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This review describes how microfluidic platforms exploit sub-microliter sample volumes and microscale fluid dynamics to advance sensing and diagnostics. Sensor-based and point-of-care microfluidics improve biomarker detection from saliva, urine, blood, and serum, while tumor-on-a-chip models enable patient-specific, high-throughput drug screening and personalized therapy development, concluding with obstacles to clinical translation.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/mapping-the-potential-of-microfluidics-in-early-diagnosis-and-personalized-treatment-of-head-and-neck-cancers-review/377100/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/mapping-the-potential-of-microfluidics-in-early-diagnosis-and-personalized-treatment-of-head-and-neck-cancers-review/377100.png","ImageObject",300,407,{"name":92,"@type":93},"นรินทร์","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",12,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"Why is early diagnosis of head and neck cancers challenging?","Question",{"text":113,"@type":114},"The head and neck region has highly perfused and innervated structures with substantial anatomical complexity, making early diagnosis and treatment difficult.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How do microfluidic devices support personalized treatment for head and neck cancers?",{"text":118,"@type":114},"Tumor-on-a-chip platforms enable patient-specific cancer models, allowing high-throughput screening of drugs to guide personalized therapy development.",{"name":120,"@type":111,"acceptedAnswer":121},"What kinds of biological specimens are used in microfluidic biosensing?",{"text":122,"@type":114},"Sensor-based microfluidics and point-of-care devices use biological specimens such as saliva, urine, blood, and serum to detect and monitor cancer biomarkers.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},377100,1790933901,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146},2336475104957,"https://ap-avatar.wpscdn.com/avatar/22000c4c6bd8a5076e1?x-image-process=image/resize,m_fixed,w_180,h_180&k=1787554080175789136","cancers   \nReview  \nMapping the Potential of Microfluidics in Early Diagnosis and Personalized Treatment of Head and Neck Cancers  \nSangeeth Pillai , Jan C. Kwan, Fares Yaziji, Hanwen Yu and Simon D. Tran *  \nCitation: Pillai, S.; Kwan, J.C.; Yaziji, F.; Yu, H.; Tran, S.D. Mapping the Potential of Microfluidics in Early Diagnosis and Personalized Treatment of Head and Neck Cancers. Cancers 2023, 15, 3894. [https://](https://)[ ](https://)[doi.org/10.3390/cancers15153894](doi.org/10.3390/cancers15153894)  \nAcademic Editor: Juan P. Rodrigo  \nReceived: 29 June 2023  \nRevised: 24 July 2023  \nAccepted: 27 July 2023  \nPublished: 31 July 2023  \nCopyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \nMcGill Craniofacial Tissue Engineering and Stem Cell Laboratory, Faculty of Dental Medicine and Oral Health Sciences, McGill University, Montreal, QC H3A 0C7, Canada; [sangeeth.pillai@mail.mcgill.ca](sangeeth.pillai@mail.mcgill.ca) (S.P.);  \n[jan.kwan@mail.mcgill.ca](jan.kwan@mail.mcgill.ca) (J.C.K.); [fares.yaziji@mail.mcgill.ca](fares.yaziji@mail.mcgill.ca) (F.Y.); [han.w.yu@mail.mcgill.ca](han.w.yu@mail.mcgill.ca) (H.Y.)  \n* Correspondence: [simon.tran@mcgill.ca](simon.tran@mcgill.ca)  \nSimple Summary: Head and neck cancers (HNCs) are a group of cancers that affect parts like the mouth, throat, and glands in the neck. These cancers are quite complex and can be challenging to detect and treat early. Microfluidic devices are miniature chips that use a small volume of biological samples and have helped in understanding these cancers better. They have revolutionized the way we diagnose and treat cancer. These devices have also allowed us to create models of individual patients' cancers on a chip, which help develop personalized treatments. In this review, we will talk about how microfluidics has improved the screening of drugs for treating HNC and how it helps in detecting cancer early and in understanding how treatments work. We will also discuss the challenges we face in using these microfluidic technologies in real-life medical settings.  \nAbstract: Head and neck cancers (HNCs) account for ~4% of all cancers in North America and encompass cancers affecting the oral cavity, pharynx, larynx, sinuses, nasal cavity, and salivary glands. The anatomical complexity of the head and neck region, characterized by highly perfused and innervated structures, presents challenges in the early diagnosis and treatment of these cancers. The utilization of sub-microliter volumes and the unique phenomenon associated with microscale fluid dynamics have facilitated the development of microfluidic platforms for studying complex biological systems. The advent of on-chip microfluidics has significantly impacted the diagnosis and treatment strategies of HNC. Sensor-based microfluidics and point-of-care devices have improved the detection and monitoring of cancer biomarkers using biological specimens like saliva, urine, blood, and serum. Additionally, tumor-on-a-chip platforms have allowed the creation of patientspecific cancer models on a chip, enabling the development of personalized treatments through high-throughput screening of drugs. In this review, we first focus on how microfluidics enable the development of an enhanced, functional drug screening process for targeted treatment in HNCs. We then discuss current advances in microfluidic platforms for biomarker sensing and early detection, followed by on-chip modeling of HNC to evaluate treatment response. Finally, we address the practical challenges that hinder the clinical translation of these microfluidic advances.  \nKeywords: head and neck cancers; microfluidics; personalized medicine; biosensing; tumor-on-chip; high throu","cbCaifAOFqhJbN8H","https://ap.wps.com/l/cbCaifAOFqhJbN8H","pdf",1526062,23,"English","# Introduction\n## Microfluidics for drug screening and targeted treatment\n## Microfluidic platforms for biomarker sensing and early detection\n## On-chip modeling for evaluating treatment response\n## Challenges for clinical translation","[{\"question\":\"Why is early diagnosis of head and neck cancers challenging?\",\"answer\":\"The head and neck region has highly perfused and innervated structures with substantial anatomical complexity, making early diagnosis and treatment difficult.\"},{\"question\":\"How do microfluidic devices support personalized treatment for head and neck cancers?\",\"answer\":\"Tumor-on-a-chip platforms enable patient-specific cancer models, allowing high-throughput screening of drugs to guide personalized therapy development.\"},{\"question\":\"What kinds of biological specimens are used in microfluidic biosensing?\",\"answer\":\"Sensor-based microfluidics and point-of-care devices use biological specimens such as saliva, urine, blood, and serum to detect and monitor cancer biomarkers.\"}]","Mapping the Potential of Microfluidics in Early Diagnosis and Personalized Treatment of Head and Neck Cancers - Review | PDF",1790223186,58]