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Materials and methods: a retrospective study enrolled 84 treatment-naïve invasive breast cancer patients. TSR was estimated from tumour stroma in pathology specimens. Qualitative MRI features were evaluated using ACR-BIRADS, and quantitative parameters included STIR signal intensity, L/M ratio, and ADC. Correlation tests examined relationships between TSR and MRI findings. Results: TSR significantly correlated with mass margin, enhancement pattern, and STIR signal intensity. Conclusion: high-stroma breast cancer showed spiculated margins, lower STIR signal intensity, and heterogeneous enhancement patterns, suggesting MRI features may predict TSR.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/magnetic-resonance-imaging-features-of-invasive-breast-cancer-association-with-the-tumour-stromal-ratio-research-article/379166/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/magnetic-resonance-imaging-features-of-invasive-breast-cancer-association-with-the-tumour-stromal-ratio-research-article/379166.png","ImageObject",300,407,{"name":92,"@type":93},"นรินทร์","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-24","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What does the study evaluate regarding breast cancer?","Question",{"text":112,"@type":113},"It evaluates the association between breast cancer tumour stroma, quantified as tumour stromal ratio (TSR), and specific MRI features.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How was TSR measured in the study?",{"text":117,"@type":113},"TSR was estimated from the proportion of tumour stroma in the pathology specimen of the breast tumour.",{"name":119,"@type":110,"acceptedAnswer":120},"Which MRI features showed significant association with TSR?",{"text":121,"@type":113},"Mass margin, enhancement pattern, and STIR signal intensity significantly correlated with TSR, with additional significant associations reported for the L/M ratio.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},379166,1790528248,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":52,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},2336475104957,"https://ap-avatar.wpscdn.com/avatar/22000c4c6bd8a5076e1?x-image-process=image/resize,m_fixed,w_180,h_180&k=1787554080175789136","PLOS ONE  \nOPEN ACCESS  \nCitation: Ab Mumin N, Ramli Hamid MT, Abdul Hamid S, Chiew S-F, Ahmad Saman MS, Rahmat K (2023) Magnetic resonance imaging features of invasive breast cancer association with the tumourstromal ratio. PLoS ONE 18(8): e0290772 . [https://](https://)[ ](https://)[doi.org/10.1371/journal.pone.0290772](doi.org/10.1371/journal.pone.0290772)  \n[Editor:](Editor: Shuai Ren)[ Shuai Ren](Editor: Shuai Ren), [Affiliated Hospital of Nanjing](Affiliated Hospital of Nanjing)[ ](Affiliated Hospital of Nanjing)[University of Chinese Medicine: Jiangsu Province](University of Chinese Medicine: Jiangsu Province)[ ](University of Chinese Medicine: Jiangsu Province)Academy of Traditional Chinese Medicine, CHINA  \nReceived: March 9, 2023  \nAccepted: August 13, 2023  \nPublished: August 25, 2023  \nCopyright: © 2023 Ab Mumin et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.  \nData Availability Statement: The data underlying the results presented in the study are available from a public repository, DOI: 10.6084/m9 .  \nfigshare.22209913.  \nFunding: SAH (Dana Clinical Excellence Grant (DCEG) University Teknologi MARA: 600-HUiTM 5/ 1/DCEG (03/2021) NAM (UiTM Research grant: 600/RMC-LESTARI SDG-T5/3) The funders had no role in study design, data collection and analysis,  \nRESEARCH ARTICLE  \nMagnetic resonance imaging features of invasive breast cancer association with the tumour stromal ratio  \nNazimahAb Mumin1,2 *, Marlina Tanty Ramli Hamid1 *, Shamsiah Abdul Hamid1, Seow-Fan Chiew3, Mohd Shahril Ahmad Saman4, Kartini Rahmat2  \n1 Faculty of Medicine, Department of Radiology, Universiti Teknologi MARA, Selangor, Malaysia, 2 Faculty of Medicine, Department of Biomedical Imaging, University of Malaya, Kuala Lumpur, Malaysia, 3 Faculty of Medicine, Department of Pathology, University of Malaya, Kuala Lumpur, Malaysia, 4 Faculty of Medicine, Department of Public Health, Universiti Teknologi MARA, Selangor, Malaysia  \n* tanty301[1@yahoo.com](1@yahoo.com) (MTRH); [nazimah_mumin@uitm.edu.my](nazimah_mumin@uitm.edu.my) (NAM)  \nAbstract  \nObjective  \nTo assess the association between breast cancer tumour stroma and magnetic resonance imaging (MRI) features.  \nMaterials and methods  \nA total of 84 patients with treatment-naïve invasive breast cancer were enrolled into this retrospective study. The tumour stroma ratio (TSR) was estimated from the amount of tumourstroma in the pathology specimen of the breast tumour. The MRI images of the patients were analysed based on Breast Imaging Reporting and Data Systems (ACR-BIRADS) for qualitative features which include T2-weighted, diffusion-weighted images (DWI) and dynamic contrast-enhanced (DCE) for kinetic features. The mean signal intensity (SI) of Short Tau Inversion Recovery (STIR), with the ratio of STIR of the lesion and pectoralis muscle (L/M ratio) and apparent diffusion coefficient (ADC) value, were measured for the quantitative features. Correlation tests were performed to assess the relationship between TSR and MRI features.  \nResults  \nThere was a significant correlation between the margin of mass, enhancement pattern, and STIR signal intensity of breast cancer and TSR. There were 54 .76%(n = 46) in the low stromal group and 45 .24%(n = 38) in the high stromal group. A significant association were seen between the margin of the mass and TSR (p = 0.034) between the L/M ratio (p \u003C0.001), and between STIR SI of the lesion and TSR (p\u003C0.001) . The median L/M ratio was significantly higher in the high TSR group as compared to the lower TSR group (p \u003C 0.001) .  \ndecision to publish, or preparation of the manuscript.  \nCompeting interests: The authors have declared that no competing interests exist.  \nConclusion  \nBreast cancer with high stroma had spiculated margins, lower STIR signal intensity, and a he","cbCaie8naJJkYgeY","https://ap.wps.com/l/cbCaie8naJJkYgeY","pdf",932740,"English","# Abstract\n## Objective\n## Materials and methods\n## Results\n## Conclusion\n# Introduction\n## Breast cancer and imaging importance\n## Tumour subtypes and heterogeneity\n## Tumour stroma, CAFs, and TSR","[{\"question\":\"What does the study evaluate regarding breast cancer?\",\"answer\":\"It evaluates the association between breast cancer tumour stroma, quantified as tumour stromal ratio (TSR), and specific MRI features.\"},{\"question\":\"How was TSR measured in the study?\",\"answer\":\"TSR was estimated from the proportion of tumour stroma in the pathology specimen of the breast tumour.\"},{\"question\":\"Which MRI features showed significant association with TSR?\",\"answer\":\"Mass margin, enhancement pattern, and STIR signal intensity significantly correlated with TSR, with additional significant associations reported for the L/M ratio.\"}]","Magnetic resonance imaging features of invasive breast cancer association with the tumour stromal ratio - Research Article | PDF",1790234391,25]