbiome crosstalk contributing to carcinogenesis, emphasizing the need for further research to understand these interactions and their impact on cancer development and progression.  \nFrontiers in Oncology 01 [frontiersin.org](frontiersin.org)  \nIntroduction  \nWhile the overall incidence of head and neck squamous cell carcinoma (HNSCC) is declining globally, human pap","cbCaioxwjwFnwtuh","https://ap.wps.com/l/cbCaioxwjwFnwtuh","pdf",1637181,11,"English","# Introduction\n## HPV-positive OPSCC epidemiology and persistence\n## Microbiome characterization via next-generation sequencing\n# Orpharyngeal microbiome and compositional shifts in HPV-positive OPSCC\n# Proposed mechanisms of HPV–microbiome crosstalk\n# Summary and research needs","[{\"question\":\"Why is HPV not sufficient to cause oropharyngeal cancer?\",\"answer\":\"Most HPV infections clear, and only a minority persist. Persistent high-risk HPV is associated with cancers, but HPV alone does not provide enough to trigger carcinogenesis.\"},{\"question\":\"What role do microbiome changes play in HPV-positive OPSCC?\",\"answer\":\"Sequencing studies show that disruptions to the oral/oropharyngeal microbiome can create inflammatory conditions with carcinogenic potential. The review focuses on compositional shifts in the oropharyngeal microbiome in HPV-positive OPSCC.\"},{\"question\":\"What does the mini review cover regarding HPV–microbiome crosstalk?\",\"answer\":\"It examines what is known about the oropharyngeal microbiome in HPV-positive OPSCC and reviews potential mechanisms by which HPV may interact with specific microorganisms to contribute to carcinogenesis.\"}]","Mechanisms of crosstalk between the oropharyngeal microbiome and human papillomavirus in oropharyngeal carcinogenesis - mini review | PDF",1789980617,28]