[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-508655-105":59,"doc-detail-508655-en":134},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":127,"head_meta":129,"extra_data":131,"updated_unix":133},105,"en","lynch-syndrome-number-147-november-2014","Lynch Syndrome - Number 147 - November 2014","","Lynch syndrome, an autosomal dominant inherited cancer susceptibility syndrome, results from defects in the DNA mismatch repair system that fails to correct single-base mismatches during DNA replication. Beyond colorectal cancer, it is strongly associated with endometrial and ovarian cancers and a broader tumor spectrum, including gastric, small bowel, hepatobiliary, and urinary tract cancers, among others. Clinicians can identify at-risk individuals using personal and family histories, genetic counseling, and testing, while molecular tumor abnormalities may also reveal the syndrome even without informative family history. The document outlines key background and epidemiologic risks affecting prevention and screening decisions.",{"@graph":69,"@context":126},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/lynch-syndrome-number-147-november-2014/508655/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/lynch-syndrome-number-147-november-2014/508655.png","ImageObject",300,407,{"name":92,"@type":93},"kopisore","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-22","2026-10-05",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118,122],{"name":109,"@type":110,"acceptedAnswer":111},"Lynch syndrome是什么，它由什么导致？","Question",{"text":112,"@type":113},"Lynch syndrome是一种常染色体显性遗传的肿瘤易感综合征，源于DNA错配修复系统的缺陷，无法纠正DNA复制过程中出现的单碱基错配，从而增加多种癌症风险。","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"妇科医生为什么处在识别Lynch syndrome高风险女性的独特位置？",{"text":117,"@type":113},"由于Lynch syndrome中最常见的癌症类型之一发生在女性生殖道，妇科及相关专科医生能够基于个人与家族病史进行评估，并在必要时通过遗传咨询与检测识别高风险女性。",{"name":119,"@type":110,"acceptedAnswer":120},"Lynch syndrome的主要癌症风险有哪些，风险如何随年龄估计？",{"text":121,"@type":113},"基于现有数据，Lynch syndrome患者到70岁时的结直肠癌风险约为18–61%，子宫内膜癌风险约为16–61%且可能等于或高于结直肠癌风险，卵巢癌风险约为5–10%。",{"name":123,"@type":110,"acceptedAnswer":124},"不同错配修复基因突变会如何影响癌症风险？",{"text":125,"@type":113},"风险会随错配修复基因突变类型而变化，例如MLH1携带者到70岁时子宫内膜癌风险约为20–54%，MSH2携带者约为21–49%，MSH6携带者子宫内膜癌累积风险约为16–61%，且发病平均年龄更晚。","https://schema.org",{"og:url":83,"og:type":128,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":130,"canonical":83},"index,follow",{"doc_id":132,"site_id":62},508655,1791688099,{"code":4,"msg":5,"data":135},{"doc_id":132,"user_id":136,"nickname":92,"user_avatar":137,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":138,"file_id":139,"file_url":140,"file_type":141,"file_size":142,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":143,"language":144,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":145,"faqs":146,"seo_title":147,"seo_description":67,"update_tm":148,"read_time":149,"preview_page_count":4},962090880963,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","The American College of Obstetricians and Gynecologists WOMEN’S HEALTH CARE PHYSICIANS  \nPRACTICE BULLETIN  \nclinical management guidelines for obstetrician–gynecologists  \nNumber 147, November 2014  \nLynch Syndrome  \nLynch syndrome, previously known as hereditary nonpolyposis colorectal cancer, is an autosomal dominant inherited cancer susceptibility syndrome caused by defects in the mismatch repair system. This system depends on a family of genes that are conserved across most living organisms and is responsible for repairing single-base mismatches that occur during DNA replication. In addition to colorectal cancer, hallmark diseases of Lynch syndrome include endometrial and ovarian cancer. Other tumors within the spectrum of Lynch syndrome include gastric cancer, small bowel cancer, hepatobiliary cancer, renal pelvis and ureter cancer, as well as some types of breast cancer, certain brain tumors, and sebaceous skin tumors (1–4). By identifying individuals at risk of Lynch syndrome through assessment of personal and family medical histories and genetic counseling and testing, when indicated, physicians are able to offer screening and prevention strategies to reduce morbidity and mortality from this syndrome.  \nNotably, the molecular abnormalities present in Lynch syndrome-associated tumors cause specific changes in the tumor tissue that can be detected by laboratory testing and, thus, identify the syndrome even in the absence of an informative family medical history. Because two of the most common types of cancer in Lynch syndrome occur in the female reproductive tract, obstetricians, gynecologists, and gynecologic oncologists are in a unique position to identify women who are at substantial risk of Lynch syndrome. The purpose of this document is to educate and provide an overview of Lynch syndrome because early identification of mutation carriers allows prevention of most Lynch syndrome-associated malignancies (5, 6).  \nBackground  \nDr. Aldred Scott Warthin first reported on a family with a hereditable aggregation of uterine and gastrointestinal neoplasms in 1913 (7) . This kindred, identified as family G, was further expanded by Henry Lynch and colleagues in 1971 and 2005 (8, 9) . At the time of the 2005 report, cancer history was available on 929 descendants spanning seven generations. Lynch, in addition to his  \nwork on family G, also further characterized this syndrome in a series of seminal reports starting in 1966 (10) .  \nApproximately 3–5% of cases of uterine cancer are attributable to a hereditary cause, whereas 8–13% of cases of ovarian cancer are likely inherited (11, 12) . Lynch syndrome accounts for most cases of hereditary uterine and colorectal cancer and is the second most common cause of inherited ovarian cancer (after hereditary breast and ovarian cancer syndrome) (13) . Lynch  \nCommittee on Practice Bulletins—Gynecology and the Society of Gynecologic Oncology. This Practice Bulletin was developed by the American College of Obstetricians and Gynecologists’ Committee on Practice Bulletins—Gynecology and the Society of Gynecologic Oncology’s (SGO) Lynch Working Group on behalf of the SGO Clinical Practice Committee. Member contributors included Lee-may Chen, MD; David E. Cohn, MD; David A. Fishman, MD; Randall K. Gibb, MD; David G. Mutch, MD; Alexander B. Olawaiye, MD; and David E. Soper, MD, with the editorial assistance of Karen H. Lu, MD, and Noah D. Kauff, MD. The information is designed to aid practitioners in making decisions about appropriate obstetric and gynecologic care. These guidelines should not be construed as dictating an exclusive course of treatment or procedure. Variations in practice may be warranted based on the needs of the individual patient, resources, and limitations unique to the institution or type of practice.  \nsyndrome is a highly penetrant autosomal dominant inherited cancer condition characterized by defects in DNA mismatch repair and has a population prevalence of approximatel","cbCaigUPN220KtDZ","https://ap.wps.com/l/cbCaigUPN220KtDZ","pdf",208591,13,"English","# Background\n## Historical discovery and family aggregation\n## Inheritance, prevalence, and associated genes\n## Cancer risk estimates across ages","[{\"question\":\"Lynch syndrome是什么，它由什么导致？\",\"answer\":\"Lynch syndrome是一种常染色体显性遗传的肿瘤易感综合征，源于DNA错配修复系统的缺陷，无法纠正DNA复制过程中出现的单碱基错配，从而增加多种癌症风险。\"},{\"question\":\"妇科医生为什么处在识别Lynch syndrome高风险女性的独特位置？\",\"answer\":\"由于Lynch syndrome中最常见的癌症类型之一发生在女性生殖道，妇科及相关专科医生能够基于个人与家族病史进行评估，并在必要时通过遗传咨询与检测识别高风险女性。\"},{\"question\":\"Lynch syndrome的主要癌症风险有哪些，风险如何随年龄估计？\",\"answer\":\"基于现有数据，Lynch syndrome患者到70岁时的结直肠癌风险约为18–61%，子宫内膜癌风险约为16–61%且可能等于或高于结直肠癌风险，卵巢癌风险约为5–10%。\"},{\"question\":\"不同错配修复基因突变会如何影响癌症风险？\",\"answer\":\"风险会随错配修复基因突变类型而变化，例如MLH1携带者到70岁时子宫内膜癌风险约为20–54%，MSH2携带者约为21–49%，MSH6携带者子宫内膜癌累积风险约为16–61%，且发病平均年龄更晚。\"}]","Lynch Syndrome - Number 147 - November 2014 | PDF",1791231175,33]