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Conditions including varicocele, obstructive azoospermia, erectile dysfunction, and Peyronie’s disease impair fertility through distinct mechanisms such as impaired spermatogenesis, reproductive tract obstruction, and failed sperm delivery. Management relies on systematic diagnosis using history, examination, semen analysis, and specialized imaging, progressing from lifestyle measures to targeted medical or surgical interventions and, when needed, assisted reproduction.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/male-infertility-a-comprehensive-review-of-urological-causes-and-contemporary-management/461599/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/male-infertility-a-comprehensive-review-of-urological-causes-and-contemporary-management/461599.png","ImageObject",300,407,{"name":92,"@type":93},"PakDamar76","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-08","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Which urological conditions are highlighted as common, correctable causes of male infertility?","Question",{"text":112,"@type":113},"The article emphasizes varicocele, obstructive azoospermia, erectile dysfunction, and Peyronie’s disease as major urological contributors.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How does the article recommend diagnosing male infertility?",{"text":117,"@type":113},"Diagnosis should combine clinical history, physical examination, semen analysis, and specialized imaging as part of a systematic evaluation.",{"name":119,"@type":110,"acceptedAnswer":120},"What is the overall treatment pathway described for these urological causes?",{"text":121,"@type":113},"Management progresses from foundational lifestyle modifications to targeted medical or surgical interventions, and culminates in assisted reproductive technologies when necessary.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},461599,1790968395,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},962090893057,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","Review  \nMale Infertility: A Comprehensive Review of Urological Causes and Contemporary Management  \nBiagio Barone 1, *, Ugo Amicuzi 2, Simone Tammaro 2, Michelangelo Olivetta 3, Marco Stizzo 4,  \nMichele Musone 2, Luigi Napolitano 2, Luigi De Luca 5, Pasquale Reccia 6, Federico Capone 2, Arturo Lecce 2, Giovanni Pagano 2, Silvestro Imperatore 2, Stefano Chianese 2, Salvatore Papi 2, Giampiero Della Rosa 2, Fabrizio Dinacci 2, Mariano Coppola 2, Antonio Madonna 2, Marco Grillo 1, Dante Di Domenico 1,  \nFrancesco Del Giudice 7, Vincenzo Francesco Caputo 8, Dario Del Biondo 1, Roberto Falabella 8 and Felice Crocetto 2  \nAcademic Editor: Manesh Kumar Panner Selvam  \nReceived: 21 November 2025  \nRevised: 21 December 2025  \nAccepted: 1 January 2026  \nPublished: 5 January 2026  \nCopyright: © 2026 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.  \n1 Department of Urology, P.O. San Paolo, ASL Napoli 1 Centro, 80145 Naples, Italy;  \n[grillomarco@inwind.it](grillomarco@inwind.it) (M.G.); [dantedid@gmail.com](dantedid@gmail.com) (D.D.D.); [dario.delbiondo@aslnapoli1centro.it](dario.delbiondo@aslnapoli1centro.it) (D.D.B.)  \n2 Department of Neurosciences, Sciences of Reproduction and Odontostomatology, University of Naples  \nFederico II, 80131 Naples, Italy; [u.amicuzi@gmail.com](u.amicuzi@gmail.com) (U.A.); [simone.tammaro95@gmail.com](simone.tammaro95@gmail.com) (S.T.);  \n[drmichelemusone@gmail.com](drmichelemusone@gmail.com) (M.M.); [nluigi89@libero.it](nluigi89@libero.it) (L.N.); [fedecapone@outlook.it](fedecapone@outlook.it) (F.C.);  \n[arturo.lecce92@gmail.com](arturo.lecce92@gmail.com) (A.L.); [giovanni.pagano1@outlook.it](giovanni.pagano1@outlook.it) (G.P.); [silvestro.imperatore97@gmail.com](silvestro.imperatore97@gmail.com) (S.I.);  \n[stechianese99@gmail.com](stechianese99@gmail.com) (S.C.); [salvatorepapi@blu.it](salvatorepapi@blu.it) (S.P.); [giampierodellarosa@gmail.com](giampierodellarosa@gmail.com) (G.D.R.);  \n[fabrizio.dinacci18@gmail.com](fabrizio.dinacci18@gmail.com) (F.D.); [marianocoppola99@icloud.com](marianocoppola99@icloud.com) (M.C.);  \n[antoniomadonna1997@icloud.com](antoniomadonna1997@icloud.com) (A.M.); [felice.crocetto@unina.it](felice.crocetto@unina.it) (F.C.)  \n3 Urology Unit, Department of Surgical Sciences, AORN Sant’Anna e San Sebastiano, 81100 Caserta, Italy; [olivetta.drmichelangelo@gmail.com](olivetta.drmichelangelo@gmail.com)  \n4 Urology Unit, Department of Woman, Child and General and Specialized Surgery, University of Campania Luigi Vanvitelli, 80131 Naples, Italy; [marcostizzo@hotmail.com](marcostizzo@hotmail.com)  \n5 Division of Urology, Department of Surgical Multispecialty, AORN Antonio Cardarelli, 80131 Naples, Italy; [luigideluca86@gmail.com](luigideluca86@gmail.com)  \n6 Urology Unit, AORN Ospedali dei Colli, Monaldi Hospital, 80131 Naples, Italy; [reccia.pasquale1@gmail.com](reccia.pasquale1@gmail.com)  \n7 Department of Urology, University Sapienza, 00185 Rome, Italy; [francesco.delgiudice@uniroma1.it](francesco.delgiudice@uniroma1.it)  \n8 Unit of Urology, San Carlo Hospital, 85100 Potenza, Italy; [vincitor@me.com](vincitor@me.com) (V.F.C.); [rfalabella@libero.it](rfalabella@libero.it) (R.F.)  \n* [Correspondence: biagio.barone@aslnapoli1centro.it](Correspondence: biagio.barone@aslnapoli1centro.it)  \nAbstract  \nMale infertility is a prevalent global health issue, with urological disorders representing some of the most common and correctable causes. Key conditions such as varicocele, obstructive azoospermia, erectile dysfunction and Peyronie’s disease impair fertility through distinct pathophysiological mechanisms, including disrupted spermatogenesis, reproductive tract obstruction and failed sperm delivery. The effective management of these conditions hinges on a systematic diagnostic evaluation, which integrates clinical history, physical examination, semen ana","cbCaicTtaTqQsqeJ","https://ap.wps.com/l/cbCaicTtaTqQsqeJ","pdf",573194,21,"English","# Introduction\n## Epidemiology and shift toward male-focused fertility care\n## Multifactorial causes and role of urological disorders\n## Diagnostic framework for male infertility\n## Contemporary management strategies\n## Evidence-based lifestyle and multidisciplinary approaches","[{\"question\":\"Which urological conditions are highlighted as common, correctable causes of male infertility?\",\"answer\":\"The article emphasizes varicocele, obstructive azoospermia, erectile dysfunction, and Peyronie’s disease as major urological contributors.\"},{\"question\":\"How does the article recommend diagnosing male infertility?\",\"answer\":\"Diagnosis should combine clinical history, physical examination, semen analysis, and specialized imaging as part of a systematic evaluation.\"},{\"question\":\"What is the overall treatment pathway described for these urological causes?\",\"answer\":\"Management progresses from foundational lifestyle modifications to targeted medical or surgical interventions, and culminates in assisted reproductive technologies when necessary.\"}]","Male Infertility - A Comprehensive Review of Urological Causes and Contemporary Management | PDF",1790761946,53]