[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-371694-105":59,"doc-detail-371694-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","management-of-myeloproliferative-neoplasms-an-integrative-approach","Management of Myeloproliferative Neoplasms - An Integrative Approach","","Myeloproliferative neoplasms (MPNs) are chronic blood cancers marked by excessive blood-cell production, increasing thrombotic and ischemic risk. Patients commonly report fatigue, abdominal discomfort, and complications that substantially reduce quality of life, while many seek complementary and integrative medicine (CIM). This review evaluates the evidence for integrative strategies in MPN management, emphasizing nutrition, microbiota, supplements, mind-body approaches, and acupuncture, with attention to safety, anti-inflammatory effects, symptom relief, and treatment tolerance to support clinician decision-making for safe adjunctive care.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/management-of-myeloproliferative-neoplasms-an-integrative-approach/371694/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/management-of-myeloproliferative-neoplasms-an-integrative-approach/371694.png","ImageObject",300,407,{"name":92,"@type":93},"Adam","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-27","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",14,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What are myeloproliferative neoplasms (MPNs) and why do they matter clinically?","Question",{"text":113,"@type":114},"MPNs are chronic blood cancers involving overproduction of blood cells, leading to elevated thrombotic and ischemic risk and a broad symptom burden that affects quality of life.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"Which complementary and integrative medicine (CIM) approaches are discussed for MPN management?",{"text":118,"@type":114},"The review focuses on nutrition, microbiota-related approaches, supplements, mind–body techniques, and acupuncture, aiming to understand evidence and safety for integration with conventional care.",{"name":120,"@type":111,"acceptedAnswer":121},"Why is evidence-based integration of CIM into routine clinical practice emphasized?",{"text":122,"@type":114},"CIM use is often undisclosed, raising concerns about fragmented care, safety, and insufficient evidence-based integration into clinical workflows, especially as many available data are preclinical with few clinical trials.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},371694,1790437270,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146},1374404737137,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","Review  \nManagement of Myeloproliferative Neoplasms: An Integrative Approach  \nFrancesca Andreazzoli 1,2,*, Ilana Levy Yurkovski 3,4, Krisstina Gowin 5,† and Massimo Bonucci 2,†  \nAcademic Editors: Alicia Rovo and Arumugam Manoharan  \nReceived: 10 May 2025  \nRevised: 13 July 2025  \nAccepted: 15 July 2025  \nPublished: 17 July 2025  \nCitation: Andreazzoli, F.; Levy Yurkovski, I.; Gowin, K.; Bonucci, M. Management of Myeloproliferative Neoplasms: An Integrative Approach.  \nJ. Clin. Med. 2025, 14, 5080. [https://](https://)[ ](https://)[doi.org/10.3390/jcm14145080](doi.org/10.3390/jcm14145080)  \n[Copyright:](Copyright:) © 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://creativecommons.org/](https://creativecommons.org/)[ ](https://creativecommons.org/)[licenses/by/4.0/](licenses/by/4.0/)) .  \n1 Hematology Department, North West Tuscany Hospital, 55041 Lucca, Italy  \n2 ARTOI Foundation, Via Ludovico Micara, 73, 00165 Rome, Italy; [maxbonucci@artoi.it](maxbonucci@artoi.it)  \n3 Hematology Unit, Bnai Zion Medical Center, Haifa 3339419, Israel; [ilana.e.levy@gmail.com](ilana.e.levy@gmail.com)  \n4 Rappaport Faculty of Medicine, Technion—Israel Institute of Technology, Haifa 3200003, Israel  \n5 Departments of Supportive Care and Hematology Hematopoietic Transplant, City of Hope Comprehensive Cancer Center, Irvine, CA 91010, USA; [kgowin@coh.org](kgowin@coh.org)  \n* Correspondence: [francescandreazzoli@gmail.com](francescandreazzoli@gmail.com)  \n† These authors contributed equally to this work.  \nAbstract  \nMyeloproliferative neoplasms (MPNs) are chronic blood cancers characterized by overproduction of blood cells, leading to increased thrombotic and ischemic risk. Patients frequently experience symptoms including fatigue, abdominal discomfort, and complications from thrombotic events, which significantly impact the quality of life (QoL). Many patients inquire about complementary and integrative medicine (CIM) approaches, including nutritional interventions and supplements, creating opportunities for healthcare providers to engage in meaningful discussions guided by the principle of safety. This review examines the current evidence for integrative approaches in MPN management, focusing on nutrition, microbiota, supplements, mind–body techniques, and acupuncture. We analyze the available data on anti-inflammatory interventions, QoL improvement strategies, and treatment tolerance enhancement. The review provides clinicians with evidence-based guidance for safely integrating complementary therapeutic approaches with conventional MPN treatment. This integrative approach represents an opportunity to develop more comprehensive and personalized therapeutic paradigms in hematology while ensuring that complementary interventions serve as adjuncts to evidence-based medical treatment.  \nKeywords: myeloproliferative neoplasms; integrative hematology; acupuncture; mind–body therapies; microbiota  \n1. Introduction  \nMyeloproliferative neoplasms (MPNs), including polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF), are clonal hematopoietic stem cell disorders characterized by dysregulated hematopoiesis, chronic inflammation, and a variable risk of progression to acute leukemia [1,2] . Although therapeutic advancements have led to improved disease control and extended survival in some cases, MPNs remain incurable for most patients [3] .  \nA central challenge in the management of MPNs is the high burden of physical and psychological symptoms, such as fatigue, pruritus, sleep disturbance, early satiety, mood disorders, and cognitive impairment. These symptoms are prevalent across disease subtypes and stages, often persist despite pharmacologic therapy, and significantly impair  \npatients’ quality of life [4–6] . Conventional treatments, particularly the use of JAK inhibit","cbCaiadvqWIrm4Bi","https://ap.wps.com/l/cbCaiadvqWIrm4Bi","pdf",562962,21,"English","# Abstract\n# Introduction\n## Symptom burden and conventional limitations\n## Role of CIM and resilience\n## Integrative oncology and integrative hematology frameworks\n## Purpose and scope of the narrative review","[{\"question\":\"What are myeloproliferative neoplasms (MPNs) and why do they matter clinically?\",\"answer\":\"MPNs are chronic blood cancers involving overproduction of blood cells, leading to elevated thrombotic and ischemic risk and a broad symptom burden that affects quality of life.\"},{\"question\":\"Which complementary and integrative medicine (CIM) approaches are discussed for MPN management?\",\"answer\":\"The review focuses on nutrition, microbiota-related approaches, supplements, mind–body techniques, and acupuncture, aiming to understand evidence and safety for integration with conventional care.\"},{\"question\":\"Why is evidence-based integration of CIM into routine clinical practice emphasized?\",\"answer\":\"CIM use is often undisclosed, raising concerns about fragmented care, safety, and insufficient evidence-based integration into clinical workflows, especially as many available data are preclinical with few clinical trials.\"}]","Management of Myeloproliferative Neoplasms - An Integrative Approach | PDF",1790192637,53]