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Records were retrieved from the Web of Science Core Collection and analyzed with Origin 2018, R, VOSviewer, and CiteSpace to build cooperation, co-citation, and keyword networks. Results identify 897 papers, with peaks in 2023, China leading output, key hotspots in circulating tumor cell isolation and exosome-focused analysis, and a shift toward precise applications.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/mapping-the-evolution-and-impact-of-microfluidic-technology-research-on-cancer-diagnosis-a-comprehensive-bibliometric-analysis-from-2015-to-2024/353311/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/mapping-the-evolution-and-impact-of-microfluidic-technology-research-on-cancer-diagnosis-a-comprehensive-bibliometric-analysis-from-2015-to-2024/353311.png","ImageObject",300,407,{"name":92,"@type":93},"kopisore","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-25","2026-09-22",true,{"@type":102,"interactionType":103,"userInteractionCount":19},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Which databases and tools were used to conduct the bibliometric analysis?","Question",{"text":112,"@type":113},"Relevant literature was retrieved from the Web of Science Core Collection. Analysis and visualization used Origin 2018, R software, VOSviewer, and CiteSpace.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How many studies were included, and what publication trend was observed?",{"text":117,"@type":113},"A total of 897 literatures were included. Publication counts increased, then decreased, and increased again, reaching a peak in 2023.",{"name":119,"@type":110,"acceptedAnswer":120},"What were the main research hotspots in microfluidic technology for cancer diagnosis?",{"text":121,"@type":113},"Hotspots focused on isolation and detection of circulating tumor cells, emphasizing breast, colorectal, and lung cancers, and on microfluidic analysis of exosomes.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},353311,1790125672,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":19,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":52,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},962090880963,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","®  \n Bibliometric Review   \nMapping the evolution and impact of microfluidic technology research on cancer diagnosis A comprehensive bibliometric analysis from 2015 to 2024  \nXinxiang Su, MDa , Junjun Pu, MDa , Jinxia Liao, MDa , Jilin Li, MDa , Juanjuan Huang, MDa , Zhen Wu, PhDb ,*  \n\n| Abstract\u003Cbr>Background: To explore the research trends of microfluidic technology for cancer diagnosis from 2015 to 2024 using bibliometric and visualization methods (not a Preferred Reporting Items for Systematic Reviews and Meta-Analyses-compliant systematic review), and provide references for subsequent scientific research.\u003Cbr>Methods: Relevant literatures were retrieved from the Web of Science Core Collection, and analyzed using tools such as Origin 2018, R software, VOSviewer, and CiteSpace. The cooperation network, co -citation network, and keyword co -occurrence network was constructed.\u003Cbr>Results: A total of 897 literatures were included. The number of literatures first increased, then decreased, and then increased again, reaching a peak in 2023. China had the highest literature output (358 articles), but the international co-authorship rate was low (19%) . Biosensors & Bioelectronics had high publication and citation numbers. The research hotspots were the isolation and detection of circulating tumor cells (with a focus on breast cancer, colorectal cancer, and lung cancer, accounting for 36%) and microfluidic analysis of exosomes (accounting for 24%) . Keyword clustering involved microfluidic device materials, tumor cell detection, exosome applications, and cancer mechanism research. The research direction shifted from broad-based technology to precise applications for specific cancers and samples.\u003Cbr>Conclusion: This study clarified the research status and hotspots in this field. Microfluidic technology contributes to the early and accurate diagnosis of cancer. In the future, international cooperation should be strengthened to explore more potential of microfluidic technology in cancer diagnosis and improve the level of early diagnosis.\u003Cbr>Abbreviations: CTC s = circulating tumor cells, EVs = extracellular vesicles, IF = impact factor, NIH = National Institutes of Health, NSFC = National Natural Science Foundation of China, PRISMA = Preferred Reporting Items for Systematic Reviews and Meta-Analyses, UAE = United Arab Emirates, US = United States, WOSCC = Web of Science Core Collection. |\n| --- |\n| Keywords: bibliometrics, cancer diagnosis, microfluidic technology, visual analysis |\n\n1. Introduction  \nCancer poses a serious threat to human life and health. [1] Early and accurate diagnosis is the key to improving patients’ survival rate and prognosis.[2] Taking colorectal cancer as an example, if it is detected and treated in the early stage, the 5-year survival rate can reach over 90%, while when it is detected in the advanced stage, the survival rate may be \u003C10% . [3] However, traditional cancer diagnosis methods have many limitations. Tissue biopsy is an invasive procedure that can cause pain to patients and may also trigger complications such as infection and bleeding. [4,5] Moreover, the obtained samples are limited,  \nThis work was supported by the University Innovation and Entrepreneurship Training Program in China (grant nos. S202310601098 and 202410601001S). The authors have no conflict of interest to disclose.  \nThe datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.  \nSupplemental Digital Content is available in the online version of this article ([http://](http://)[ ](http://)[dx.doi.org/10.1097/MD.0000000000049910](dx.doi.org/10.1097/MD.0000000000049910)).  \na Guilin Medical University, Guilin, Guangxi, China, b Faculty of Basic Medical Science, Guilin Medical University, Guilin, Guangxi, China.  \n* Correspondence: Zhen Wu, Faculty of Basic Medical Science, Guilin Medical University, Guilin, Guangxi, China ([e-mail: wuzhen@glmc.edu.cn](e-mai","cbCaincupphicni7","https://ap.wps.com/l/cbCaincupphicni7","pdf",8317081,"English","# Introduction\n# Methods\n# Results\n# Conclusion\n# Abbreviations\n# Keywords","[{\"question\":\"Which databases and tools were used to conduct the bibliometric analysis?\",\"answer\":\"Relevant literature was retrieved from the Web of Science Core Collection. Analysis and visualization used Origin 2018, R software, VOSviewer, and CiteSpace.\"},{\"question\":\"How many studies were included, and what publication trend was observed?\",\"answer\":\"A total of 897 literatures were included. Publication counts increased, then decreased, and increased again, reaching a peak in 2023.\"},{\"question\":\"What were the main research hotspots in microfluidic technology for cancer diagnosis?\",\"answer\":\"Hotspots focused on isolation and detection of circulating tumor cells, emphasizing breast, colorectal, and lung cancers, and on microfluidic analysis of exosomes.\"}]","Mapping the evolution and impact of microfluidic technology research on cancer diagnosis - A comprehensive bibliometric analysis from 2015 to 2024 | PDF",1790104653,25]