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A biomimetic manganese-mineralized ferritin nanoplatform loaded with dihydroartemisinin (DHA@MFn) was developed to enable stimuli-responsive, tumor microenvironment–mediated release. The system catalyzes Fenton-like reactions for Mn2+-driven hydroxyl radical production and induces ferroptosis via lipid peroxidation and GSH depletion, enhancing multimodal ovarian cancer therapy.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/manganese-biomineralized-ferritin-nanoplatforms-with-shielding-and-stimuli-responsive-release-for-potentiated-ferroptosis-and-multimodal-ovarian-cancer-therapy/352670/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/manganese-biomineralized-ferritin-nanoplatforms-with-shielding-and-stimuli-responsive-release-for-potentiated-ferroptosis-and-multimodal-ovarian-cancer-therapy/352670.png","ImageObject",300,407,{"name":92,"@type":93},"Kyle","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-23","2026-09-22",true,{"@type":102,"interactionType":103,"userInteractionCount":14},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What problem does the study aim to solve with ferritin-based delivery?","Question",{"text":112,"@type":113},"Ferritin accumulates nonspecifically in iron-metabolizing organs, which reduces targeting accuracy and therapeutic effectiveness for ovarian cancer treatment.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How was the DHA@MFn nanoplatform constructed and evaluated?",{"text":117,"@type":113},"A manganese-mineralized ferritin nanocage was used to encapsulate dihydroartemisinin, forming DHA@MFn, whose physicochemical properties and stimuliresponsiveness and in vitro release were assessed under weakly acidic conditions.",{"name":119,"@type":110,"acceptedAnswer":120},"What mechanisms drive the antitumor effect of DHA@MFn?",{"text":121,"@type":113},"Mn2+ released by DHA@MFn catalyzes Fenton-like reactions for hydroxyl radical production, while DHA triggers ferroptosis through lipid peroxidation and GSH depletion, and irradiation further enables synergistic multimodal therapy.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},352670,1790167400,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":14,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":56,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},3985741905716,"https://ap-avatar.wpscdn.com/davatar_994ba38a5ba835b3df7d355c54d3ed8d","International Journal of Nanomedicine  \n Open Access Full Text Article  \nORIGINAL RESEARCH  \nManganese Biomineralized Ferritin Nanoplatforms with Shielding and Stimuli-Responsive Release for Potentiated Ferroptosis and Multimodal Ovarian Cancer Therapy  \nDezhao Chen 1–3 , *, Xiaohan Zheng2 , 3 , *, Qiao Gao 3 ,4 , *, Bing Chen 3 , 5 , Yang Sun 1 , 3  \n1Department of Gynecology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, Fujian Province, People’s Republic of China; 2Department of Obstetrics & Gynecology, Fujian Medical University Union Hospital, Fuzhou, Fujian Province, People’s Republic of China; 3Key Laboratory of Nanomedical Technology (Education Department of Fujian Province), Department of Pharmaceutical Analysis, School of Pharmacy, Fujian Medical University, Fuzhou, Fujian Province, People’s Republic of China; 4Department of Obstetrics & Gynecology, Fujian Maternity and Child Health Hospital, Fuzhou, Fujian Province, People’s Republic of China; 5School of Medical Imaging, Fujian Medical University, Fuzhou, Fujian Province, People’s Republic of China  \n*These authors contributed equally to this work  \nCorrespondence: Yang Sun, Department of Gynecology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, Fujian Province, People’s Republic of China, Email [sunyang@fjmu.edu.cn](sunyang@fjmu.edu.cn); Bing Chen, Key Laboratory of Nanomedical Technology (Education Department of Fujian Province), Department of Pharmaceutical Analysis, School of Pharmacy, Fujian Medical University, Fuzhou, Fujian Province, People’s Republic of China, Email [BingChen_001@126.com](BingChen_001@126.com); [BingChen_001@fjmu.edu.cn](BingChen_001@fjmu.edu.cn)  \nPurpose: Natural ferritin Fn) is a cage-like protein with a central cavity, making it a promising vehicle for drug delivery. However, its non-specific accumulation in iron-metabolizing organs impairs targeting precision and therapeutic efficacy. To overcome this challenge, we aimed to develop a novel biomimetic nanoplatform based on manganese-mineralized ferritin loaded with dihydroartemisinin (DHA@MFn) for precise ovarian cancer treatment, enabling controlled drug release and amplified therapeutic effects within the tumor microenvironment.  \nMethods: We constructed a manganese-mineralized ferritin nanocage encapsulating DHA, resulting in DHA@MFn with favorable physicochemical properties, including a particle size of 12.2 nm and a zeta potential of −13.54 mV. The stability, stimuliresponsiveness, and in vitro release behavior of DHA@MFn were evaluated under weakly acidic conditions. We assessed its ability to catalyze Fenton-like reactions releasing Mn2+, induce ferroptosis via lipid peroxidation and GSH depletion, and enable controlled drug release. In vivo biodistribution, tumor accumulation, and therapeutic efficacy were investigated using SKOV3 tumor-bearing mice, alone and in combination with irradiation.  \nResults: DHA@MFn remained stable and demonstrated excellent responsiveness to the tumor microenvironment, releasing Mn2+ ions that catalyzed Fenton-like reactions for hydroxyl radical production. The nanoplatform facilitated targeted tumor accumulation and retention, significantly reducing off-target organ distribution, particularly in the liver. The release of DHA induced ferroptosis through lipid peroxidation and GSH depletion, enhancing oxidative stress. Combined with irradiation, DHA@MFn achieved superior tumor ablation through synergistic ferroptosis, photothermal effects, and minimal systemic toxicity compared to free DHA, MFn alone, or their combinations with irradiation.  \nConclusion: This multifunctional biomimetic nanoplatform presents a promising strategy for precise, multimodal ovarian cancer therapy. By integrating controlled drug delivery, catalytic Fenton-like reactions, and synergistic radiotherapy, DHA@MFn demonstrates significant potential for clinical translation in targeted cancer treatment","cbCaikVgGPpdWeH2","https://ap.wps.com/l/cbCaikVgGPpdWeH2","pdf",16358047,"English","# Introduction\n## Purpose\n## Methods\n## Results\n## Conclusion","[{\"question\":\"What problem does the study aim to solve with ferritin-based delivery?\",\"answer\":\"Ferritin accumulates nonspecifically in iron-metabolizing organs, which reduces targeting accuracy and therapeutic effectiveness for ovarian cancer treatment.\"},{\"question\":\"How was the DHA@MFn nanoplatform constructed and evaluated?\",\"answer\":\"A manganese-mineralized ferritin nanocage was used to encapsulate dihydroartemisinin, forming DHA@MFn, whose physicochemical properties and stimuliresponsiveness and in vitro release were assessed under weakly acidic conditions.\"},{\"question\":\"What mechanisms drive the antitumor effect of DHA@MFn?\",\"answer\":\"Mn2+ released by DHA@MFn catalyzes Fenton-like reactions for hydroxyl radical production, while DHA triggers ferroptosis through lipid peroxidation and GSH depletion, and irradiation further enables synergistic multimodal therapy.\"}]","Manganese Biomineralized Ferritin Nanoplatforms with Shielding and Stimuli-Responsive Release for Potentiated Ferroptosis and Multimodal Ovarian Cancer Therapy | PDF",1790100728,48]