[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-461368-105":59,"doc-detail-461368-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","maternalfetal-implications-of-mpox-infection-review","Maternal–Fetal Implications of Mpox Infection - Review","","Mpox is an emerging zoonotic infection caused by the Monkeypox virus and has gained global relevance after the 2022 outbreak, shifting from sporadic zoonotic events to sustained human-to-human spread through close physical and intimate contact. Typical symptoms include fever, lymphadenopathy, and progressive mucocutaneous lesions with severity influenced by viral clade, immune status, and comorbidities. Current evidence summarizes virology, diagnosis, prevention, and management, highlighting obstetric challenges, potential vertical transmission, and perinatal risks, alongside vaccination and supportive care considerations.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/maternalfetal-implications-of-mpox-infection-review/461368/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/maternalfetal-implications-of-mpox-infection-review/461368.png","ImageObject",300,407,{"name":92,"@type":93},"Ben ","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-06","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What causes mpox and how does it spread to humans?","Question",{"text":113,"@type":114},"Mpox is caused by the Monkeypox virus (an Orthopoxvirus). It spreads through contact with infected individuals and contaminated materials, including lesion-derived materials and respiratory droplets.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"Which mpox variant patterns are linked to disease severity?",{"text":118,"@type":114},"The 2022 outbreak was predominantly associated with the Clade IIb variant, described as milder with more localized lesions and reduced mortality compared with the more virulent Clade I.",{"name":120,"@type":111,"acceptedAnswer":121},"How is mpox diagnosed and what treatments are considered during severe disease?",{"text":122,"@type":114},"Diagnosis relies primarily on polymerase chain reaction testing from lesion-derived samples. Management is largely supportive, while antivirals such as tecovirimat may be considered for severe cases or high-risk populations; other antivirals are described as contraindicated in pregnancy contexts.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},461368,1790789633,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146,"preview_page_count":4},2336478951081,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","Review  \nMaternal–Fetal Implications of Mpox Infection: Current Evidence  \nStefany Silva Pereira 1, Antonio Braga 2,3,4, Beatriz Bussi Rosolen 1, Talita Almeida Durães 1, Marcela Fermoselle de Vita Silva 1, Giovanna Alves de Britto 1, Giuliana Augustinelli Sales 1,  \nGustavo Yano Callado 5, Camilla Martins dos Santos Maia 6, Evelyn Traina 6, Edward Araujo Júnior 1,6, Gabriele Tonni 7 and Roberta Granese 8, *  \nAcademic Editor: Catalina de Paco-Matallana  \nReceived: 22 November 2025  \nRevised: 25 December 2025  \nAccepted: 1 January 2026  \nPublished: 5 January 2026  \nCorrection Statement: This article has been republished with a minor change. The change does not affect the scientific content of the article and further details are available within the backmatter of the website version of this article.  \nCopyright: © 2026 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.  \n1 Discipline of Woman Health, Municipal University of São Caetano do Sul (USCS), São Caetano do Sul 09521-160, SP, Brazil; [stefany.pereira@uscsonline.com.br](stefany.pereira@uscsonline.com.br) (S.S.P.); [beatriz.rosolen@uscsonline.com.br](beatriz.rosolen@uscsonline.com.br) (B.B.R.); [talita.duraes@uscsonline.com.br](talita.duraes@uscsonline.com.br) (T.A.D.); [marcela.silva1@uscsonline.com.br](marcela.silva1@uscsonline.com.br) (M.F.d.V.S.); [giovanna.britto@uscsonline.com.br](giovanna.britto@uscsonline.com.br) (G.A.d.B.); [giuliana.sales@uscsonline.com.br](giuliana.sales@uscsonline.com.br) (G.A.S.); [araujojred@terra.com.br](araujojred@terra.com.br) (E.A.J.)  \n2 Department of Gynecology and Obstetrics, School of Medicine, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 22240-003, RJ, Brazil; [bragamed@yahoo.com.br](bragamed@yahoo.com.br)  \n3 Department of Maternal and Child Health, School of Medicine, Fluminense Federal University (UFF), Niterói 24070-090, RJ, Brazil  \n4 Postgraduate Program in Applied Health Sciences, University of Vassouras, Vassouras 27700-000, RJ, Brazil  \n5 Albert Einstein Israelite College of Health Sciences (FICSAE), Albert Einstein Israelite Hospital, São Paulo 05652-900, SP, Brazil; [gycallado@gmail.com](gycallado@gmail.com)  \n6 Department of Obstetrics, Paulista School of Medicine, Federal University of São Paulo (EPM-UNIFESP),  \nSão Paulo 04023-062, SP, Brazil; [camilla.maia@unifesp.br](camilla.maia@unifesp.br) (C.M.d.S.M.); [etraina@unifesp.br](etraina@unifesp.br) (E.T.)  \n7 Department of Obstetrics and Neonatology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), AUSL Reggio Emilia, 42123 Reggio Emilia, Italy; [gabriele.tonni@ausl.re.it](gabriele.tonni@ausl.re.it)  \n8 Department of Biomedical and Dental Sciences and Morphofunctional Imaging,“G. Martino” University Hospital, 98100 Messina, Italy  \n* Correspondence: [robertagr74@gmail.com](robertagr74@gmail.com)  \nAbstract  \nMpox is an emerging zoonotic infection caused by the Monkeypox virus, an Orthopoxvirus with increasing global relevance following the 2022 multinational outbreak. Historically endemic to Central and West Africa, the disease has evolved from sporadic zoonotic transmission to sustained human-to-human spread, particularly through close physical and intimate contact. Clinical manifestations typically include fever, lymphadenopathy, and progressive mucocutaneous lesions, although severity varies according to viral clade, immune status, and comorbidities. The 2022 outbreak, predominantly associated with the Clade IIb variant, was characterized by milder disease, localized lesions, and reduced mortality compared with the more virulent Clade I variant. Despite this, severe outcomes remain possible, particularly in vulnerable groups such as children, pregnant individuals, immunocompromised patients, and persons with extensive dermatological disorders. Diagnosis relies primarily on polymerase chain reaction testing f","cbCaig0lZmTFJAPv","https://ap.wps.com/l/cbCaig0lZmTFJAPv","pdf",1244060,17,"English","# Introduction\n## Abstract\n## Keywords\n# Mpox infection overview\n## Zoonotic origin and transmission\n# Obstetric considerations\n## Vertical transmission risk\n## Perinatal outcomes\n# Diagnosis and management\n## PCR-based diagnosis\n## Supportive care and antivirals\n# Prevention\n## Vaccination strategies","[{\"question\":\"What causes mpox and how does it spread to humans?\",\"answer\":\"Mpox is caused by the Monkeypox virus (an Orthopoxvirus). It spreads through contact with infected individuals and contaminated materials, including lesion-derived materials and respiratory droplets.\"},{\"question\":\"Which mpox variant patterns are linked to disease severity?\",\"answer\":\"The 2022 outbreak was predominantly associated with the Clade IIb variant, described as milder with more localized lesions and reduced mortality compared with the more virulent Clade I.\"},{\"question\":\"How is mpox diagnosed and what treatments are considered during severe disease?\",\"answer\":\"Diagnosis relies primarily on polymerase chain reaction testing from lesion-derived samples. Management is largely supportive, while antivirals such as tecovirimat may be considered for severe cases or high-risk populations; other antivirals are described as contraindicated in pregnancy contexts.\"}]","Maternal–Fetal Implications of Mpox Infection - Review | PDF",1790761441,43]