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Methods included retrospective analysis of patients treated with PRP for musculoskeletal conditions. Results: MPV was significantly lower in PRP than in blood, while intra-subject variability remained low. Coefficients of variation were 2.78% in blood and 3.87% in PRP, with greater variation in PRP. Conclusion: Centrifugation reduces MPV and protocol standardization supports consistent biological quality.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/mean-platelet-volume-in-blood-vs-platelet-rich-plasma-demographic-analysis-and-intrasubject-variability-in-prp-therapy/449289/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/mean-platelet-volume-in-blood-vs-platelet-rich-plasma-demographic-analysis-and-intrasubject-variability-in-prp-therapy/449289.png","ImageObject",300,407,{"name":92,"@type":93},"Aldword","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What was the study designed to evaluate regarding MPV?","Question",{"text":112,"@type":113},"The study evaluated inter- and intraindividual differences in mean platelet volume (MPV) between whole blood and platelet-rich plasma (PRP), and assessed the role of demographic factors such as sex, age, and BMI.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How did MPV in PRP compare with MPV in whole blood?",{"text":117,"@type":113},"MPV was significantly lower in PRP than in whole blood (p \u003C 0.001).",{"name":119,"@type":110,"acceptedAnswer":120},"Did demographic factors significantly influence MPV values?",{"text":121,"@type":113},"The results reported no significant effect of age, sex, and BMI on MPV values in either blood or PRP.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},449289,1791031785,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":44,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144,"preview_page_count":4},2336478940917,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","RESEARCH ARTICLE  \nMean Platelet Volume in Blood vs. Platelet-Rich Plasma: Demographic Analysis and Intrasubject Variability in PRP Therapy  \nLuis Garcia-Bordes, MD; Pedro Álvarez-Díaz, MD, PhD; Alfred Ferré-Aniorte, PT, MSc;  \nPatricia Laiz-Boada, BSc; Silvia Vizcaíno-Navarro, RN; Ramon Cugat-Bertomeu, MD, PhD  \nResearch performed at Instituto Cugat, Hospital Quironsalud Barcelona, Barcelona, Spain  \nReceived: 16 April 2025 Accepted: 9 July 2025  \nAbstract  \nObjectives: To evaluate inter- and intraindividual differences in mean platelet volume (MPV) between blood and platelet-rich plasma (PRP), and to assess the influence of demographic factors (sex, age,  \n2024) . MPV values in blood and PRP were compared. Intrasubject variability was analyzed in a subgroup of 298  \neffect on MPV. The coefficient of variation (CV) was low in both blood (2 .78%) and PRP (3 .87%), with the variation in PRP being significantly greater than that in blood (p \u003C 0.001) . Intrasubject MPV variability was low (coefficient of  \nappear to influence platelet size, the greater intersubject variability—compared to low intrasubject variability—suggests that centrifugation protocols play a key role in determining PRP composition. These findings support the reliability of the single-step PRP preparation method used in this study and highlight the importance of protocol  \nKeywords: Age , Body mass index (BMI) , Mean platelet volume (MPV) , Platelet-rich plasma (PRP) , Sex  \nvariation (CV): 2.78% in blood, 3.87% in PRP; p \u003C 0.001), while intersubject variability was greater in PRP.  \n standardization to ensure consistent biological quality, which may ultimately impact the therapeutic effectiveness of   \nbody mass index (BMI)) .  \npatients who received at least three PRP doses.  \nConclusion: Centrifugation significantly reduces MPV in PRP compared to whole blood, indicating that the  \nPRP in musculoskeletal treatments.  \nMethods: A retrospective analysis of 877 patients treated with PRP for musculoskeletal conditions (Nov 2021–Dec  \nResults: MPV was significantly lower in PRP compared to blood (p \u003C 0.001) . Age, sex, and BMI had no significant  \n preparation process alters platelet characteristics. While demographic factors such as age, sex, and BMI do not   \nLevel of evidence: IV  \nIntroduction  \nI n recent years, regenerative medicine has emerged  \nas a transformative field, with platelet-rich plasma  \n(PRP) garnering significant attention because of its crucial role in tissue repair and regenerative potential.1-5 This is driven primarily by the high concentration of growth factors released by platelets.6,7 However, the PRP concentration is influenced by the preparation process, particularly centrifugation protocols, which not only concentrate platelets but also impact their activation and the release of growth factors. 1,8-11 Additionally, factors such as sex, age, and body mass index (BMI) have been reported to influence PRP quality.12-15  \nWhile the literature has extensively examined the platelet  \nconcentration in PRP,11,16 few studies have focused on platelet size, particularly the mean platelet volume (MPV), in the final PRP product. The MPV, a key hematological parameter, reflects the average size of platelets and serves asan indicator of platelet function and production.17 Larger platelets are generally considered more metabolically and enzymatically active and contain higher concentrations of growth factors and proinflammatory mediators.18-20 Additionally, MPV has been linked to platelet turnover, with increased values often indicating accelerated thrombopoiesis or increased platelet activation. In contrast, a decreased MPV may suggest platelet senescence or altered production dynamics.17,21 In the context of PRP  \ntherapy, understanding MPV variations is essential, as platelet functionality influences growth factor release and, consequently, tissue regeneration potential. 1,8,9  \nInconsistent MPV values may affect PRP treatment outcomes, as efficac","cbCaikaDrByU0FMT","https://ap.wps.com/l/cbCaikaDrByU0FMT","pdf",846347,"English","# Abstract\n## Objectives\n## Methods\n## Results\n## Conclusion\n# Introduction\n## Background on regenerative medicine and PRP\n## Role of MPV in platelet function and therapy\n## Study aims and hypotheses\n# Materials and Methods\n## Study design and patient database\n## PRP treatment protocol and follow-up measurements","[{\"question\":\"What was the study designed to evaluate regarding MPV?\",\"answer\":\"The study evaluated inter- and intraindividual differences in mean platelet volume (MPV) between whole blood and platelet-rich plasma (PRP), and assessed the role of demographic factors such as sex, age, and BMI.\"},{\"question\":\"How did MPV in PRP compare with MPV in whole blood?\",\"answer\":\"MPV was significantly lower in PRP than in whole blood (p \\u003c 0.001).\"},{\"question\":\"Did demographic factors significantly influence MPV values?\",\"answer\":\"The results reported no significant effect of age, sex, and BMI on MPV values in either blood or PRP.\"}]","Mean Platelet Volume in Blood vs. Platelet-Rich Plasma: Demographic Analysis and Intrasubject Variability in PRP Therapy | PDF",1790729723,23]