[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-332674-105":59,"doc-detail-332674-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","mangiferin-an-effective-agent-against-human-malignancies","Mangiferin: An effective agent against human malignancies","","Mangiferin is a mango-derived bioactive polyphenol present at high concentration that has attracted significant interest for cancer prevention and therapy. It can act against rectal, prostate, ovarian, leukemia, gastric, liver, lung cancers and chronic pancreatitis by modulating multiple signaling pathways including STAT3, Smac/DIABLO, NF-κB, PI3K/Akt, and TGF-β/SMAD, among others. By triggering apoptosis and stopping cell-cycle progression, it may also inhibit proliferation and metastasis. Targets include adhesion molecules, cytokines, pro-inflammatory transcription factors, kinases, chemokines, growth factors, and cell-cycle proteins, with evidence across lung, cervical, breast, brain, and prostate cancers as well as leukemia, alone or combined with anticancer agents. Further clinical trials are needed to fully realize its potential.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/mangiferin-an-effective-agent-against-human-malignancies/332674/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/mangiferin-an-effective-agent-against-human-malignancies/332674.png","ImageObject",300,407,{"name":92,"@type":93},"Sage","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-27","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",12,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What is mangiferin and where is it found?","Question",{"text":113,"@type":114},"Mangiferin is a bioactive polyphenol found in mangoes at high concentration and also present in some other fruits.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How does mangiferin exert anticancer effects?",{"text":118,"@type":114},"Mangiferin modulates multiple key signaling pathways, triggers apoptotic signals, and halts cell-cycle advancement, which can prevent cancer cell proliferation and development.",{"name":120,"@type":111,"acceptedAnswer":121},"Which cancers are discussed as having potential benefits from mangiferin?",{"text":122,"@type":114},"The abstract highlights potential benefits in lung, cervical, breast, brain, and prostate cancers, as well as leukemia, when administered alone or combined with recognized anticancer compounds.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},332674,1790106468,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146},687197207057,"https://ap-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0","Received: 21 May 2024 | Revised: 9 August 2024 | Accepted: 13 August 2024  \nDOI: 10. 1002/fsn3 .4434  \nRE V I E W  \nMangiferin: An effective agent against human malignancies  \nNimra Irshad1 | Hammad Naeem1,2 | Muhammad Shahbaz1 | Muhammad Imran3 | Ahmed Mujtaba4 | Muzzamal Hussain5  | Waleed Al Abdulmonem6 |  \nSuliman A. Alsagaby7 | Tadesse Fenta Yehuala8  | Mohamed A. Abdelgawad9 | Mohammed M. Ghoneim10 | Ehab M. Mostafa11,12 | Samy Selim13  | Soad K. Al Jaouni14  \n1Department of Food Science and Technology, Muhammad Nawaz Shareef University of Agriculture, Multan, Multan, Pakistan 2Post-Harvest Research Centre, Ayub Agricultural Research Institute, Faisalabad, Faisalabad, Pakistan  \n3 Department of Food Science and Technology, University of Narowal, Narowal, Pakistan  \n4Department of Food Sciences and Technology, Faculty of Engineering Sciences and Technology, Hamdard University Islamabad Campus, Islamabad, Pakistan 5Department of Food Sciences, Government College University Faisalabad, Faisalabad, Pakistan  \n6Department of Pathology, College of Medicine, Qassim University, Buraidah, Saudi Arabia  \n7Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Majmaah University, AL-Majmaah, Saudi Arabia 8 Faculty of Chemical and Food Engineering, Bahir Dar Institute of Technology, Bahir Dar University, Bahir dar, Ethiopia  \n9Department of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Sakaka, Aljouf, Saudi Arabia 10 Department of Pharmacy Practice, College of Pharmacy, AlMaarefa University, Ad Diriyah, Riyadh, Saudi Arabia 11Department of Pharmacognosy, College of Pharmacy, Jouf University, Sakaka, Saudi Arabia  \n12Pharmacognosy and Medicinal Plants Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt 13 Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Sakaka, Saudi Arabia  \n14Department of Hematology/Oncology, Yousef Abdulatif Jameel Scientific Chair of Prophetic Medicine Application, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia  \nCorrespondence  \nTadesse Fenta Yehuala, Faculty of Chemical and Food Engineering, Bahir Dar Institute of Technology, Bahir Dar University, Bahir dar, Ethiopia.  \nEmail: [tadeyfenta@gmail.com](tadeyfenta@gmail.com)  \n[Soad K. Al Jaouni](Soad K. Al Jaouni), Department of Hematology/Oncology, Yousef Abdulatif Jameel Scientific Chair of Prophetic Medicine Application, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia.  \nEmail: [saljaouni@kau.edu.sa](saljaouni@kau.edu.sa)  \nAbstract  \nMangiferin is a bioactive substance present in high concentration in mangoes and also in some other fruits. Owing to its potential as a chemopreventive and chemotherapeutic agent against several types of cancer, this unique, significant, and well-researched polyphenol has received a lot of attention recently. It possesses the ability to treat cancers, including rectal cancer, prostate cancer, ovarian cancer, leukemia, gastric cancer, liver cancer, chronic pancreatitis, and lung cancer. It can control/regulate multiple key signaling pathways, such as signal transducer and activator of transcription 3 (STAT3), second mitochondria-derived activator of caspases/direct inhibitor of apoptosis (IAP) -binding protein with low propidium iodide (pl) (Smac/DIABLO) nuclear factor kappa B (NF-κ B), phosphatidylinositol 3 kinase/protein 3 kinase (PI3K/Akt), transforming growth factor beta/suppressor of mothers against decapentaplegic (TGF-β/SMAD), c-jun N-terminal kinase/p38 mitogen-activated protein kinase (JNK/p38-MAPK), and phosphor-I kappa B kinase (p-IκB), which are crucial to the development of cancers. By triggering apoptotic signals and halting the advancement of the cell cycle, it can also  \nThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is ","cbCaiqUNHObFUKgn","https://ap.wps.com/l/cbCaiqUNHObFUKgn","pdf",1954000,21,"English","# Abstract\n# Keywords\n# Introduction","[{\"question\":\"What is mangiferin and where is it found?\",\"answer\":\"Mangiferin is a bioactive polyphenol found in mangoes at high concentration and also present in some other fruits.\"},{\"question\":\"How does mangiferin exert anticancer effects?\",\"answer\":\"Mangiferin modulates multiple key signaling pathways, triggers apoptotic signals, and halts cell-cycle advancement, which can prevent cancer cell proliferation and development.\"},{\"question\":\"Which cancers are discussed as having potential benefits from mangiferin?\",\"answer\":\"The abstract highlights potential benefits in lung, cervical, breast, brain, and prostate cancers, as well as leukemia, when administered alone or combined with recognized anticancer compounds.\"}]","Mangiferin: An effective agent against human malignancies | PDF",1789999039,53]