[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-detail-27138-en":3,"doc-seo-27138-105":28,"detail-sidebar-cat-0-en-105":71},{"code":4,"msg":5,"data":6},0,"success",{"doc_id":7,"user_id":8,"nickname":9,"user_avatar":10,"doc_module":4,"category_id":11,"category_name":12,"doc_title":13,"doc_description":14,"doc_content":15,"file_id":16,"file_url":17,"file_type":18,"file_size":19,"view_count":4,"is_deleted":4,"is_public":20,"is_downloadable":20,"audit_status":20,"page_count":21,"language":22,"language_code":23,"site_id":24,"html_lang":23,"table_of_contents":15,"faqs":15,"seo_title":25,"seo_description":14,"update_tm":26,"read_time":27},27138,1374391975076,"Riley","https://ap-avatar.wpscdn.com/avatar/14000253ca4ec9f6853?x-image-process=image/resize,m_fixed,w_180,h_180&k=1783305029341752051",7,"Healthcare","Management of Tuberculosis (TB) World Health Organization Recommendations","This document outlines the World Health Organization's (WHO) recommendations for the treatment of new tuberculosis (TB) cases, focusing on both intensive and continuation phases of standard regimens. The intensive phase typically lasts for 2 months, utilizing HRZE (Isoniazid, Rifampicin, Pyrazinamide, Ethambutol) or HRE (Isoniazid, Rifampicin, Ethambutol) in specific scenarios, such as in countries with high levels of isoniazid resistance where drug susceptibility testing is unavailable. The continuation phase extends for 4 months with HR or HRE. Dosing frequency recommendations are also provided, with daily dosing being optimal for preventing acquired drug resistance. For patients receiving directly observed therapy (DOT), a 3 times/week regimen is not longer recommended but may be used in practice under certain conditions, particularly for individuals not living with HIV or in an HIV-prevalent setting. The document elaborates on general management principles, including routine blood tests, viral hepatitis screening, and HIV testing before initiating treatment. Standard treatment duration for fully sensitive TB is 6 months, extended to at least 12 months for TB infection of the central nervous system (CNS). Quadruple therapy, consisting of Isoniazid, Rifampicin, Pyrazinamide, and Ethambutol, is the first-line approach, with fixed-dose combinations preferred. Adjunctive corticosteroid therapy is advised in specific conditions like CNS disease, pericardial disease, endobronchial disease in children, and to reduce long-term complications such as fibrosis. Additionally, corticosteroids are beneficial for pleural, ureteric, and extensive pulmonary disease, and to suppress hypersensitivity reactions. Directly observed therapy (DOT) is recommended for patients with concerns about treatment adherence or difficulties in medication intake, including those with serious mental illness, MDR TB, homelessness, imprisonment, alcoholism, and drug abuse. Indications for hospital admission in TB patients are also detailed, encompassing uncertainty in diagnosis, medication intolerance, questionable adherence, and a significant risk of multidrug-resistant TB. Finally, crucial advice for patients receiving anti-TB medication is provided, covering potential side effects such as urine and secretion discoloration (due to Rifampicin), the need to change oral contraception methods, cessation of smoking and alcohol consumption, and seeking immediate medical attention for symptoms like nausea, vomiting, or jaundice.","","cbCaif5pWpKZ8GF8","https://ap.wps.com/l/cbCaif5pWpKZ8GF8","pdf",1657572,1,25,"English","en",105,"Management of Tuberculosis (TB) World Health Organization Recommendations | PDF",1778201683,63,{"code":4,"msg":29,"data":30},"ok",{"site_id":24,"language":23,"slug":31,"title":13,"keywords":15,"description":14,"schema_data":32,"social_meta":66,"head_meta":68,"extra_data":70,"updated_unix":26},"management-of-tuberculosis-tb-world-health-organization-recommendations",{"@graph":33,"@context":65},[34,51],{"@type":35,"itemListElement":36},"BreadcrumbList",[37,41,45,48],{"item":38,"name":39,"@type":40,"position":20},"https://docshare.wps.com","Home","ListItem",{"item":42,"name":43,"@type":40,"position":44},"https://docshare.wps.com/document/","Document",2,{"item":46,"name":12,"@type":40,"position":47},"https://docshare.wps.com/document/healthcare/",3,{"item":49,"name":13,"@type":40,"position":50},"https://docshare.wps.com/document/management-of-tuberculosis-tb-world-health-organization-recommendations/27138",4,{"url":49,"name":13,"@type":52,"author":53,"headline":13,"publisher":55,"fileFormat":58,"description":14,"dateModified":59,"datePublished":59,"encodingFormat":58,"isAccessibleForFree":60,"interactionStatistic":61},"DigitalDocument",{"name":9,"@type":54},"Person",{"url":38,"name":56,"@type":57},"DocShare","Organization","application/pdf","2026-05-08",true,{"@type":62,"interactionType":63,"userInteractionCount":4},"InteractionCounter",{"@type":64},"ViewAction","https://schema.org",{"og:url":49,"og:type":67,"og:title":13,"og:site_name":56,"og:description":14},"article",{"robots":69,"canonical":49},"index,follow",{"doc_id":7,"site_id":24},{"code":4,"msg":5,"data":72},[73,77,81,85,90,95,98,103,108,111,115],{"id":20,"doc_module":4,"doc_module_name":43,"category_name":74,"show_sort_weight":75,"slug":76},"Story & Novel",90,"story-novel",{"id":44,"doc_module":4,"doc_module_name":43,"category_name":78,"show_sort_weight":79,"slug":80},"Literature",80,"literature",{"id":50,"doc_module":4,"doc_module_name":43,"category_name":82,"show_sort_weight":83,"slug":84},"Exam",70,"exam",{"id":86,"doc_module":4,"doc_module_name":43,"category_name":87,"show_sort_weight":88,"slug":89},5,"Comic",60,"comic",{"id":91,"doc_module":4,"doc_module_name":43,"category_name":92,"show_sort_weight":93,"slug":94},6,"Technology",50,"technology",{"id":11,"doc_module":4,"doc_module_name":43,"category_name":12,"show_sort_weight":96,"slug":97},40,"healthcare",{"id":99,"doc_module":4,"doc_module_name":43,"category_name":100,"show_sort_weight":101,"slug":102},8,"Research & Report",30,"research-report",{"id":104,"doc_module":4,"doc_module_name":43,"category_name":105,"show_sort_weight":106,"slug":107},9,"Religion & Spirituality",20,"religion-spirituality",{"id":106,"doc_module":4,"doc_module_name":43,"category_name":109,"show_sort_weight":106,"slug":110},"World Cup","world-cup",{"id":112,"doc_module":4,"doc_module_name":43,"category_name":113,"show_sort_weight":112,"slug":114},10,"Lifestyle","lifestyle",{"id":116,"doc_module":4,"doc_module_name":43,"category_name":117,"show_sort_weight":86,"slug":118},19,"General","general"]