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MALAT1-linked coding programs reflected oncogenic pathways driven by the lymph node microenvironment, and high MALAT1 in FL predicted shorter progression-free survival.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/malat1-expression-is-associated-with-aggressive-behavior-in-indolent-b-cell-neoplasms/382924/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/malat1-expression-is-associated-with-aggressive-behavior-in-indolent-b-cell-neoplasms/382924.png","ImageObject",300,407,{"name":42,"@type":43},"supergirl","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-30","2026-09-24",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",13,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"How was MALAT1 expression measured in the study?","Question",{"text":63,"@type":64},"MALAT1 expression was analyzed using RNA-seq, microarrays, and qRT-PCR in primary samples from CLL, paired RT, and FL cohorts.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"What clinical association was found for high MALAT1 in CLL peripheral blood?",{"text":68,"@type":64},"High MALAT1 expression in peripheral blood CLL was associated with a significantly shorter time to treatment, independently of other known prognostic factors.",{"name":70,"@type":61,"acceptedAnswer":71},"How did MALAT1 levels differ between CLL and Richter transformation samples?",{"text":72,"@type":64},"MALAT1 levels were lower in Richter transformation (RT) samples compared with the associated CLL samples, consistent with increased independence from external 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aggressive behavior in indolent B‑cell neoplasms  \nElena María Fernández‑Garnacho1, Ferran Nadeu1,2, Silvia Martín1, Pablo Mozas1,3, Andrea Rivero1,3, Julio Delgado1,2,3, Eva Giné1,2,3, Armando López‑Guillermo1,2,3,  \nMartí Duran‑Ferrer1, Itziar Salaverria1,2, Cristina López1,2, Sílvia Beà1,2,3, Santiago Demajo1, Pedro Jares1,2,3, Xose S. Puente2,4, José Ignacio Martín‑Subero1,2,5, Elías Campo1,2,3 & Lluís Hernández1,2*  \nMALAT1 long non‑coding RNA has oncogenic roles but has been poorly studied in indolent B‑cell neoplasms. Here, MALAT1 expression was analyzed using RNA‑seq, microarrays or qRT‑PCR in primary samples from clinico‑biological subtypes of chronic lymphocytic leukemia (CLL, n = 266), paired Richter transformation (RT, n = 6) and follicular lymphoma (FL, n = 61). In peripheral blood (PB) CLL samples, high MALAT1 expression was associated with a significantly shorter time to treatment independently from other known prognostic factors. Coding genes expressed in association with MALAT1 inCLL were predominantly related to oncogenic pathways stimulated in the lymph node (LN) microenvironment. In RT paired samples, MALAT1 levels were lower, concordant with their acquired increased independency of external signals. Moreover, MALAT1 levels in paired PB/LN CLLs were similar, suggesting that the prognostic value of MALAT1 expression in PB is mirroring expression differences already present in LN. Similarly, high MALAT1 expression in FL predicted for a shorter progression‑free survival, in association with expression pathways promoting FL pathogenesis. In summary, MALAT1 expression is related to pathophysiology and more aggressive clinical behavior of indolent B‑cell neoplasms. Particularly in CLL, its levels could be a surrogate marker of the microenvironment stimulation and may contribute to refine the clinical management of these patients.  \nLong non-coding RNAs (lncRNAs) regulate the expression of protein-coding genes and are increasingly described as key players in physiological and pathological conditions, most remarkably in cancer1,2. One of the lncRNAs most frequently related to oncogenesis is MALAT1, which has been implicated in the regulation of key cellular pathways such as MAPK/ERK, PI3K/AKT, WNT/B-catenin, and NF-kB3 and, as a consequence, involved in many cancer-associated processes such as cell proliferation, migration, invasion, apoptosis and angiogenesis4. There are also several studies supporting MALAT1 expression as a clinical biomarker mainly associated with a poor prognosis in solid tumors3, although in some neoplasms such as diffuse large B-cell lymphoma (DLBCL), colorectal and breast cancer, high levels of MALAT1 have been linked to a favorable outcome5–7.  \nIn B-cell non-Hodgkin lymphomas (B-NHL), we and others have previously shown that lncRNA deregulation is associated with immune cell-related functions and cell proliferation control8,9. In the case of MALAT1, its expression has been shown to be upregulated in some lymphoid neoplasms such as DLBCL10, chronic lymphocytic leukemia (CLL)11, and mantle cell lymphoma (MCL)12. These results suggest that MALAT1 expression could be associated with poor prognosis even in indolent B-NHL, but most of these studies include relatively few cases and the possible clinical relevance of MALAT1 expression in these lymphoid neoplasms is still not well known. In this study, we have performed a detailed characterization of the biological and clinical impact of MALAT1 deregulation in two types of indolent B cell lymphomas with different underlying pathobiological mechanisms, namely CLL and follicular lymphoma (FL) .  \n1Lymphoid Neoplasm Program, Institut d’Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Centre Esther Koplowitz (CEK), Rosselló 153, 08036 Barcelona, Spain. 2Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain.","cbCaibV9d1WE9AvY","https://ap.wps.com/l/cbCaibV9d1WE9AvY","pdf",3664850,12,"English","# Results\n## MALAT1 expression in CLL\n## Clinical behavior association","[{\"question\":\"How was MALAT1 expression measured in the study?\",\"answer\":\"MALAT1 expression was analyzed using RNA-seq, microarrays, and qRT-PCR in primary samples from CLL, paired RT, and FL cohorts.\"},{\"question\":\"What clinical association was found for high MALAT1 in CLL peripheral blood?\",\"answer\":\"High MALAT1 expression in peripheral blood CLL was associated with a significantly shorter time to treatment, independently of other known prognostic factors.\"},{\"question\":\"How did MALAT1 levels differ between CLL and Richter transformation samples?\",\"answer\":\"MALAT1 levels were lower in Richter transformation (RT) samples compared with the associated CLL samples, consistent with increased independence from external signals.\"}]","MALAT1 expression is associated with aggressive behavior in indolent B-cell neoplasms | PDF",1790253055]