[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-433346-105":59,"doc-detail-433346-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","madelung-disease-of-the-scrotal-region-a-case-report","Madelung Disease of the Scrotal Region - A Case Report","","Madelung disease is a rare disorder marked by symmetrical fat accumulation. A 56-year-old man presented with 10 months of dysuria and painless swelling of the lower abdomen and scrotum, with a large scrotal mass burying the penis and displacing both testes. Imaging raised suspicion for well-differentiated liposarcoma, but biopsy confirmed a benign lipoma. Excision of a 664 g lesion improved penile configuration and urination. Bilateral symmetric fat distribution should prompt consideration, since accurate diagnosis alters treatment.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/madelung-disease-of-the-scrotal-region-a-case-report/433346/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/madelung-disease-of-the-scrotal-region-a-case-report/433346.png","ImageObject",300,407,{"name":92,"@type":93},"hdkawk","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-02","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",13,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What is Madelung disease, and why is it clinically important in the scrotal region?","Question",{"text":113,"@type":114},"Madelung disease is characterized by symmetrical fat accumulation, classically around the neck, shoulders, and trunk. Scrotal involvement is exceptionally rare, and correct diagnosis is crucial because it decisively changes the treatment strategy.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How did imaging and initial diagnosis differ in this case?",{"text":118,"@type":114},"Magnetic resonance imaging suggested a well-differentiated liposarcoma, but whole-body computed tomography showed symmetrical fat accumulation in the upper trunk. Biopsy then confirmed a benign lipoma rather than malignancy.",{"name":120,"@type":111,"acceptedAnswer":121},"What treatment was performed and what was the outcome?",{"text":122,"@type":114},"Surgical excision removed a 664 g lipoma from the scrotum and lower abdomen. After surgery, the penile burying was corrected and dysuria improved, allowing the patient to urinate in a standing position.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},433346,1790717239,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":24,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":105,"preview_page_count":4},3985747859855,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","IJU Case Reports  \n CASE REPORT  OPEN ACCESS   \nMadelung Disease of the Scrotal Region: A Case Report  \nKazuki Kokura1 | Akihiro Kanematsu1  | Hideki Morisaki2 | Yasuhiro Shinkai1 | Takashi Yamasaki3 | Kenichiro Kawai2 | Masao Kakibuchi2 | Seiichi Hirota3 | Shingo Yamamoto1  \n1Department of Urology, Hyogo Medical University, Nishinomiya, Japan | 2Department of Plastic Surgery, Hyogo Medical University, Nishinomiya,  \nJapan | 3Department of Surgical Pathology, Hyogo Medical University, Nishinomiya, Japan Correspondence: Kazuki Kokura ([k.kazuki113045@gmail.com](k.kazuki113045@gmail.com))  \nReceived: 2 November 2025 | Revised: 10 December 2025 | Accepted: 29 December 2025  \nKeywords: Madelung disease | multiple symmetric lipomatosis | scrotum  \nABSTRACT  \nIntroduction: Madelung disease is a rare disorder characterized by symmetrical fat accumulation, typically around the neck, shoulders, and trunk.  \nCase Presentation: A 56-year-old man presented for 10-month history of dysuria and painless swelling of the lower abdomen and scrotum. A large scrotal mass completely buried the penis, and cranially displaced both testes. Contrast-enhanced magnetic resonance imaging suggested a well differentiated liposarcoma but whole-body computed tomography revealed symmetrical fat accumulation in the upper body trunk, raising suspicion of Madelung disease. Biopsy of the mass confirmed a benign lipoma. Excision of a 664 g lipoma improved the patient's penile configuration, enabling him to urinate in a standing position. Conclusion: Madelung disease in the scrotal region is rare, only nine cases reported to date. However, it should be considered when bilateral symmetrical fat accumulation is present because a correct diagnosis has a decisive impact on treatment strategy.  \n1 | Introduction  \nMadelung disease, or benign symmetrical lipomatosis, is characterized by the abnormal growth of non-encapsulated adipose tissue. It can be misdiagnosed as a malignancy or other degenerative disease of adipose tissue [1] . Madelung disease is uncommon by itself, and its manifestation in the scrotal region is exceptionally rare, with only nine cases reported in the literature [2, 3] . We report a case of Madelung disease, which was referred to us upon diagnosis of liposarcoma, but systemic evaluation significantly affected the treatment strategy.  \n2 | Case Presentation  \nA 56-year-old man presented with a 10-month history of painless lower abdominal and scrotal swelling, accompanied by dysuria. The patient was referred to our department with a diagnosis of well differentiated liposarcoma, with no specific  \nmedical or medication history. He had smoked 20 cigarettes per day for 30 years and consumed approximately 20–30 g of alcohol per day. The scrotal mass was notably large, completely burying the penis and displacing both testes cranially, although both were palpable. Magnetic resonance imaging revealed a high signal intensity on both T2-and T1-weighted images, low signal intensity on diffusion-weighted images, and no decrease in the apparent diffusion coefficient map. Fat-suppressed T2-weighted images showed a predominantly low signal intensity, with some areas of the fatty mass exhibiting an internal septal-like structure and heterogeneous contrast enhancement (Figure 1A,B) . Systemic physical examination revealed a body mass index of 21.6 and symmetrical elastic masses in the lower abdomen, scrotum, posterior neck, elbow, mandible, and axillary regions, which was confirmed by computed tomography scan (Figure 1C) . Blood tests showed a mild elevation of enzymes related to liver function. The differential diagnosis included well differentiated liposarcoma and atypical lipomatous tumors. However, the presence of multiple symmetric  \nThis is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-comme","cbCaidH4wHw7q70G","https://ap.wps.com/l/cbCaidH4wHw7q70G","pdf",758023,"English","# Introduction\n# Case Presentation\n# Conclusion\n# Keynote Message","[{\"question\":\"What is Madelung disease, and why is it clinically important in the scrotal region?\",\"answer\":\"Madelung disease is characterized by symmetrical fat accumulation, classically around the neck, shoulders, and trunk. Scrotal involvement is exceptionally rare, and correct diagnosis is crucial because it decisively changes the treatment strategy.\"},{\"question\":\"How did imaging and initial diagnosis differ in this case?\",\"answer\":\"Magnetic resonance imaging suggested a well-differentiated liposarcoma, but whole-body computed tomography showed symmetrical fat accumulation in the upper trunk. Biopsy then confirmed a benign lipoma rather than malignancy.\"},{\"question\":\"What treatment was performed and what was the outcome?\",\"answer\":\"Surgical excision removed a 664 g lipoma from the scrotum and lower abdomen. After surgery, the penile burying was corrected and dysuria improved, allowing the patient to urinate in a standing position.\"}]","Madelung Disease of the Scrotal Region - A Case Report | PDF",1790663702]