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Results show EGFR-mutant cases have higher METTL3 and ALKBH5 expression, with high levels independently linked to shorter progression-free survival.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/m6a-methylation-regulators-mettl3-and-alkbh5-are-risk-factors-for-egfr-mutant-nsclc-article-abstract/370537/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/m6a-methylation-regulators-mettl3-and-alkbh5-are-risk-factors-for-egfr-mutant-nsclc-article-abstract/370537.png","ImageObject",300,407,{"name":42,"@type":43},"Maya Linwood","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-29","2026-09-23",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",6,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What is the main question of the study?","Question",{"text":63,"@type":64},"The study examines whether m6A-related proteins, especially METTL3 and ALKBH5, are associated with EGFR mutations in NSCLC and what clinical significance they have.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How were m6A-related regulators assessed?",{"text":68,"@type":64},"Associations were analyzed using datasets including The Cancer Genome Atlas, case collection and follow-up, together with immunohistochemistry and scoring.",{"name":70,"@type":61,"acceptedAnswer":71},"What did the study find about METTL3 and ALKBH5?",{"text":72,"@type":64},"EGFR-mutant NSCLC specimens showed significantly higher METTL3 and ALKBH5 expression than EGFR-wildtype specimens. High METTL3 and ALKBH5 expression were independent risk factors for progression-free survival.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},370537,1790641380,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,105,109,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":102,"show_sort_weight":103,"slug":104},"Technology",50,"technology",{"id":106,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":107,"slug":108},7,40,"healthcare",{"id":110,"doc_module":4,"doc_module_name":25,"category_name":111,"show_sort_weight":112,"slug":113},8,"Research & Report",30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":106,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":139,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":145},962084928432,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","M6A Methylation Regulators METTL3 and ALKBH5 are Risk Factors for EGFR-Mutant NSCLC  \nCancer Control Volume 32: 1-13 © The Author(s) 2025 Article reuse guidelines:  \n[sagepub.com/journals-permissions](sagepub.com/journals-permissions)[ ](sagepub.com/journals-permissions)[DOI: 10.1177/10732748251342685](DOI: 10.1177/10732748251342685)  \n[journals.sagepub.com/home/ccx](journals.sagepub.com/home/ccx)  \nYaofeng Zhi, MMed 1,* 􀀁, Silin Liu, MMed1,2,* 􀀁, Xuefei Chang, MMed1,2 􀀁 , Wanxian Guan, MMed 1,2 􀀁, Ronggang Li, MMed3 􀀁, Qiongru Liu, BSc3 􀀁 , Jiaqing Chen, MSc 1 􀀁, Jie Ling, BSc1 􀀁, Xulin Zhao, BSc1 􀀁, Aibin Liu, MD4,5 􀀁 , Jiarong Chen, MD 1,6 􀀁, Xin Zhang, MD1,7,8 􀀁, and Yanming Huang, MMed1,3 􀀁  \nAbstract  \nIntroduction: Non-small cell lung cancer (NSCLC), which accounts for >85% of all lung cancers, is the most common solid malignant tumor, with high morbidity and mortality worldwide. Epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) treatment is widely used clinically because the epidermal growth factor receptor (EGFR) is the main driver gene of lung cancer; however, the development of drug resistance is inevitable. Epigenetic abnormalities can also lead to tyrosine kinase inhibitor (TKI) resistance. However, the relationship between N6-methyladenosine (m6A)-related proteins and EGFR mutations in NSCLC and their clinical significance remain unclear. In this retrospective study, the expression of m6A-related regulatory factors in patients with EGFR mutations were analyzed to investigate their relationship with clinicopathological features and prognoses.  \nMethods: The association between m6A-related regulatory factors and NSCLC was analyzed using data derived from The Cancer Genome Atlas, case collection, follow-up, immunohistochemistry, and scoring.  \nResults: A total of 246 NSCLC specimens were examined in this study. Among these, 143 EGFR-mutant cases exhibited significantly higher expression of METTL3 and ALKBH5 compared to EGFR-wildtype specimens. The median progression-free survival time of patients with high METTL3 expression (SI >6) was 25.0 months, and that of patients with high ALKBH5 expression (SI >6) was 24.1 months in EGFR-mutant cases. High METTL3 and ALKBH5 expression levels are independent risk factors for progression-free survival in patients with EGFR mutations. The median progression-free survival time  \n1 Clinical Experimental Center, Jiangmen Engineering Technology Research Center of Clinical Biobank and Translational Research, Jiangmen Key Laboratory of  \nPrecision and Clinical Translation Medicine, Jiangmen Central Hospital, China 2Department of Pulmonary and Critical Care Medicine, Jiangmen Central Hospital, China 3Department of Pathology, Jiangmen Central Hospital, China  \n4Department of Geriatrics, Xiangya Hospital, Central South University, Changsha, China  \n5National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China 6Department of Oncology, Jiangmen Central Hospital, China  \n7Dongguan Key Laboratory of Medical Bioactive Molecular Developmental and Translational Research, Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guangdong Medical University, Dongguan, China  \n8Collaborative Innovation Center for Antitumor Active Substance Research and Development, Guangdong Medical University, Zhanjiang, China  \n*Yaofeng Zhi and Silin Liu contribute equally to this research.  \nCorresponding Authors:  \nXin Zhang, Jiangmen central Hospital, No.23 of Haibang Street, Jiangmen, Guangdong 529030, China.  \nEmail: [zhangx45@mail3.sysu.edu.cn](zhangx45@mail3.sysu.edu.cn)  \nYanming Huang, Jiangmen Central Hospital, No.23 of Haibang Street, Jiangmen, Guangdong 529030, China.  \nEmail: [huangyanming_jxy@163.com](huangyanming_jxy@163.com)  \nCreative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons  \nAttribution-NonCommercial 4.0 License ([https://creativecommons.org/licen","cbCailiNgKS8GhXq","https://ap.wps.com/l/cbCailiNgKS8GhXq","pdf",2754652,13,"English","# Abstract\n## Introduction\n## Methods\n## Results\n## Conclusions","[{\"question\":\"What is the main question of the study?\",\"answer\":\"The study examines whether m6A-related proteins, especially METTL3 and ALKBH5, are associated with EGFR mutations in NSCLC and what clinical significance they have.\"},{\"question\":\"How were m6A-related regulators assessed?\",\"answer\":\"Associations were analyzed using datasets including The Cancer Genome Atlas, case collection and follow-up, together with immunohistochemistry and scoring.\"},{\"question\":\"What did the study find about METTL3 and ALKBH5?\",\"answer\":\"EGFR-mutant NSCLC specimens showed significantly higher METTL3 and ALKBH5 expression than EGFR-wildtype specimens. High METTL3 and ALKBH5 expression were independent risk factors for progression-free survival.\"}]","M6A Methylation Regulators METTL3 and ALKBH5 are Risk Factors for EGFR-Mutant NSCLC - Article abstract | PDF",1790189043,33]