[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-330042-105":59,"doc-detail-330042-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","mechanisms-of-cancer-cell-death-induction-by-triptolide-a-comprehensive-overview","Mechanisms of cancer cell death induction by triptolide - A comprehensive overview","","Cancer incidence and treatment-associated toxicities drive renewed interest in naturally derived constituents. Triptolide, the principal active component of Tripterygium wilfordii, is reviewed for its mechanisms and therapeutic potential across diverse tumors. Evidence links triptolide to cancer-cell death through apoptosis induction, including HSP70 inhibition and P21 upregulation affecting CDKs, alongside additional targets such as MKP1, histone methyltransferases, and RNA polymerases. The review also covers autophagy, AKT signaling, multiple targeted-protein pathways, synergy with chemotherapeutics, and triptolide derivatives (e.g., minnelide, LLDT8) and delivery strategies using conjugates or nano-carriers.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/mechanisms-of-cancer-cell-death-induction-by-triptolide-a-comprehensive-overview/330042/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/mechanisms-of-cancer-cell-death-induction-by-triptolide-a-comprehensive-overview/330042.png","ImageObject",300,407,{"name":92,"@type":93},"Logic","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-31","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What biological process does triptolide mainly induce in cancer cells according to the abstract?","Question",{"text":112,"@type":113},"The abstract states that triptolide triggers cancer-cell death by inducing cellular apoptosis.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which molecular factors are mentioned as targets or regulators related to triptolide?",{"text":117,"@type":113},"It highlights inhibition of HSP70 and upregulation of P21, and also lists additional potential targets such as MKP1, histone methyltransferases, and RNA polymerases.",{"name":119,"@type":110,"acceptedAnswer":120},"How does the document describe triptolide’s role in cancer therapy beyond apoptosis?",{"text":121,"@type":113},"It notes involvement of autophagy and AKT signaling, additional protein-targeted pathways, improved effectiveness of various chemotherapeutics, and advances in triptolide derivatives and targeted delivery strategies.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},330042,1790125955,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":36,"preview_page_count":4},1099513958762,"https://ap-avatar.wpscdn.com/avatar/1000023916a998db790?x-image-process=image/resize,m_fixed,w_180,h_180&k=1784791008015729253","Heliyon 10 (2024) e24335  \nContents lists available at ScienceDirect  \nHeliyon  \njournal [homepage:](homepage: www.cell.com/heliyon)[ www.cell.com/heliyon](homepage: www.cell.com/heliyon)  \n| Review article\u003Cbr>Mechanisms of cancer cell death induction by triptolide: A comprehensive overview\u003Cbr>Ke Feng a, Xiaojiang Lia, Yuzhuo Bai b, Dawei Zhang c, Lin Tiand, *\u003Cbr>a Department of General Surgery, Affiliated Hospital of Changchun University of Traditional Chinese Medicine, Changchun, 130000, China b Department of Breast and Thyroid Surgery Affiliated Hospital of Changchun University of Traditional Chinese Medicine, Changchun, 130000, China\u003Cbr>c Department of General Surgery Baishan Hospital of Traditional Chinese Medicine, Baishan, 134300, China\u003Cbr>d Department of Lung Oncology, Affiliated Hospital of Changchun University of Traditional Chinese Medicine, Changchun, 130000, China |  |  |\n| --- | --- | --- |\n| A R T I C L E I N F O |  | A B S T R A C T |\n| Keywords:\u003Cbr>Triptolide\u003Cbr>Cancer mechanisms Apoptosis Targeting\u003Cbr>Anti-tumor |  | The need for naturally occurring constituents is driven by the rise in the cancer prevalence and the unpleasant side effects associated with chemotherapeutics. Triptolide, the primary active component of “Tripterygium Wilfordii”, has exploited for biological mechanisms and therapeutic potential against various tumors. Based on the recent pre-clinical investigations, triptolide is linked to the induction of death of cancerous cells by triggering cellular apoptosis via inhibiting heat shock protein expression (HSP70), and cyclin dependent kinase (CDKs) by up regulating expression of P21. MKP1, histone methyl transferases and RNA polymerases have all recently identified as potential targets of triptolide in cells. Autophagy, AKT signaling pathway and various pathways involving targeted proteins such as A-disintegrin & metalloprotease-10 (ADAM10), Polycystin-2 (PC-2), dCTP pyro-phosphatase 1 (DCTP1), peroxiredoxin-I (Prx-I), TAK1 binding protein (TAB1), kinase subunit (DNA–PKcs) and the xeroderma-pigmentosum B (XPB or ERCC3) have been exploited. Besides that, triptolide is responsible for enhancing the effectiveness of various chemotherapeutics. In addition, several triptolide moieties, including minnelide and LLDT8, have progressed in investigations on humans for the treatment of cancer. Targeted strategies, such as triptolide conjugation with ligands or triptolide loaded nano-carriers, are efficient techniques to confront toxicities associated with triptolide. We expect and anticipate that advances in near future, regarding combination therapies of triptolide, might be beneficial against cancerous cells. |\n\n1. Introduction  \nWith more than 2.6 million new cases each year, cancer poses a serious risk to the general population and is second largest cause of death worldwide [1]. According to research, a large number of genes that code for proteins like, growth-factor receptors, tumor-suppressors, growth-factors, transcription-factors and anti-apoptotic proteins are dysfunctional in the majority of malignancies. These proteins are all potential targets for cancer treatment [2]. The need for naturally occurring constituents is driven by the rise in the cancer prevalence and the unpleasant side effects associated with chemotherapeutics. In contrast, the idea of using organic components to prevent cancer is becoming prevalent, particularly since conventional targeted therapies already had limited  \n* Corresponding author.  \nE-mail address: [fztianlin@sina.com](fztianlin@sina.com) (L. Tian).  \n[https://doi.org/10.1016/j.heliyon.2024.e24335](https://doi.org/10.1016/j.heliyon.2024.e24335)  \nReceived 23 May 2023; Received in revised form 6 January 2024; Accepted 8 January 2024 Available online 10 January 2024  \n2405-8440/© 2024 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license ([http://creativecommons.org/licenses/by/4.0/](http://creativecommons.org/licenses/by/4.0","cbCainwwpplQcOaY","https://ap.wps.com/l/cbCainwwpplQcOaY","pdf",2088862,16,"English","# Introduction\n## Background on cancer burden and molecular targets\n## Role of phytochemicals and traditional medicines\n## Focus on non-apoptotic death pathways\n# Overview of triptolide and mechanisms (from abstract)","[{\"question\":\"What biological process does triptolide mainly induce in cancer cells according to the abstract?\",\"answer\":\"The abstract states that triptolide triggers cancer-cell death by inducing cellular apoptosis.\"},{\"question\":\"Which molecular factors are mentioned as targets or regulators related to triptolide?\",\"answer\":\"It highlights inhibition of HSP70 and upregulation of P21, and also lists additional potential targets such as MKP1, histone methyltransferases, and RNA polymerases.\"},{\"question\":\"How does the document describe triptolide’s role in cancer therapy beyond apoptosis?\",\"answer\":\"It notes involvement of autophagy and AKT signaling, additional protein-targeted pathways, improved effectiveness of various chemotherapeutics, and advances in triptolide derivatives and targeted delivery strategies.\"}]","Mechanisms of cancer cell death induction by triptolide - A comprehensive overview | PDF",1789986675]