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The empirical formula is derived from data collected from 122 adults and 80 children across several centers. Results are scaled to a standard adult surface area and expressed in mV min/1.73 m². Residual standard deviation values from single samples at 45 min (adults) and 35 min (pediatric) support accuracy, and the new clearance formula is recommended as a replacement with no loss of precision in adults.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/measurement-of-renal-function-with-technetium-99m-mag3-in-children-and-adults/474392/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/measurement-of-renal-function-with-technetium-99m-mag3-in-children-and-adults/474392.png","ImageObject",300,407,{"name":92,"@type":93},"AfterMidnight","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-08","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":14},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the proposed procedure for measuring 99mTc-MAG3 clearance?","Question",{"text":112,"@type":113},"It is a single-injection, single-sample technique that measures 99mTc-MAG3 clearance and incorporates scaling for patient size.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How does the method handle patients who are children versus adults?",{"text":117,"@type":113},"The clearance approach uses patient-size scaling based on an empirical dimensionless formula, avoiding the need for classification into child or adult groups.",{"name":119,"@type":110,"acceptedAnswer":120},"Why is the new clearance formula recommended?",{"text":121,"@type":113},"It is based on a larger and more diverse subject population and extends validity to children without reducing accuracy for adult measurements.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},474392,1790784084,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":14,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":29,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":129,"read_time":143,"preview_page_count":4},962090896061,"https://ap-avatar.wpscdn.com/davatar_9964176cb1d06d4a9deccf72a44ae3dc","2.Roswit B.White DC.Severe radiation injuries of the lung.AmJ Roentgen 1977;129:127-136.  \n3.Moss WT.Haddy FJ.Sweany SK.Some factors altering the severity of acute radiationpneumonitis:variation with cortisone.heparin,and antibiotics.Radiologv 1960;75:50-54.  \n4.Libshitz HI,Southard ME.Complications of radiation therapy:the thorax.SeminRoentgenol 1974;9:41-49.  \n5.Prato FS,Kurdyak R,Saibil EA,Rider WD,Aspin N.Physiological and radiographicassessment during the development of pulmonary radiation fibrosis.Radiologv1977;122:389-397.  \n6.Frolich D,Adler K,Gottschild D.Neumann G.The value of the pulmonary diffusingcapacity in comparison to perfusion scintigraphy of the lung in radiation pneumonitis.Z Erkr Amungsorgane 1989;173:170-173.  \n# Measurement of Renal Function withTechnetium-99m-MAG3 in Children and Adults\n\nCharles D.Russell,Andrew T.Taylor and Eva V.Dubovsky  \nDivision of Nuclear Medicine,University of Alabama Hospital and Nuclear Medicine Service,Department of Veterans AffairsMedical Center—Birmingham,Birmingham,Alabama;and Department of Nuclear Medicine,Emory University Hospital,Atlanta,Georgia  \nA single-injection,single-sample procedure for measuring 99mTc-MAG3 clearance is presented that incorporates scaling for patientsize and is valid for both children and adults.Methods:Theprocedure is based on an empirical formula in which all measure-ments are expressed in dimensionless combinations.The formulawas obtained by itting data collected from 122 adults and 80children at several centers.Results:All results were scaled tostandard adult surface area and are presented in units of mVmin/  \n1.73 m².For adult subjects,the residual standard deviation (r.s.d.)calculated from asingle sample at 45 min was found to be 23,usingthe plasma clearance calculated from a multi-sample clearancecurve as a reference.This did not differ significantly from the value of22 obtained with our previous formula,which was valid for adultsonly.For pediatric subjects,an r.s.d.of 24 was calculated by thenew formula from a single sample at 35 min;a comparable value of33 was found using a pediatric formula previously published.Conclusion:The new clearance formula is recommended as areplacement for the formula we previously published,since it isbased on a larger and more diverse subject population,and since itnow holds for children as well,with no loss of accuracy for adultsubjects.  \nKey Words:kidney;technetium-99m-MAG3;radionuclide clear-ance  \nJ Nucl Med 1996;37:588-593  \ntherapy.In addition,the findings of this study may also berelevant for the interpretation of 1'In-pentetreotide studies incancer patients investigated for tumor detection since irradiatedlung areas may produce false-positive results.  \n## ACKNOWLEDGEMENTS\n\nThe authors thank the technical staff ofthe nuclear medicine andaudiovisual departments of The Netherlands Cancer Institute fortechnical support and preparing the illustrations,and MallinkcrodtMedical B.V.for the generous supply of ''In-pentetreotide.  \n## REFERENCES\n\n1.Gross NJ.Pulmonary effects of radiation therapy.Ann Intern Med 1977;86:81-92.  \n10.Kataoka M.Kawamura M,Itoh H,Hamamoto K.Gallium-67-citrate scintigraphy forthe early detection of radiation pneumonitis.Clin Nucl Med 1992;17:27-31.  \n11.Rubin P,Finkelstein J.Shapiro D.Molecular biology mechanisms in the radiationinduction of pulmonary injury sindromes:inter-relationship between the alveolarmacrophage and the septal fibroblast.Int J Radiat Oncol Biol Phys 1992;24:93-101.  \n12.Krenning EP,Kwekkeboom DJ,Bakker WH,et al.Somatostatin receptor scintigraphywith [''In-DTPA-D-Phe']-and [¹²31-Tyr³]-octreotide:the Rotterdam experience withmore than 1000 patients.EurJ Nucl Med 1993;20:716-731.  \n13.Hoefnagel CA.MIBG and somatostatin in oncology:role in the management of neuralcrest tumours.EurJ Nucl Med 1993;21:561-581.  \n14.Vanhagen PM,Krenning EP,Reubi JC.et al.Somatostatin analogue scintigraphy ingranulomatous diseases.EurJ Nucl Med 1994;21:497-502.  \n15.Cosset JM,Henry-Amar ","cbCaildFzVXEK1yu","https://ap.wps.com/l/cbCaildFzVXEK1yu","pdf",1216929,"English","# Methods\n## Empirical scaling formula\n# Results\n## Adult and pediatric residual standard deviation\n# Conclusion\n## Recommended replacement formula\n# Acknowledgements\n# References","[{\"question\":\"What is the proposed procedure for measuring 99mTc-MAG3 clearance?\",\"answer\":\"It is a single-injection, single-sample technique that measures 99mTc-MAG3 clearance and incorporates scaling for patient size.\"},{\"question\":\"How does the method handle patients who are children versus adults?\",\"answer\":\"The clearance approach uses patient-size scaling based on an empirical dimensionless formula, avoiding the need for classification into child or adult groups.\"},{\"question\":\"Why is the new clearance formula recommended?\",\"answer\":\"It is based on a larger and more diverse subject population and extends validity to children without reducing accuracy for adult measurements.\"}]","Measurement of Renal Function with Technetium-99m-MAG3 in Children and Adults | PDF",15]