[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-detail-31615":3,"doc-seo-31615":27},{"code":4,"msg":5,"data":6},0,"success",{"doc_id":7,"user_id":8,"nickname":9,"user_avatar":10,"doc_module":4,"category_id":11,"category_name":12,"doc_title":13,"doc_description":14,"file_id":15,"file_url":16,"file_type":17,"file_size":18,"view_count":4,"is_deleted":4,"is_public":19,"is_downloadable":19,"audit_status":19,"page_count":20,"language":21,"language_code":22,"table_of_contents":23,"faqs":24,"seo_title":13,"seo_description":14,"update_tm":25,"read_time":26},31615,687197100911,"Himbo","https://ap-avatar.wpscdn.com/avatar/a000239b6f1da00475?_k=1775820430993990792",7,"Healthcare","Macrophages as a Therapeutic Target to Promote Diabetic Wound Healing","Macrophages are central regulators of wound healing due to their stage-dependent plasticity, shifting from pro-inflammatory M1-like states to pro-healing M2-like states. Dysregulated macrophage responses contribute to impaired healing in diabetic wounds, motivating macrophages as a therapeutic target. This review summarizes macrophage roles in normal skin repair, aberrations under diabetic conditions, and recent macrophage-based interventions, including ex vivo activated delivery and pharmacological strategies to eliminate or re-educate local macrophages.","cbCaibrUASJCQUfU","https://ap.wps.com/l/cbCaibrUASJCQUfU","pdf",5017115,1,24,"English","en","# Overview of wound repair\n## Phases of skin healing\n## Macrophage roles and M1/M2 polarization\n## Evidence from macrophage depletion studies\n## Therapeutic targeting in diabetic wounds","[{\"question\":\"Why are macrophages considered key regulators of wound healing?\",\"answer\":\"Macrophages coordinate multiple healing steps by adapting their phenotype according to spatiotemporal cues, shifting from pro-inflammatory M1-like states to pro-healing M2-like states depending on the stage.\"},{\"question\":\"What goes wrong with macrophages in diabetic wound conditions?\",\"answer\":\"Diabetic conditions are associated with dysregulated macrophage responses, which correlates with impaired healing of diabetic wounds.\"},{\"question\":\"What therapeutic strategies are discussed to target macrophages for diabetic wound healing?\",\"answer\":\"The review covers macrophage-based approaches such as delivery of ex vivo activated macrophages and pharmacological strategies aimed at eliminating or re-educating local skin macrophages, including gene-silencing approaches to repolarize toward the M2 phenotype.\"}]",1779829229,60,{"code":4,"msg":28,"data":29},"ok",{"site_id":30,"language":22,"slug":31,"title":13,"keywords":32,"description":14,"schema_data":33,"social_meta":84,"head_meta":86,"extra_data":88,"updated_unix":25},105,"macrophages-as-a-therapeutic-target-to-promote-diabetic-wound-healing","",{"@graph":34,"@context":83},[35,52,66],{"@type":36,"itemListElement":37},"BreadcrumbList",[38,42,46,49],{"item":39,"name":40,"@type":41,"position":19},"https://docshare.wps.com","Home","ListItem",{"item":43,"name":44,"@type":41,"position":45},"https://docshare.wps.com/document/","Document",2,{"item":47,"name":12,"@type":41,"position":48},"https://docshare.wps.com/document/healthcare/",3,{"item":50,"name":13,"@type":41,"position":51},"https://docshare.wps.com/document/macrophages-as-a-therapeutic-target-to-promote-diabetic-wound-healing/31615/",4,{"url":50,"name":13,"@type":53,"author":54,"headline":13,"publisher":56,"fileFormat":59,"description":14,"dateModified":60,"datePublished":60,"encodingFormat":59,"isAccessibleForFree":61,"interactionStatistic":62},"DigitalDocument",{"name":9,"@type":55},"Person",{"url":39,"name":57,"@type":58},"DocShare","Organization","application/pdf","2026-05-26",true,{"@type":63,"interactionType":64,"userInteractionCount":4},"InteractionCounter",{"@type":65},"ViewAction",{"@type":67,"mainEntity":68},"FAQPage",[69,75,79],{"name":70,"@type":71,"acceptedAnswer":72},"Why are macrophages considered key regulators of wound healing?","Question",{"text":73,"@type":74},"Macrophages coordinate multiple healing steps by adapting their phenotype according to spatiotemporal cues, shifting from pro-inflammatory M1-like states to pro-healing M2-like states depending on the stage.","Answer",{"name":76,"@type":71,"acceptedAnswer":77},"What goes wrong with macrophages in diabetic wound conditions?",{"text":78,"@type":74},"Diabetic conditions are associated with dysregulated macrophage responses, which correlates with impaired healing of diabetic wounds.",{"name":80,"@type":71,"acceptedAnswer":81},"What therapeutic strategies are discussed to target macrophages for diabetic wound healing?",{"text":82,"@type":74},"The review covers macrophage-based approaches such as delivery of ex vivo activated macrophages and pharmacological strategies aimed at eliminating or re-educating local skin macrophages, including gene-silencing approaches to repolarize toward the M2 phenotype.","https://schema.org",{"og:url":50,"og:type":85,"og:title":13,"og:site_name":57,"og:description":14},"article",{"robots":87,"canonical":50},"index,follow",{"doc_id":7,"site_id":30}]