[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-384611-105":59,"doc-detail-384611-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","malignancy-diseases-and-kidneys-a-nephrologist-prospect-and-updated-review","Malignancy diseases and kidneys - A nephrologist prospect and updated review","","Acute kidney injury (AKI), chronic renal failure, and tubular abnormalities form a malignancy-associated kidney disease spectrum. Cancer-related AKI shows multifactorial pathogenesis and worsens outcomes, including higher hospitalization rates and treatment withdrawal. Early detection and targeted management can restore renal function and improve survival, especially by identifying patients at higher risk for renal damage and applying prevention without losing oncologic benefits. Relief of obstruction, hydration, and multidisciplinary care help reduce injury rates. The review summarizes cancer-associated kidney complications, pathogenesis, management, prevention, and recent updates. Kidney involvement may result from tumor therapy, direct renal invasion, or tumor complications. Early diagnosis and therapy improve survival; a kidney biopsy can confirm kidney pathology. Strategies to prevent involvement include avoiding nephrotoxic drugs, standardizing dosing, and promoting early cancer detection.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/malignancy-diseases-and-kidneys-a-nephrologist-prospect-and-updated-review/384611/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/malignancy-diseases-and-kidneys-a-nephrologist-prospect-and-updated-review/384611.png","ImageObject",300,407,{"name":92,"@type":93},"Ivy","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-27","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What kidney complications are associated with malignancy in this review?","Question",{"text":112,"@type":113},"The review highlights acute kidney injury (AKI), chronic renal failure/chronic kidney disease, and tubular abnormalities as the core malignancy-related kidney disease spectrum.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Why does cancer increase the risk of acute kidney injury (AKI)?",{"text":117,"@type":113},"AKI risk is driven by patient-related risk factors similar to the general population, tumor-related mechanisms like compression or direct renal infiltration, and treatment-related factors such as tumor lysis syndrome, venous-occlusive disease, and thrombotic microangiopathy.",{"name":119,"@type":110,"acceptedAnswer":120},"How can clinicians reduce renal damage while maintaining cancer therapy benefits?",{"text":121,"@type":113},"The review emphasizes early detection and targeted, preventive measures, including multidisciplinary interventions (e.g., relieving obstruction and hydration), avoiding nephrotoxic drugs, and standardizing dosing.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},384611,1790539746,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},549758252649,"https://ap-avatar.wpscdn.com/avatar/8000253669c5317157?_k=1778319167496531819","®  \n Narrative Review   \nMalignancy diseases and kidneys A nephrologist prospect and updated review  \nElmukhtar Habas, PhD, MDa,*  , Raza Akbar, MRCP, FRCPb , Kalifa Farfar, MBBCHc , Nada Arrayes, MBChBd , Aml Habas, MBChBe , Amnna Rayani, MBBCHf , Gamal Alfitori, MRCP, FRCPb , Eshrak Habas, MBBCHg , Yaqeen Magassabi, Studenth , Hafidh Ghazouani, MSci , Aisha Aladab, MDj ,  \nAbdel-Naser Elzouki, MBChB, DTM&H, MSc, MD, PhD, FRCP (UK), FACPb  \n\n| Abstract\u003Cbr>Acute kidney injury (AKI), chronic renal failure, and tubular abnormalities represent the kidney disease spectrum of malignancy. Prompt diagnosis and treatment may prevent or reverse these complications. The pathogenesis ofAKI in cancer is multifactorial. AKI affects outcomes in cancer, oncological therapy withdrawal, increased hospitalization rate, and hospital stay. Renal function derangement can be recovered with early detection and targeted therapy of cancers. Identifying patients at higher risk of renal damage and implementing preventive measures without sacrificing the benefits of oncological therapy improve survival. Multidisciplinary approaches, such as relieving obstruction, hydration, etc. , are required to minimize the kidney injury rate. Different keywords, texts, and phrases were used to search Google, EMBASE, PubMed, Scopus, and Google Scholar for related original and review articles that serve the article’s aim well. In this nonsystematic article, we aimed to review the published data on cancer-associated kidney complications, their pathogenesis, management, prevention, and the latest updates. Kidney involvement in cancer occurs due to tumor therapy, direct kidney invasion by tumor, or tumor complications. Early diagnosis and therapy improve the survival rate. Pathogenesis of cancer-related kidney involvement is different and complicated. Clinicians’ awareness of all the potential causes of cancer-related complications is essential, and a kidney biopsy should be conducted to confirm the kidney pathologies. Chronic kidney disease is a known complication in malignancy and therapies. Hence, avoiding nephrotoxic drugs, dose standardization, and early cancer detection are mandatory measures to prevent renal involvement. |\n| --- |\n| Abbreviations: AIN = acute interstitial necrosis, AKI = acute kidney injury, ANCA = antineutrophil cytoplasmic antibody, AQP2 = aquaporin 2, ATI = acute tubular injury, CKD = chronic kidney disease, eGFR = estimated glomerular filtration rate, ESRD = endstage renal disease, FLC = free light chain, HRS = hepatorenal syndrome, HSCT = hematopoietic stem cell transplantation, HTN = hypertension, IL = interleukin, MM = multiple myeloma, RIFLE = Risk, Injury, Failure, Loss of kidney function, and End-stage kidney disease, RRT = renal replacement therapy, TLS = tumor lysis syndrome, TMA = thrombotic microangiopathy, TPE = therapeutic plasma exchange, VOD = venous-occlusive disease. |\n| Keywords: AKI, cancer-induced AKI, HSCT, hyperphosphatemia, hyperuricemia, TLS, TMA |\n\n1. Introduction  \nAcute kidney injury (AKI) is a frequent complication of cancers that can affect up to 50% of the patients during their course of cancer. It significantly influences the overall prognosis, duration of hospitalization, and consequent healthcare  \nThe authors have no funding and conflicts of interest to disclose.  \nData sharing not applicable to this article as no datasets were generated or analyzed during the current study.  \nThis article is a nonsystematic review article. It had no intervention, and there was no animal or human involvement.  \na Facharzt Internal Medicine, Facharzt Nephrology, Medical Department, Hamad General Hospital, Doha, Qatar, b Medical Department, Hamad General Hospital, Doha, Qatar, c Facharzt Internal Medicine, Medical Department, Alwakra General Hospital, Alwakra, Qatar, d Medical Education Fellow, Lincoln Medical School, University of Lincoln, Lincoln, UK, e Hematology-Oncology Department, Tripoli Children Hospital, Tripoli, Libya, f ","cbCaiuQk4YJq1905","https://ap.wps.com/l/cbCaiuQk4YJq1905","pdf",658272,13,"English","# Introduction\n# Acute kidney injury in cancer\n## Patient-, tumor-, and treatment-related risk factors\n# Kidney involvement in malignancy\n## Pathogenesis, diagnosis, and management","[{\"question\":\"What kidney complications are associated with malignancy in this review?\",\"answer\":\"The review highlights acute kidney injury (AKI), chronic renal failure/chronic kidney disease, and tubular abnormalities as the core malignancy-related kidney disease spectrum.\"},{\"question\":\"Why does cancer increase the risk of acute kidney injury (AKI)?\",\"answer\":\"AKI risk is driven by patient-related risk factors similar to the general population, tumor-related mechanisms like compression or direct renal infiltration, and treatment-related factors such as tumor lysis syndrome, venous-occlusive disease, and thrombotic microangiopathy.\"},{\"question\":\"How can clinicians reduce renal damage while maintaining cancer therapy benefits?\",\"answer\":\"The review emphasizes early detection and targeted, preventive measures, including multidisciplinary interventions (e.g., relieving obstruction and hydration), avoiding nephrotoxic drugs, and standardizing dosing.\"}]","Malignancy diseases and kidneys - A nephrologist prospect and updated review | PDF",1790264232,33]