[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-440485-105":59,"doc-detail-440485-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","magnesium-based-bioresorbable-flow-diverter-for-intracranial-aneurysms-a-pilot-study-of-biocompatibility-and-bioresorption-in-a-rabbit-vascular-model","Magnesium-based bioresorbable flow diverter for intracranial aneurysms: a pilot study of biocompatibility and bioresorption in a rabbit vascular model","","Bioresorbable flow diverters (BRFDs) aim to address limitations of permanent flow diverters. This research compares bare and poly-L-lactic acid (PLLA)-coated magnesium BRFDs (MgBRFDs) fabricated from a high-strength corrosion-resistant magnesium alloy. In a rabbit vascular model, constructs are evaluated for mechanical properties, structural resolution using OCT, micro-CT, and SEM, and vascular tissue responses via SEM and histopathology. Results show PLLA coating delays bioresorption and supports better stent preservation, with both types demonstrating excellent biocompatibility.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/magnesium-based-bioresorbable-flow-diverter-for-intracranial-aneurysms-a-pilot-study-of-biocompatibility-and-bioresorption-in-a-rabbit-vascular-model/440485/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/magnesium-based-bioresorbable-flow-diverter-for-intracranial-aneurysms-a-pilot-study-of-biocompatibility-and-bioresorption-in-a-rabbit-vascular-model/440485.png","ImageObject",300,407,{"name":92,"@type":93},"RuangKosong","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-02","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":14},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the goal of this pilot study of magnesium BRFDs?","Question",{"text":112,"@type":113},"The study compares bioresorption and biocompatibility between bare and PLLA-coated magnesium BRFDs in a rabbit vascular model to determine which is more clinically feasible for humans.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were the bare and PLLA-coated MgBRFDs prepared and evaluated?",{"text":117,"@type":113},"Bare and PLLA-coated MgBRFDs were braided from 48 thin magnesium alloy wires. Mechanical testing was performed, and the devices were implanted into rabbit aortas and harvested at 14, 30, and 90 days for structural and biological assessments using OCT, micro-CT, SEM, and histopathology.",{"name":119,"@type":110,"acceptedAnswer":120},"What did the study find regarding bioresorption and biocompatibility?",{"text":121,"@type":113},"Both device types showed excellent biocompatibility. The PLLA-coated MgBRFD had delayed bioresorption, better preservation of stent structure, and higher OCT attenuation scores across time points.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},440485,1790920533,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":14,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":44,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},962090883219,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","New devices and techniques  \nOriginal research  \nMagnesium-based bioresorbable flow diverter for intracranial aneurysms: a pilot study of biocompatibility and bioresorption in a rabbit vascular model  \nRyo Akiyama  , 1 Akira Ishii  ,2 Natsuhi Sasaki  ,3 So Matsukawa  , 1 Shinichi Yagi  ,4 Hideo Chihara  , 1 Hidehisa Nishi  ,2 Kiyotaka Iwasaki  ,5 Shinichi Sakurai  ,4 Yoshihito Kawamura  ,6 Yoshiki Arakawa  1  \n► Additional supplemental material is published online only. To view, please visit the journal online ([https://doi.org/](https://doi.org/)[ ](https://doi.org/)[10.1136/jnis-2024-022527](10.1136/jnis-2024-022527)) .  \n1Neurosurgery, Kyoto University Graduate School of Medicine Faculty of Medicine, Kyoto, Japan  \n2Neurosurgery, Juntendo University School of Medicine Graduate School of Medicine, Tokyo, Japan  \n3Neurosurgery, Fukui Red Cross Hospital, Fukui, Japan 4Biobased Materials Science, Kyoto Institute of Technology Faculty of Textile Science, Kyoto, Japan  \n5Cooperative Major in Advanced Biomedical Sciences, Waseda University School and Graduate School of Advanced Science and Engineering, Tokyo, Japan 6Magnesium Research Center, Kumamoto University, Kumamoto, Japan  \nCorrespondence to  \nProfessor Akira Ishii; ishiiakira@ [gmail.com](gmail.com)  \nReceived 20 September 2024 Accepted 5 November 2024  \n© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.  \nTo cite: Akiyama R, Ishii A, Sasaki N, et al. J NeuroIntervent Surg Epub ahead of print: [please include Day Month Year] . doi:10 . 1136/jnis-2024- 022527  \nABSTRACT  \nBackground Bioresorbable flow diverters (BRFDs) have the potential to solve several problems associated with conventional permanent flow diverters. We have constructed bare and poly-L-lactic acid (PLLA)-coated magnesium BRFDs (MgBRFDs) using a high-strength corrosion-resistant magnesium alloy. This study aimed to compare bioresorption and biocompatibility between the two types in a rabbit vascular model to determine which is more clinically feasible in humans.  \nMethods Bare and PLLA-coated MgBRFDs were fabricated by braiding 48 thin magnesium alloy wires. Mechanical testing was conducted. Bare (n=13) and PLLA-coated (n=13) MgBRFDs were implanted into rabbit aortas and harvested 14, 30, and 90 days after implantation. The physical structure of the resolution process was examined using optical coherence tomography (OCT), micro-computed tomography, and scanning electron microscopy (SEM) . The biological response of the vascular tissue was examined using SEM and histopathological analysis.  \nResults The porosity and pore density of the bare MgBRFD were 64% and 16 pores/mm2, respectively; corresponding values for the PLLA-coated MgBRFD were 63% and 12 pores/mm2, respectively. The OCT attenuation score was significantly higher for the PLLAcoated MgBRFD at all time points (14 days, P=0 .01; 30 days, P=0 .02; 90 days, P=0 .004) . OCT, micro-computed tomography, and SEM demonstrated better stent structure preservation with the PLLA-coated MgBRFD. Neointimal thickness did not significantly change overtime in either type of MgBRFD (bare, P=0 .93; PLLAcoated, P=0.34); however, the number of inflammatory and proliferative cells peaked at 14 days and then decreased.  \nConclusions Both bare and PLLA-coated MgBRFDs had excellent biocompatibility. The PLLA-coated MgBRFD has greater clinical feasibility because of its delayed bioresorption.  \nINTRODUCTION  \nThe introduction of flow diverters (FDs) for the treatment of unruptured intracranial aneurysms (IAs) has markedly improved patient outcomes.1–4 However, currently available FDs, constructed  \nWHAT IS ALREADY KNOWN ON THIS TOPIC  \n\n| ⇒ Bioresorbable flow diverters (BRFDs) can potentially solve the problems associated with conventional permanent flow diverters. Although magnesium is an excellent bioresorbable material, the development of a magnesium BRFD (MgBRFD) has been limited o","cbCaipSVTBJiWc68","https://ap.wps.com/l/cbCaipSVTBJiWc68","pdf",7762492,"English","# Abstract\n## Background\n## Methods\n## Results\n## Conclusions\n# Introduction\n# What is already known on this topic\n# What this study adds\n# How this study might affect research, practice or policy","[{\"question\":\"What is the goal of this pilot study of magnesium BRFDs?\",\"answer\":\"The study compares bioresorption and biocompatibility between bare and PLLA-coated magnesium BRFDs in a rabbit vascular model to determine which is more clinically feasible for humans.\"},{\"question\":\"How were the bare and PLLA-coated MgBRFDs prepared and evaluated?\",\"answer\":\"Bare and PLLA-coated MgBRFDs were braided from 48 thin magnesium alloy wires. Mechanical testing was performed, and the devices were implanted into rabbit aortas and harvested at 14, 30, and 90 days for structural and biological assessments using OCT, micro-CT, SEM, and histopathology.\"},{\"question\":\"What did the study find regarding bioresorption and biocompatibility?\",\"answer\":\"Both device types showed excellent biocompatibility. The PLLA-coated MgBRFD had delayed bioresorption, better preservation of stent structure, and higher OCT attenuation scores across time points.\"}]","Magnesium-based bioresorbable flow diverter for intracranial aneurysms: a pilot study of biocompatibility and bioresorption in a rabbit vascular model | PDF",1790692364,23]