[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-381374-105":59,"doc-detail-381374-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","macrophage-based-therapeutic-strategies-in-hematologic-malignancies","Macrophage-Based Therapeutic Strategies in Hematologic Malignancies","","Macrophages exhibit context-dependent, dual roles in tumor growth, with tumor-associated macrophages (TAMs) acting as a diverse immunosuppressive myeloid population across multiple malignancies. TAM infiltration correlates with poor prognosis and reduced treatment responsiveness, including limited effects of checkpoint inhibitors. Clarifying the mechanisms by which macrophages support tumor progression is an active research direction, enabling targeted therapeutic strategies. This review examines anti-TAM approaches, including elimination, reprogramming, and targeting mediators, with emphasis on reversing resistance and modulating anti-tumor immunity, particularly in hematologic tumors.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/macrophage-based-therapeutic-strategies-in-hematologic-malignancies/381374/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/macrophage-based-therapeutic-strategies-in-hematologic-malignancies/381374.png","ImageObject",300,407,{"name":92,"@type":93},"Maya Linwood","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-27","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":14},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What roles do tumor-associated macrophages (TAMs) play in cancer?","Question",{"text":112,"@type":113},"TAMs function as immunosuppressive myeloid cells that significantly influence tumor progression and multiple malignancies. Their presence is linked to poor prognosis and limited treatment response.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How is TAM infiltration related to treatment outcomes?",{"text":117,"@type":113},"TAM infiltration in malignancies is associated with poor prognosis and reduced responsiveness to therapies, including checkpoint inhibitors.",{"name":119,"@type":110,"acceptedAnswer":120},"What therapeutic strategies are reviewed to target TAMs?",{"text":121,"@type":113},"The review focuses on anti-TAM approaches such as eliminating TAMs, rewiring (reprogramming) their functions, or targeting functional mediators released by these cells, with attention to hematologic tumors.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},381374,1790485472,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":14,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},962084928432,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","cancers   \nReview  \nMacrophage-Based Therapeutic Strategies in  \nHematologic Malignancies  \nSaeed Khalili 1, Fatemeh Zeinali 2, Atousa Moghadam Fard 3, Seyed Reza Taha 4,  \nAndarz Fazlollahpour Naghibi 5, Kimia Bagheri 5, Mahdieh Shariat Zadeh 4, Yeghaneh Eslami 6, Khashayar Fattah 7, Naghmeh Asadimanesh 7, Armin Azarimatin 8, Bahman Khalesi 9, Faezeh Almasi 10, * and Zahra Payandeh 11, *  \nCitation: Khalili, S.; Zeinali, F.; Moghadam Fard, A.; Taha, S.R.; Fazlollahpour Naghibi, A.; Bagheri, K.; Shariat Zadeh, M.; Eslami, Y.; Fattah, K.; Asadimanesh, N.; et al. Macrophage-Based Therapeutic Strategies in Hematologic Malignancies. Cancers 2023, 15, 3722 . [https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)cancers15143722  \nAcademic Editor: Zahid Pranjol  \nReceived: 8 June 2023  \nRevised: 15 July 2023  \nAccepted: 19 July 2023  \nPublished: 22 July 2023  \nCopyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Department of Biology Sciences, Shahid Rajaee Teacher Training University, Tehran 1678815811, Iran; [s.khalili88@gmail.com](s.khalili88@gmail.com)  \n2 Department of Immunology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz 6135715794, Iran; [zeinali_fatemeh1998@yahoo.com](zeinali_fatemeh1998@yahoo.com)  \n3 Universal Scientific Education and Research Network (USERN), Tehran 4188783417, Iran; [atoosa.mf74@gmail.com](atoosa.mf74@gmail.com)  \n4 Oncopathology Research Center, Iran University of Medical Sciences, Tehran 1449614535, Iran; [reza.taha.rt7@gmail.com](reza.taha.rt7@gmail.com) (S.R.T.); [mahdiehshariatzadeh@gmail.com](mahdiehshariatzadeh@gmail.com) (M.S.Z.)  \n5 Infectious Diseases and Tropical Medicine Research Center, Health Research Institute, Babol University of  \nMedical Sciences, Babol 4717641367, Iran; [andarz.fpr@gmail.com](andarz.fpr@gmail.com) (A.F.N.); [bagheriikimia@gmail.com](bagheriikimia@gmail.com) (K.B.)  \n6 Faculty of Medicine, Mazandaran University of Medical Sciences, Sari 4815733971, Iran; [yeganeslami99@gmail.com](yeganeslami99@gmail.com)  \n7 School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran 1985717411, Iran; [khashayarfatah@gmail.com](khashayarfatah@gmail.com) (K.F.); [naghmeh_manesh@yahoo.com](naghmeh_manesh@yahoo.com) (N.A.)  \n8 Department of Veterinary Medicine, Shabestar Branch, Islamic Azad University, Shabestar 5381637181, Iran; [azarimatinarmin@yahoo.com](azarimatinarmin@yahoo.com)  \n9 Department of Research and Production of Poultry Viral Vaccine, Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization, Karaj 3197619751, Iran; [khalesi20022002@yahoo.com](khalesi20022002@yahoo.com)  \n10 Pharmaceutical Biotechnology Lab, Department of Microbial Biotechnology, School of Biology and Center of Excellence in Phylogeny of Living Organisms, College of Science, University of Tehran, Tehran 1416634793, Iran  \n11 Department of Molecular Biosciences, Wenner-Gren Institute, Stockholm University, SE 106 91 Stockholm, Sweden  \n* Correspondence: [faezehalmasi@yahoo.com](faezehalmasi@yahoo.com) (F.A.); [zahra.payandeh@su.se](zahra.payandeh@su.se) (Z.P.)  \nSimple Summary: Tumor-associated macrophages (TAMs) are the most prevalent immunosuppressive myeloid cells in the tumor microenvironment, playing significant functions in the regulation of tumor progression, invasion, and metastatic processes. The M1 and M2-polarized phenotypes of TAMs (immunostimulatory and immunosuppressive myeloid cells, respectively) have been potentially implicated in various cancers and autoimmune diseases. Understanding the precise function of TAMs could improve the assessment of the cancer response to T c","cbCaigLHuxsCcJdh","https://ap.wps.com/l/cbCaigLHuxsCcJdh","pdf",1694436,38,"English","# Introduction\n# Tumor-Associated Macrophages (TAMs): Biology and Phenotypes\n## M1 and M2 Polarization\n# Therapeutic Targeting Strategies\n## TAM Depletion Approaches\n## TAM Reprogramming Approaches\n## Targeting TAM-Derived Mediators\n# Emphasis on Hematologic Malignancies\n## Roles in Disease Progression and Treatment Resistance","[{\"question\":\"What roles do tumor-associated macrophages (TAMs) play in cancer?\",\"answer\":\"TAMs function as immunosuppressive myeloid cells that significantly influence tumor progression and multiple malignancies. Their presence is linked to poor prognosis and limited treatment response.\"},{\"question\":\"How is TAM infiltration related to treatment outcomes?\",\"answer\":\"TAM infiltration in malignancies is associated with poor prognosis and reduced responsiveness to therapies, including checkpoint inhibitors.\"},{\"question\":\"What therapeutic strategies are reviewed to target TAMs?\",\"answer\":\"The review focuses on anti-TAM approaches such as eliminating TAMs, rewiring (reprogramming) their functions, or targeting functional mediators released by these cells, with attention to hematologic tumors.\"}]","Macrophage-Based Therapeutic Strategies in Hematologic Malignancies | PDF",1790245060,96]