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De-identified data from the HABS-HD cohort include 84 older adults. Frailty, lower-extremity motor measures, and PET florbetaben uptake (SUVr) were used to derive MRIx via unsupervised dimensionality reduction; correlations tested MRIx and nigral free-water relationships. Lower MRIx linked to higher posterior nigral free water, which correlated with global amyloid signal, while anterior nigra showed no significant effects.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/machine-learningbased-motor-reserve-index-and-nigral-free-water-in-older-adults-abstract/427507/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/machine-learningbased-motor-reserve-index-and-nigral-free-water-in-older-adults-abstract/427507.png","ImageObject",300,407,{"name":92,"@type":93},"Rowan","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-06","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":19},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the Motor Reserve Index (MRIx) and what does it include?","Question",{"text":112,"@type":113},"MRIx is a machine learning–derived index integrating a comorbidity-based frailty measure, gait parameters, balance measures, and sex.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were nigral free water and amyloid burden assessed in the study?",{"text":117,"@type":113},"Free water was measured in the anterior and posterior substantia nigra, and amyloid burden was evaluated using PET florbetaben (FBB) SUVR.",{"name":119,"@type":110,"acceptedAnswer":120},"What associations were found between MRIx, posterior nigral free water, and amyloid signal?",{"text":121,"@type":113},"Participants with lower MRIx showed higher posterior nigral free water, and posterior nigral free water was positively related to global FBB SUVR.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},427507,1791118030,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":19,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":8,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":81},1099514067415,"https://ap-avatar.wpscdn.com/avatar/100002539d78ffe74a7?x-image-process=image/resize,m_fixed,w_180,h_180&k=1779092875211072502","Innovation in Aging, 2025, Vol. 9, No. S2 851  \nAbstract citation ID: igaf122.2883  \nMACHINE LEARNING–BASED MOTOR RESERVE  \nINDEX AND NIGRAL FREE WATER IN OLDER ADULTS  \nEdward Ofori1, Alexander Belnavis1, Roxana Burciu2, and Sydney Schaefer3, 1. Arizona State University, Phoenix, Arizona, United States, 2. University of Delaware, Newark, Delaware, United States, 3. Arizona State University, Tempe, Arizona, United States  \nObjective To develop and test a machine learning–based, Motor Reserve Index (MRIx), integrating a comorbidity-based frailty measure, gait parameters, balance measures, and sex, and to evaluate its associations with free water in the anterior/posterior substantia nigra and amyloid burden. Methods De-identified data from the Health and Aging Brain Study: Health Disparities (HABS-HD) wer∼e collected from 84 older  \nadults (mean age = 60.6 ± 9.5 years; 60% female). Frailty was determined via sum of chronic conditions (e.g., hypertension, cancer, diabetes, stroke, and kidney disease) . Lower extremity motor measures included mean gait speed and inter-trial variability, timed up and go trial variability, Short Physical Performance Battery performance and PET SUVr (florbetaben uptake; PET-FBB) were also computed. An unsupervised dimensionality-reduction method yielded the MRIx from these features. Pearson correlations were used to test MRIx against nigral free-water measures, followed by correlations of anterior and posterior nigral free-water with PET FBB. Significance was set at p \u003C 0.05. Results Participants with lower MRIx (suggesting diminished motor reserve) exhibited higher posterior nigral values (r = −0.29, p \u003C 0.05). Additionally, posterior nigra free-water was positively related to Global FBB SUVR (r≈0.26, p≈0.02), indicating that elevated posterior nigral free water corresponded with greater amyloid signal. Anterior nigra showed no significant associations with MRIx or PET FBB SUVRs. Conclusion These preliminary data indicate that a machine learning–derived Motor Reserve Index, reflecting multiple factors including frailty and gait, may offer insights into posterior nigral changes and amyloid pathology in older adults.","cbCaiv07YorbA4RY","https://ap.wps.com/l/cbCaiv07YorbA4RY","pdf",768033,"English","# Objective\n# Methods\n# Results\n# Conclusion","[{\"question\":\"What is the Motor Reserve Index (MRIx) and what does it include?\",\"answer\":\"MRIx is a machine learning–derived index integrating a comorbidity-based frailty measure, gait parameters, balance measures, and sex.\"},{\"question\":\"How were nigral free water and amyloid burden assessed in the study?\",\"answer\":\"Free water was measured in the anterior and posterior substantia nigra, and amyloid burden was evaluated using PET florbetaben (FBB) SUVR.\"},{\"question\":\"What associations were found between MRIx, posterior nigral free water, and amyloid signal?\",\"answer\":\"Participants with lower MRIx showed higher posterior nigral free water, and posterior nigral free water was positively related to global FBB SUVR.\"}]","MACHINE LEARNING–BASED MOTOR RESERVE INDEX AND NIGRAL FREE WATER IN OLDER ADULTS - Abstract | PDF",1790644039]