[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-146198-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-146198-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","measurement-of-viscosity-of-adult-zebrafish-blood-using-a-capillary-pressure-driven-viscometer","Measurement of Viscosity of Adult Zebrafish Blood Using a Capillary Pressure-Driven Viscometer","","This paper introduces the first experimental method for measuring viscosity of adult zebrafish whole blood with a capillary pressure-driven microfluidic viscometer. Device calibration is performed using water, after which viscosity measurements of human whole blood match published reference data, confirming reliability. Power-law and Carreau–Yasuda models capture non-Newtonian shear-thinning behavior, enabling viscosity estimation across a wide shear-rate range within short measurement time and with very small sample volumes (down to ~1 μL).",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/measurement-of-viscosity-of-adult-zebrafish-blood-using-a-capillary-pressure-driven-viscometer/146198/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/measurement-of-viscosity-of-adult-zebrafish-blood-using-a-capillary-pressure-driven-viscometer/146198.png","ImageObject",300,407,{"name":42,"@type":43},"Ethan Miller","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-09-17","2026-08-26",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",6,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What device is used to measure adult zebrafish whole blood viscosity?","Question",{"text":63,"@type":64},"A capillary pressure-driven microfluidic viscometer is used to generate controlled flow conditions and obtain viscosity from the measured liquid motion inside a microchannel.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How is the method validated before zebrafish measurements?",{"text":68,"@type":64},"The viscometer is calibrated with water, and human whole blood viscosity is measured to show good agreement with published data, demonstrating device reliability.",{"name":70,"@type":61,"acceptedAnswer":71},"Which rheological models are applied to describe blood behavior?",{"text":72,"@type":64},"Power law and Carreau–Yasuda rheological models are used to model non-Newtonian (shear-thinning) behavior over a wide range of shear rates.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},146198,1787738290,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,105,110,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":102,"show_sort_weight":103,"slug":104},"Technology",50,"technology",{"id":106,"doc_module":4,"doc_module_name":25,"category_name":107,"show_sort_weight":108,"slug":109},7,"Healthcare",40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":112,"slug":113},8,30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":111,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":33,"language":139,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":12,"update_tm":80,"read_time":123},687207017582,"https://ap-avatar.wpscdn.com/davatar_994ba38a5ba835b3df7d355c54d3ed8d","W2P.044  \nMEASUREMENT OF VISCOSITY OF ADULT ZEBRAFISH BLOOD USING A CAPILLARY  \nPRESSURE-DRIVEN VISCOMETER  \nD. Kang1, W. Wang2, J. Lee3, Y.C. Tai1, and T. K. Hsiai3  \n1Department of Electrical Engineering, California Institute of Technology, Pasadena, USA 2Department of Electrical Engineering, Peking University, Beijing, China 3Department of Bioengineering, University of California Los Angeles, Los Angeles, USA  \nABSTRACT  \nThis paper presents the first experimental work on the viscosity measurement of adult zebrafish whole blood using a capillary pressure-driven microfluidic viscometer. After the device calibration with water, the viscosity measurement of human whole blood was performed and in good agreement with published data, demonstrating the reliability of the device. Power law and Carreau-Yasuda rheological models were used to model the non-Newtonian behaviors of the human and zebrafish blood. Theoretical modeling and numerical algorithms were applied to determine the blood viscosity over a wide range of shear rates. The proposed approach is uniquely applicable for small sample volume (down to 1µL or less), and short measurement time (\u003C3min) . A wide range of shear rates is produced in a single test.  \nKEYWORDS  \nCapillary pressure-driven viscometer, human whole blood, adult zebrafish whole blood, non-Newtonian viscosity, empirical power law model, Carreau-Yasuda rheological model  \nINTRODUCTION  \nRheological properties of blood play significant roles in the progression of coronary and peripheral vascular diseases [1] . Zebrafish is emerging as a more and more popular animal model for cardiovascular research. However, therheology of zebrafish whole blood remains unclear, and only“intelligent” estimate of blood viscosity of zebrafish from the particle volume fraction was used [2] . On the other hand, although conventional rotational and capillary viscometers allow detailed rheological analysis, they require relatively large sample volume (0.5-3mL) [3], and can not be used for zebrafish blood because only a few microliters of blood can be harvested from a zebrafish [4] . In addition, a fast MEMS oscillating micro-mechanical viscometer [5] has been designed for small sample volume, however, its viscosity measurement can only be produced at a specific shear rate atone time. Hence, it is not suitable for blood as anon-Newtonian fluid, for which the viscosity data over a wide range of shear rates are desired.  \nIn this study, a capillary pressure-driven viscometer was designed to demand small amount of samples (down to 1µLor less) and produce a wide range of shear rates in a single run for continuous viscosity measurements that simulated the physiological flow environment. This device also featured short measurement time (\u003C3min) and thus required no  \naddition of anti-coagulants which could alter the blood viscosity [6] . The device was made from PDMS, a widely studied structural material [7] for making microdevices [8, 9], as well as glass. The viscosity measurement of adult zebrafish whole blood was produced for the first time.  \nTHEORETICAL MODELING  \nThe complex constitution of blood renders it anon-Newtonian fluid, especially a shear-thinning or pseudoplastic fluid, which has a lower apparent viscosity at higher shear strain rates. A common empirical rheological model is the two-parameter power law model,  \n (1)  \nwhere η is the viscosity, ߛሶ is the shear rate, n is the power law exponent, and both m and n are constants.  \nFigure 1: The side view of the microfluidic channel as the capillary pressure-driven viscometer. The liquid column length L(t), the velocity distribution u(y,t), the mean liquid advancing velocity v(t), the channel height h, and the contact angle θ are indicated. The dotted arrow indicates the flow direction.  \nFor the plane Poiseuille flow inside a thin rectangular microchannel, the velocity field lies in the x direction and is a function of y alone (Figure 1), and the pressure gradient also lies in ","cbCaikZ5Z40NHMAt","https://ap.wps.com/l/cbCaikZ5Z40NHMAt","pdf",1364985,"English","# Abstract\n# Introduction\n# Theoretical Modeling\n## Power law model and governing relations","[{\"question\":\"What device is used to measure adult zebrafish whole blood viscosity?\",\"answer\":\"A capillary pressure-driven microfluidic viscometer is used to generate controlled flow conditions and obtain viscosity from the measured liquid motion inside a microchannel.\"},{\"question\":\"How is the method validated before zebrafish measurements?\",\"answer\":\"The viscometer is calibrated with water, and human whole blood viscosity is measured to show good agreement with published data, demonstrating device reliability.\"},{\"question\":\"Which rheological models are applied to describe blood behavior?\",\"answer\":\"Power law and Carreau–Yasuda rheological models are used to model non-Newtonian (shear-thinning) behavior over a wide range of shear rates.\"}]","Measurement of Viscosity of Adult Zebrafish Blood Using a Capillary Pressure-Driven Viscometer | PDF"]