[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-detail-121268-en":3,"doc-seo-121268-105":30,"detail-sidebar-cat-0-en-105":92},{"code":4,"msg":5,"data":6},0,"success",{"doc_id":7,"user_id":8,"nickname":9,"user_avatar":10,"doc_module":4,"category_id":11,"category_name":12,"doc_title":13,"doc_description":14,"doc_content":15,"file_id":16,"file_url":17,"file_type":18,"file_size":19,"view_count":20,"is_deleted":4,"is_public":20,"is_downloadable":20,"audit_status":20,"page_count":21,"language":22,"language_code":23,"site_id":24,"html_lang":23,"table_of_contents":25,"faqs":26,"seo_title":27,"seo_description":14,"update_tm":28,"read_time":29},121268,1374391975076,"Riley","https://ap-avatar.wpscdn.com/avatar/14000253ca4ec9f6853?x-image-process=image/resize,m_fixed,w_180,h_180&k=1783305029341752051",8,"Research & Report","Machine learning prediction of tau-PET in Alzheimer’s disease using plasma, MRI, and clinical data","Tau positron emission tomography (PET) provides a reliable measure of regional tau pathology, yet routine clinical adoption is constrained by cost and access. This research evaluates machine learning models that predict clinically useful tau-PET composites, including load and laterality index, from low-cost, non-invasive inputs such as clinical variables, plasma biomarkers, and structural MRI. Findings assess which feature sets and models most accurately approximate tau-PET outcomes for practical use.","UCSF  \nUC San Francisco Previously Published Works  \nTitle  \nMachine learning prediction of tau-PET in Alzheimers disease using plasma, MRI, and clinical data.  \nPermalink  \n[https://escholarship.org/uc/item/1gh5m4sm](https://escholarship.org/uc/item/1gh5m4sm)  \nJournal  \nAlzheimers and Dementia, 21(2)  \nAuthors  \nKarlsson, Linda  \nVogel, Jacob Arvidsson, Ida et al.  \nPublication Date  \n2025-02-01  \nDOI  \n10.1002/alz.14600  \nPeer reviewed  \n[eScholarship.org](eScholarship.org) Powered by the California Digital Library  \nUniversity of California  \nDOI: 10.1002/alz.14600  \nRESEARCH ARTICLE  \nMachine learning prediction of tau-PET in Alzheimer’s disease using plasma, MRI, and clinical data  \nLinda Karlsson1  Olof Strandberg1  \n Jacob Vogel2  Ida Arvidsson3  Kalle Åström3   \n Jakob Seidlitz4, 5, 6, 7  Richard A. I. Bethlehem8  Erik Stomrud1, 9  \nRik Ossenkoppele1, 10 Kaj Blennow11, 13, 18, 19  \nNicholas J. Ashton11, 12 Sebastian Palmqvist1, 9  \nHenrik Zetterberg11, 13, 14, 15, 16, 17   \nRuben Smith1, 9  Shorena Janelidze1  \nRenaud LaJoie20  Gil D. Rabinovici20, 21  Alexa Pichet Binette1 Niklas Mattsson-Carlgren1, 9  Oskar Hansson1  \n1 Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Lund, Sweden  \n2 Department of Clinical Sciences, SciLifeLab, Lund University, Lund, Sweden  \n3 Centre for Mathematical Sciences, Lund University, Lund, Sweden  \n4 Penn/CHOP Lifespan Brain Institute, University of Pennsylvania, Philadelphia, Pennsylvania, USA  \n5 Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA  \n6 Department of Child and Adolescent Psychiatry and Behavioral Science, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA  \n7 Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania, USA  \n8 University of Cambridge, Department of Psychology, Cambridge Biomedical Campus, Cambridge, UK  \n9 Memory Clinic, Skåne University Hospital, Malmö, Sweden  \n10Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Amsterdam UMC, Amsterdam, the Netherlands  \n11 Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden  \n12 Institute of Psychiatry, Psychology and Neuroscience, Maurice Wohl Institute Clinical Neuroscience, King’s College London, London, UK  \n13 Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden  \n14 Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, UK  \n15 UK Dementia Research Institute at UCL, London, UK  \n16 Hong Kong Center for Neurodegenerative Diseases, 5/F, Building 5E, 5 Science Park East Avenue, Hong Kong Science Park, ClearWater Bay, Hong Kong, China  \n17Wisconsin Alzheimer’s Disease Research Center, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA  \n18 Paris Brain Institute, ICM, Pitié-Salpêtrière Hospital, Sorbonne University, Paris, France  \n19 Neurodegenerative Disorder Research Center, Division of Life Sciences and Medicine, and Department of Neurology, Institute on Aging and Brain Disorders, University of Science and Technology of China and First Affiliated Hospital of USTC, Hefei, Anhui, P.R. China  \n20 Department of Neurology, Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, California, USA  \n21 Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA  \nCorrespondence  \nLinda Karlsson and Oskar Hansson, Clinical Memory Research Unit, Department of Clinical Sciences Malmö, BMC C11, Lund University, Box 117, SE-22100 Lund, Sweden. Email: [linda.karlsson@med.lu.se and](linda.karlsson@med.lu.se and)[ ](linda.karlsson@med.lu.se and)[oskar.hansson@med.lu.se](oskar.hansson@med.lu.se)  \nAbstract  \nINTRODUCTION: Tau","cbCaibShCK0anCan","https://ap.wps.com/l/cbCaibShCK0anCan","pdf",3913888,1,17,"English","en",105,"# Introduction\n## Methods\n## Results\n## Funding and publication information","[{\"question\":\"Why is tau-PET limited in routine clinical use?\",\"answer\":\"Tau-PET is reliable for assessing tau pathology, but cost and accessibility barriers limit its routine clinical use.\"},{\"question\":\"What inputs do the machine learning models use to predict tau-PET composites?\",\"answer\":\"Models predict tau-PET composites using low-cost, non-invasive features such as clinical variables, plasma biomarkers, and structural MRI.\"},{\"question\":\"Which feature set is reported to improve prediction accuracy?\",\"answer\":\"Models that include plasma biomarkers are reported to yield the most accurate predictions.\"}]","Machine learning prediction of tau-PET in Alzheimer’s disease using plasma, MRI, and clinical data | PDF",1785734793,43,{"code":4,"msg":31,"data":32},"ok",{"site_id":24,"language":23,"slug":33,"title":13,"keywords":34,"description":14,"schema_data":35,"social_meta":87,"head_meta":89,"extra_data":91,"updated_unix":28},"machine-learning-prediction-of-tau-pet-in-alzheimers-disease-using-plasma-mri-and-clinical-data","",{"@graph":36,"@context":86},[37,54,69],{"@type":38,"itemListElement":39},"BreadcrumbList",[40,44,48,51],{"item":41,"name":42,"@type":43,"position":20},"https://docshare.wps.com","Home","ListItem",{"item":45,"name":46,"@type":43,"position":47},"https://docshare.wps.com/document/","Document",2,{"item":49,"name":12,"@type":43,"position":50},"https://docshare.wps.com/document/research-report/",3,{"item":52,"name":13,"@type":43,"position":53},"https://docshare.wps.com/document/machine-learning-prediction-of-tau-pet-in-alzheimers-disease-using-plasma-mri-and-clinical-data/121268/",4,{"url":52,"name":13,"@type":55,"author":56,"headline":13,"publisher":58,"fileFormat":61,"inLanguage":23,"description":14,"dateModified":62,"datePublished":63,"encodingFormat":61,"isAccessibleForFree":64,"interactionStatistic":65},"DigitalDocument",{"name":9,"@type":57},"Person",{"url":41,"name":59,"@type":60},"DocShare","Organization","application/pdf","2026-08-04","2026-08-03",true,{"@type":66,"interactionType":67,"userInteractionCount":20},"InteractionCounter",{"@type":68},"ViewAction",{"@type":70,"mainEntity":71},"FAQPage",[72,78,82],{"name":73,"@type":74,"acceptedAnswer":75},"Why is tau-PET limited in routine clinical use?","Question",{"text":76,"@type":77},"Tau-PET is reliable for assessing tau pathology, but cost and accessibility barriers limit its routine clinical use.","Answer",{"name":79,"@type":74,"acceptedAnswer":80},"What inputs do the machine learning models use to predict tau-PET composites?",{"text":81,"@type":77},"Models predict tau-PET composites using low-cost, non-invasive features such as clinical variables, plasma biomarkers, and structural MRI.",{"name":83,"@type":74,"acceptedAnswer":84},"Which feature set is reported to improve prediction accuracy?",{"text":85,"@type":77},"Models that include plasma biomarkers are reported to yield the most accurate predictions.","https://schema.org",{"og:url":52,"og:type":88,"og:title":13,"og:site_name":59,"og:description":14},"article",{"robots":90,"canonical":52},"index,follow",{"doc_id":7,"site_id":24},{"code":4,"msg":5,"data":93},[94,98,102,106,111,116,121,124,129,132,136],{"id":20,"doc_module":4,"doc_module_name":46,"category_name":95,"show_sort_weight":96,"slug":97},"Story & Novel",90,"story-novel",{"id":47,"doc_module":4,"doc_module_name":46,"category_name":99,"show_sort_weight":100,"slug":101},"Literature",80,"literature",{"id":53,"doc_module":4,"doc_module_name":46,"category_name":103,"show_sort_weight":104,"slug":105},"Exam",70,"exam",{"id":107,"doc_module":4,"doc_module_name":46,"category_name":108,"show_sort_weight":109,"slug":110},5,"Comic",60,"comic",{"id":112,"doc_module":4,"doc_module_name":46,"category_name":113,"show_sort_weight":114,"slug":115},6,"Technology",50,"technology",{"id":117,"doc_module":4,"doc_module_name":46,"category_name":118,"show_sort_weight":119,"slug":120},7,"Healthcare",40,"healthcare",{"id":11,"doc_module":4,"doc_module_name":46,"category_name":12,"show_sort_weight":122,"slug":123},30,"research-report",{"id":125,"doc_module":4,"doc_module_name":46,"category_name":126,"show_sort_weight":127,"slug":128},9,"Religion & Spirituality",20,"religion-spirituality",{"id":127,"doc_module":4,"doc_module_name":46,"category_name":130,"show_sort_weight":127,"slug":131},"World Cup","world-cup",{"id":133,"doc_module":4,"doc_module_name":46,"category_name":134,"show_sort_weight":133,"slug":135},10,"Lifestyle","lifestyle",{"id":137,"doc_module":4,"doc_module_name":46,"category_name":138,"show_sort_weight":107,"slug":139},19,"General","general"]