[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-377960-105":59,"doc-detail-377960-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","maternal-migraine-and-risk-of-pediatric-cancers","Maternal migraine and risk of pediatric cancers","","Maternal migraine has been linked to adverse birth outcomes and congenital anomalies, and adult migraine shows differing cancer incidence patterns. Using Danish national registry data, the study evaluates whether maternal diagnoses of migraine relate to cancer risk in offspring. Children under 20 were identified from the Cancer Registry, with controls from the Central Population Register matched by birth year and sex. Migraine diagnoses and related acute or prophylactic treatments were captured from patient and pharmaceutical registers, then logistic regression estimated childhood cancer risks.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/maternal-migraine-and-risk-of-pediatric-cancers/377960/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/maternal-migraine-and-risk-of-pediatric-cancers/377960.png","ImageObject",300,407,{"name":92,"@type":93},"Jake","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-24","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What data source was used to study maternal migraine and childhood cancer risk?","Question",{"text":113,"@type":114},"The study used Danish national registries. Childhood cancer cases came from the Cancer Registry and controls from the Central Population Register, with migraine diagnoses identified from the National Patient Register and treatments captured from the National Pharmaceutical Register.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How were migraine exposures defined for the mothers?",{"text":118,"@type":114},"Migraine diagnoses were identified using ICD-8 and ICD-10 codes in the National Patient Register, and migraine-specific acute or prophylactic treatment was recorded in the National Pharmaceutical Register.",{"name":120,"@type":111,"acceptedAnswer":121},"Which childhood cancers showed positive associations with maternal migraine?",{"text":122,"@type":114},"Maternal migraine was positively associated with non-Hodgkin lymphoma, central nervous system tumors (including glioma), neuroblastoma, and osteosarcoma.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},377960,1790553075,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146},962084928904,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","Author Manuscript Author Manuscript Author Manuscript Author Manuscript  \n\n| | HHS Public Access\u003Cbr>Author manuscript\u003Cbr>Pediatr Blood Cancer. Author manuscript; available in PMC 2023 July 01. |\n| --- | --- |\n\nPublished in final edited form as:  \nPediatr Blood Cancer. 2023 July ; 70(7): e30385 . doi:10.1002/pbc.30385 .  \nMaternal migraine and risk of pediatric cancers  \nHelen T. Orimoloye 1 , Julia E. Heck 1,2 , Andrew Charles3 , Chai Saechao4 , Di He2 , Noah Federman5 , Jorn Olsen6 , Beate Ritz2 , Johnni Hansen7  \n1College of Health and Public Service, University of North Texas, Denton, Texas, USA  \n2 Department of Epidemiology, Fielding School of Public Health, Los Angeles, California, USA  \n3Goldberg Migraine Program, Department of Neurology, UCLA Geffen School of Medicine, Los Angeles, California, USA  \n4 UCLA Health, University of California, Los Angeles, California, USA  \n5 Department of Pediatrics, David Geffen School of Medicine, University of California, Los Angeles, California, USA  \n6 Department of Clinical Epidemiology, Aarhus University, Aarhus, Denmark  \n7 Danish Cancer Society Research Center, Copenhagen, Denmark  \nAbstract  \nBackground: Maternal migraine has been linked to adverse birth outcomes including low birth weight and preterm birth, as well as congenital anomalies in offspring. It has been speculated that this may be due to the use of medications in pregnancy, but lifestyle, genetic, hormonal, and neurochemical factors could also play a role. There is evidence for varying cancer incidences among adults with migraine. Here, we utilized data from national registries in Denmark to examine associations between maternal diagnoses of migraine and risk for cancer in offspring.  \nMethods: We linked several national registries in Denmark to identify cases from the Cancer Registry among children less than 20 years (diagnoses 1996–2016) and controls from the Central Population Register, matched to cases by birth year and sex (25:1 matching rate) . Migraine diagnoses were identified from the National Patient Register using International Classification of Diseases, versions 8 and 10 codes and migraine-specific acute or prophylactic treatment recorded in the National Pharmaceutical Register. We used logistic regression to estimate the risk of childhood cancers associated with maternal migraine.  \nThis is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.  \nCorrespondence: Julia E. Heck, College of Health and Public Service, UNT, 1155 Union Circle \\#311340, Denton, TX 76203-5017, [USA. julia.heck@unt.edu](USA. julia.heck@unt.edu).  \nHelen T. Orimoloye and Julia E. Heck are the co-first authors for this work.  \nCONFLICT OF INTEREST STATEMENT Authors report no conflicts of interest.  \nSUPPORTING INFORMATION  \nAdditional supporting information can be found online in the Supporting Information section at the end of this article.  \nAuthor Manuscript Author Manuscript Author Manuscript Author Manuscript  \nOrimoloye et al. Page 2  \nResults: Maternal migraine was positively associated with risk for non-Hodgkin lymphoma (odds ratio [OR] = 1.70, 95% confidence interval [CI]: 1.01–2.86), central nervous system tumors ([OR = 1.31, 95% CI: 1.02–1.68], particularly glioma [OR = 1.64, 95% CI: 1.12–2.40]), neuroblastoma (OR = 1.75, 95% CI: 1.00–3.08), and osteosarcoma (OR = 2.60, 95% CI: 1.18– 5.76) .  \nConclusions: Associations with maternal migraine were observed for several childhood cancers, including neuronal tumors. Our findings raise questions about the role of lifestyle factors, sex hormones, genetic, and neurochemical factors in the relationship between migraine and childhood cancers.  \nKeywords  \ncentral nervous system tumors; childhood cancer; estrogen; germ cell tumors; migraine; nonHodgkin lymphoma; o","cbCaipdolMxr5Hib","https://ap.wps.com/l/cbCaipdolMxr5Hib","pdf",100339,14,"English","# Abstract\n## Background\n## Methods\n## Results\n## Conclusions\n# Introduction\n## Migraine prevalence and hormonal influences\n## Comorbidities and pregnancy outcomes\n## Links to childhood cancer risk","[{\"question\":\"What data source was used to study maternal migraine and childhood cancer risk?\",\"answer\":\"The study used Danish national registries. Childhood cancer cases came from the Cancer Registry and controls from the Central Population Register, with migraine diagnoses identified from the National Patient Register and treatments captured from the National Pharmaceutical Register.\"},{\"question\":\"How were migraine exposures defined for the mothers?\",\"answer\":\"Migraine diagnoses were identified using ICD-8 and ICD-10 codes in the National Patient Register, and migraine-specific acute or prophylactic treatment was recorded in the National Pharmaceutical Register.\"},{\"question\":\"Which childhood cancers showed positive associations with maternal migraine?\",\"answer\":\"Maternal migraine was positively associated with non-Hodgkin lymphoma, central nervous system tumors (including glioma), neuroblastoma, and osteosarcoma.\"}]","Maternal migraine and risk of pediatric cancers | PDF",1790227813,35]