[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-445800-105":59,"doc-detail-445800-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","male-survival-disadvantage-in-pulmonary-hypertension-background-methods-findings-and-interpretation","Male survival disadvantage in pulmonary hypertension - Background, Methods, Findings, and Interpretation","","Sex-based differences in morbidity and mortality in pulmonary hypertension remain underexplored, limiting precision clinical management. This study examines how sex influences survival across varying disease conditions by analyzing 21,123 incident, hemodynamically fully characterized patients from the PVRI GoDeep meta-registry. Survival was assessed using Kaplan–Meier and Cox models with sensitivity analyses. Male patients show consistently higher mortality than females across overall PH and within PAH and non-PAH groups, persisting across risk strata and therapies, with race-specific patterns.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/male-survival-disadvantage-in-pulmonary-hypertension-background-methods-findings-and-interpretation/445800/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/male-survival-disadvantage-in-pulmonary-hypertension-background-methods-findings-and-interpretation/445800.png","ImageObject",300,407,{"name":92,"@type":93},"Aurelia","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-07","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What question does the study address about sex and survival in pulmonary hypertension?","Question",{"text":112,"@type":113},"It evaluates how sex affects patient survival across different pulmonary hypertension disease conditions, focusing on differences in morbidity and mortality.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were patients selected and what dataset was used?",{"text":117,"@type":113},"The PVRI GoDeep meta-registry combined international PH registries, and the analysis included 21,123 incident, hemodynamically fully characterized patients.",{"name":119,"@type":110,"acceptedAnswer":120},"What are the key survival findings for male versus female patients?",{"text":121,"@type":113},"Male patients had significantly higher mortality than females across the overall PH population and within PAH and non-PAH groups, and the disadvantage persisted across multiple risk strata and therapies.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},445800,1790812363,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},1099514068365,"https://ap-avatar.wpscdn.com/avatar/10000253d8d9f28188e?_k=1776742907772140068","Articles  \nMale survival disadvantage in pulmonary hypertension: independent of aetiology, age, disease severity, comorbidities and treatment  \nAthiththan Yogeswaran,a,b,∗ Jeffrey S. Annis,c Meike Fünderich,a,b Jochen Wilhelm,a,b David G. Kiely,d Luke Howard,e Allan Lawrie,e  \nMartin R. Wilkins,e Aparna Balasubramanian,f Paul M. Hassoun,f Ziad Konswa,f Christina A. Eichstaedt,g,h Ekkehard Grünig,g Andrew J. Sweatt,i Roham T. Zamanian,i Gabor Kovacs,j Horst Olschewski,k Mona Lichtblau,l Silvia Ulrich,l Thenappan Thenappan,m Imad Al Ghouleh,n Stephen Y. Chan,o Jean Elwing,p Arun Jose,p John Cannon,q Joanna Pepke-Zaba,q Robert Frantz,r Yuriy Sirenko,s Olena Torbas,s Sandeep Sahay,t,w Zhenguo Zhai,u Zhu Zhang,u Alexandra Arvanitaki,v George Giannakoulas,v Marlize Frauendorf,w Paul G. Williams,w Keiichiro Kuronuma,x Hiromi Matsubara,x Stefano Ghio,y Laura Scelsi,y Hanni Sabbour,z Khaled Saleh,z Anastasia Anthi,aa Effrosyni Dima,aa Raphael W. Majeed,a,b,ab Hossein-Ardeschir Ghofrani,a,b Friedrich Grimminger,a,b Khodr Tello,a,b,ac Hector R. Cajigas,r,ac Evan Brittain,c,ac and Werner Seeger,a,b,∗∗,ac The PVRI Consortiumad  \naDepartment of Internal Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Giessen, Germany  \nbInstitute for Lung Health (ILH), Cardio-Pulmonary Institute (CPI), Giessen, Germany  \ncVanderbilt University Medical Center, Nashville, USA  \ndSheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, University of Sheffield and National Institute for Health and Care Research Sheffield Biomedical Research Centre, UK  \neNational Heart and Lung Institute, Imperial College London, London, UK  \nfDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, USA  \ngCenter for Pulmonary Hypertension, Thoraxklinik Heidelberg gGmbH at Heidelberg University Hospital and Translational Lung Research Center Heidelberg (TLRC), German Center for Lung Research (DZL), Heidelberg, Germany  \nhLaboratory for Molecular Genetic Diagnostics, Institute of Human Genetics, Heidelberg University, Heidelberg, Germany iDivision of Pulmonary, Allergy, and Critical Care, and Vera Moulton Wall Center for Pulmonary Vascular Disease, Stanford University, USA  \njDivision of Respiratory Medicine, Lung Research Cluster, Medical University of Graz, Graz, Austria  \nkCharité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Infectious Diseases and Respiratory Medicine, Berlin, Germany  \nlDivision of Pulmonology, University Hospital Zurich, Switzerland  \nmUniversity of Minnesota, USA  \nnCardiovascular Research Center, Brown University Health Cardiovascular Institute, Department of Medicine, The Warren Alpert Medical School of Brown University, USA  \noUniversity of Pittsburgh, USApUniversity of Cincinnati, USA  \nqRoyal Papworth Hospital Cambrigde, UK  \nrDivision of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, USA sStrazhensku Cardiology Institute Kiev, Ukraine  \ntThe Methodist, Houston, USA  \nuDepartment of Respiratory and Critical Care Medicine, China-Japan Friendship Hospital, Beijing, China v1th Department of Cardiology, Aristotle University of Thessaloniki, Greece  \nwMilpark Hospital, Johannesburg, ZA, South Africa  \nxPulmonary Hypertension Center, Department of Cardiology, NHO Okayama Medical Center, Okayama, Japan yUniversity di Pavia, Italy  \nzCleveland Clinic Abu Dhabi, United Arab Emirates aaEvangelismos Hospital Athens, Greece  \nabInstitute of Medical Informatics, RWTH Aachen University, Aachen, Germany  \n*Corresponding author. Department of Internal Medicine, Justus-Liebig-University Giessen, Klinikstrasse 32, 35392, Giessen, Germany.  \n**Corresponding author. Department of Internal Medicine, Justus-Liebig-University Giessen, Klinikstrasse 32, 35392, Giessen, Germany.  \nE-mail [addresses:](addresses: Athiththan.Yoges","cbCaihy4j1XSrrM0","https://ap.wps.com/l/cbCaihy4j1XSrrM0","pdf",4000916,15,"English","# Summary\n## Background\n## Methods\n## Findings\n## Interpretation","[{\"question\":\"What question does the study address about sex and survival in pulmonary hypertension?\",\"answer\":\"It evaluates how sex affects patient survival across different pulmonary hypertension disease conditions, focusing on differences in morbidity and mortality.\"},{\"question\":\"How were patients selected and what dataset was used?\",\"answer\":\"The PVRI GoDeep meta-registry combined international PH registries, and the analysis included 21,123 incident, hemodynamically fully characterized patients.\"},{\"question\":\"What are the key survival findings for male versus female patients?\",\"answer\":\"Male patients had significantly higher mortality than females across the overall PH population and within PAH and non-PAH groups, and the disadvantage persisted across multiple risk strata and therapies.\"}]","Male survival disadvantage in pulmonary hypertension - Background, Methods, Findings, and Interpretation | PDF",1790712747,38]