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Anoctamin-1 (ANO1), a calcium-activated chloride channel component (CaCC), is broadly expressed in epithelial, vascular smooth muscle, and tumor cells and is linked to proliferation and migration. However, the precise pathways connecting ANO1 to malignant transformation and immune responses are not fully defined. This review summarizes ANO1 regulatory functions and evaluates its potential as a therapeutic target for GI cancer diagnosis and treatment improvements.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/mechanism-of-action-and-therapeutic-value-of-anoctamin-1-in-gastrointestinal-cancers-review/370551/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/mechanism-of-action-and-therapeutic-value-of-anoctamin-1-in-gastrointestinal-cancers-review/370551.png","ImageObject",300,407,{"name":92,"@type":93},"Maya Linwood","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",12,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What is anoctamin-1 (ANO1) and where is it mainly expressed?","Question",{"text":113,"@type":114},"ANO1 is a member of the calcium-activated chloride channel family and is primarily localized to the plasma membrane. It is expressed across multiple cell types, including epithelial cells, vascular smooth muscle cells, and tumor cells.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"Why is ANO1 considered a potential therapeutic target in gastrointestinal cancers?",{"text":118,"@type":114},"ANO1 influences cell proliferation and migration and is implicated in biological processes tied to malignancies. Targeting ANO1 pathways is proposed as an effective treatment strategy for GI cancers.",{"name":120,"@type":111,"acceptedAnswer":121},"What major obstacles limit current GI cancer therapies?",{"text":122,"@type":114},"GI cancer treatment faces challenges such as recurrence, metastasis, and drug resistance. 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Immunol. 16:1599100 .  \ndoi: 10.3389/fimmu.2025.1599100  \nCOPYRIGHT  \n© 2025 Zhang, Lin, Xu, Zhou, Mu, Shi and Lv. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nMechanism of action and therapeutic value of anoctamin-1 in gastrointestinal cancers  \nXiaoyue Zhang 1†, Jie Lin 2†, Hongpan Xu 3, Yan Zhou 2, Zhiyi Mu 1, Ruizhe Shi 2* and Yalei Lv 1*  \n1Oncology Department 4, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, China, 2 Department of Gastrointestinal Disease Center, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, China, 3 Department of Health Management Center, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, China  \nGastrointestinal (GI) cancers are main causes of poor health, with most remaining difficult to treat effectively. Identifying new targets for treatment is crucial for improving the efficacy of tumour therapies and enhancing patient quality of life. Anoctamin-1 (ANO1), a crucial component of calcium-activated chloride channels (CaCCs), is expressed widely in various cell types, including epithelial cells, vascular smooth muscle cells, and tumour cells, and influences cell proliferation and migration. Nonetheless, the exact pathways through which ANO1 contributes to malignant transformation and immune responses remain elusive. This review comprehensively examines the regulatory functions and potential therapeutic applications of ANO1 in GI cancers. The goal of this work is to offer new perspectives for further study on the role of ANO1 in gastrointestinal cancers and to support improvements in therapeutic strategies for cancer diagnosis and treatment through the targeting of ANO1 .  \nKEYWORDS  \nanoctamin-1, gastrointestinal cancers, mechanism, therapy, prognosis  \n1 Introduction  \nThe treatment of gastrointestinal (GI) cancers has long been significant subjects in medical research. Important progress has been made in treating GI cancers through advances in medical technology and research. However, the complex and variable pathogenesis of tumours creates challenges such as recurrence, metastasis, and drug resistance, which pose major threats to human health (1, 2) . Data from the International Agency for Research on Cancer revealed that the global incidence of cancer was approximately 20 million cases, with 9.7 million fatalities in 2022 . Colorectal cancer is the most common and the most fatal GI cancer, accounting for 9.6% of all cancers and 9.3% of all cancer-related deaths, followed by cancers of the stomach, liver, oesophagus, and pancreas (3) .  \nThe treatment of GI cancers typically involves surgery, chemotherapy, radiotherapy, targeted therapy, and immunotherapy (4–6) . However, patients may respond differently to  \nFrontiers in Immunology 01 [frontiersin.org](frontiersin.org)  \ntreatments due t","cbCaiqCsIKcRLFB7","https://ap.wps.com/l/cbCaiqCsIKcRLFB7","pdf",4531981,11,"English","# Introduction\n## Challenges in GI cancer treatment\n## Targeted therapy limitations\n## Ion channels and CaCCs in cancer biology\n# ANO1 biology and relevance to GI cancers\n## ANO1 identity (ANO1/TMEM16A/DOG1)\n## Genomic location and membrane localization\n## Functions in chloride transport and cell regulation\n# ANO1 contributions to malignant progression\n## Regulation of signaling, proliferation, and secretion\n## Rationale for therapeutic targeting","[{\"question\":\"What is anoctamin-1 (ANO1) and where is it mainly expressed?\",\"answer\":\"ANO1 is a member of the calcium-activated chloride channel family and is primarily localized to the plasma membrane. It is expressed across multiple cell types, including epithelial cells, vascular smooth muscle cells, and tumor cells.\"},{\"question\":\"Why is ANO1 considered a potential therapeutic target in gastrointestinal cancers?\",\"answer\":\"ANO1 influences cell proliferation and migration and is implicated in biological processes tied to malignancies. Targeting ANO1 pathways is proposed as an effective treatment strategy for GI cancers.\"},{\"question\":\"What major obstacles limit current GI cancer therapies?\",\"answer\":\"GI cancer treatment faces challenges such as recurrence, metastasis, and drug resistance. Patients can also respond differently due to tumor heterogeneity, with adverse reactions including chemotherapy resistance and systemic toxicity.\"}]","Mechanism of action and therapeutic value of anoctamin-1 in gastrointestinal cancers - Review | PDF",1790189094,28]