[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-331825-105":59,"doc-detail-331825-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","matrix-metalloproteinases-as-biomarkers-and-therapeutic-targets-in-colitis-associated-cancer-review","Matrix Metalloproteinases as Biomarkers and Therapeutic Targets in Colitis-Associated Cancer - Review","","Colitis-associated cancer (CAC) arises on a background of chronic inflammatory bowel disease, particularly ulcerative colitis and Crohn’s disease, and colorectal cancer therapies for advanced disease remain limited. Matrix metalloproteinases (MMPs), a 24-member family of zinc- and calcium-dependent endopeptidases, drive extracellular matrix degradation required for colon tumor expansion, invasion, and metastasis. This review consolidates evidence on MMP roles in CAC development and progression and evaluates MMPs as prognostic biomarkers and as adjuvant therapeutic targets, emphasizing early-phase activity.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/matrix-metalloproteinases-as-biomarkers-and-therapeutic-targets-in-colitis-associated-cancer-review/331825/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/matrix-metalloproteinases-as-biomarkers-and-therapeutic-targets-in-colitis-associated-cancer-review/331825.png","ImageObject",300,407,{"name":92,"@type":93},"Logic","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-22","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What are matrix metalloproteinases (MMPs) and why are they important in CAC?","Question",{"text":112,"@type":113},"MMPs are zinc- and calcium-dependent endopeptidases that degrade the extracellular matrix. They support colon tumor expansion, invasion, and metastasis, making them central to CAC biology.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How does knowledge of MMPs in CAC compare with sporadic colorectal cancer?",{"text":117,"@type":113},"The document notes that, despite strong interest in sporadic colorectal cancer, relatively little attention has been paid to MMP roles in colitis-associated colon cancer.",{"name":119,"@type":110,"acceptedAnswer":120},"What is the review’s main goal regarding MMPs in CAC?",{"text":121,"@type":113},"The review aims to synthesize data on how MMPs contribute to CAC development and progression, identify prognostic and therapeutic opportunities, and propose novel research directions using MMPs as biomarkers and therapeutic targets.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},331825,1790118718,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},1099513958762,"https://ap-avatar.wpscdn.com/avatar/1000023916a998db790?x-image-process=image/resize,m_fixed,w_180,h_180&k=1784791008015729253","TYPE Review  \nPUBLISHED 15 January 2024 DOI 10.3389/fonc.2023.1325095  \nOPEN ACCESS  \nEDITED BY  \nShuyun Rao,  \nFeinstein Institute for Medical Research, United States  \nREVIEWED BY  \nMansoor-Ali Vaali-Mohammed, King Saud University, Saudi Arabia Nicolas Etique,  \nUMR7369 Matrice extracellulaire et dynamique cellulaire (MEDyC), France Hong Gu,  \nGenhawk (Wuhan) Biotech Co., Ltd., China  \n*CORRESPONDENCE Jean-Pierre Raufman  \n[jraufman@som.umaryland.edu](jraufman@som.umaryland.edu)  \n†These authors have contributed equally to this work and share first authorship  \nRECEIVED 20 October 2023  \nACCEPTED 26 December 2023  \nPUBLISHED 15 January 2024  \nCITATION  \nSampaio Moura N, Schledwitz A, Alizadeh M, Patil SA and Raufman J-P (2024)  \nMatrix metalloproteinases as biomarkers and therapeutic targets in colitis-associated cancer.  \nFront. Oncol. 13:1325095 .  \ndoi: 10.3389/fonc.2023.1325095  \nCOPYRIGHT  \n© 2024 Sampaio Moura, Schledwitz, Alizadeh, Patil and Raufman. This is an open-access article distributed under the terms of the  \nCreative Commons Attribution License (CC BY) .  \nThe use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nMatrix metalloproteinases as biomarkers and therapeutic targets in colitisassociated cancer  \nNatalia Sampaio Moura 1†, Alyssa Schledwitz 1†, Madeline Alizadeh2, Seema A. Patil 1 and Jean-Pierre Raufman 1,3,4,5*  \n1 Department of Medicine, Division of Gastroenterology and Hepatology, University of Maryland School of Medicine, Baltimore, MD, United States, 2The Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, United States, 3 Medical Service, Veterans Affairs Maryland Healthcare System, Baltimore, MD, United States, 4 Marlene and Stewart Greenebaum Cancer Center, University of Maryland Medical Center, Baltimore, MD, United States, 5 Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore,  \nMD, United States  \nColorectal cancer (CRC) remains a major cause of morbidity and mortality. Therapeutic approaches for advanced CRC are limited and rarely provide longterm benefit. Enzymes comprising the 24-member matrix metalloproteinase (MMP) family of zinc-and calcium-dependent endopeptidases are key players in extracellular matrix degradation, a requirement for colon tumor expansion, invasion, and metastasis; hence, MMPs are an important research focus . Compared to sporadic CRC, less is known regarding the molecular mechanisms and the role of MMPs in the development and progression of colitis-associated cancer (CAC) − CRC o n a background of chronic inflammatory bowel disease (IBD) − primarily ulcerative colitis and Crohn ’s disease. Hence, the potential of MMPs as biomarkers and therapeutic targets for CAC is uncertain. Our goal was to review data regarding the role of MMPs in the development and progression of CAC. We sought to identify promising prognostic and therapeutic opportunities and novel lines of investigation. A key observation is that since MMPs may be more active in early phases of CAC, using MMPs as biomarkers of advancing neoplasia and as potential therapeutic targets for adjuvant therapy in those with advanced stage primary CAC rather than overt metastases may yield more favorable outcomes.  \nKEYWORDS  \nmatrix metalloproteinases, colitis-associated cancer, colorectal cancer, inflammatory bowel disease, tissue inhibitors of metalloproteinas es, enzymes, cell invasion, biomarkers  \nFrontiers in Oncology 01 [frontiersin.org](frontiersin.org)  \n1 Introduction  \nEnzymes comprising the 24-member matrix metalloproteinase (MMP) family of zinc- and calcium-dependent endopeptidases play key roles in cancer progression by degrading the extracell","cbCaifOZrBKcB6z5","https://ap.wps.com/l/cbCaifOZrBKcB6z5","pdf",3513223,13,"English","# Introduction\n## Matrix metalloproteinases in cancer progression\n## Differential roles in sporadic CRC versus CAC\n## Rationale and review aims","[{\"question\":\"What are matrix metalloproteinases (MMPs) and why are they important in CAC?\",\"answer\":\"MMPs are zinc- and calcium-dependent endopeptidases that degrade the extracellular matrix. They support colon tumor expansion, invasion, and metastasis, making them central to CAC biology.\"},{\"question\":\"How does knowledge of MMPs in CAC compare with sporadic colorectal cancer?\",\"answer\":\"The document notes that, despite strong interest in sporadic colorectal cancer, relatively little attention has been paid to MMP roles in colitis-associated colon cancer.\"},{\"question\":\"What is the review’s main goal regarding MMPs in CAC?\",\"answer\":\"The review aims to synthesize data on how MMPs contribute to CAC development and progression, identify prognostic and therapeutic opportunities, and propose novel research directions using MMPs as biomarkers and therapeutic targets.\"}]","Matrix Metalloproteinases as Biomarkers and Therapeutic Targets in Colitis-Associated Cancer - Review | PDF",1789995360,33]