[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-419098-105":59,"doc-detail-419098-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","lymph-food-to-improve-canine-atopic-dermatitis-a-randomized-double-blinded-controlled-trial-in-dogs-with-standard-care-treatment","Lymph food to improve canine atopic dermatitis - a randomized, double-blinded, controlled trial in dogs with standard-care treatment","","Micronutritional deficits are linked to increased morbidity and mortality, and canine atopic dermatitis (CAD) may involve iron depletion and subclinical inflammation despite typical meat-based diets, suggesting micronutritional malabsorption. This randomized, double-blinded, 112-day study evaluated whether a complementary lymph food enriched with whey protein, vitamins, minerals, and antioxidants could improve CAD clinical signs and blood parameters. Thirty-eight CAD dogs received either active lymph food or a hydrolyzed placebo, with outcomes assessed using PVAS, CADESI-4, and blood tests.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/lymph-food-to-improve-canine-atopic-dermatitis-a-randomized-double-blinded-controlled-trial-in-dogs-with-standard-care-treatment/419098/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/lymph-food-to-improve-canine-atopic-dermatitis-a-randomized-double-blinded-controlled-trial-in-dogs-with-standard-care-treatment/419098.png","ImageObject",300,407,{"name":92,"@type":93},"Aditya","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",12,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What was the study designed to test regarding canine atopic dermatitis?","Question",{"text":113,"@type":114},"The study tested whether an enriched complementary lymph food could improve CAD clinical signs and blood parameters in dogs receiving standard-care treatment.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How were itch and skin lesion severity measured during the trial?",{"text":118,"@type":114},"Owners recorded pruritus weekly using the Pruritus Visual Analog Scale (PVAS), while veterinarians assessed skin lesions monthly using the CAD Atopic Dermatitis Extent and Severity Index (CADESI-4).",{"name":120,"@type":111,"acceptedAnswer":121},"What outcomes differed between the active lymph food group and the placebo group?",{"text":122,"@type":114},"The active group showed greater reductions in CADESI-4 and PVAS scores, declined medication use, and increased red blood cell counts, packed cell volume, and serum iron compared with placebo.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},419098,1791095824,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146,"preview_page_count":4},962085564549,"https://ap-avatar.wpscdn.com/davatar_085a072bc5b1113ac321206ff7593b45","TYPE Original Research PUBLISHED 19 December 2025 DOI 10. 3389/fvets.2025.1657869  \nOPEN ACCESS  \nEDITED BY  \nRegiane R. Santos,  \nSchothorst Feed Research, Netherlands  \nREVIEWED BY  \nElena Dalle Vedove, CIAM S. r.l, Italy Christopher Thomas,  \nCardiff University, United Kingdom  \n*CORRESPONDENCE  \nFranziska Roth-Walter  \n [franziska. roth-walter@vetmeduni.ac.at](franziska. roth-walter@vetmeduni.ac.at)  \nRECEIVED 11 July 2025  \nREVISED 24 October 2025  \nACCEPTED 24 November 2025  \nPUBLISHED 19 December 2025  \nCITATION  \nFrizzo-Ramos C, Doulidis PG, Burgener IA, Horvath Ungerbck C, Einspieler V, Weiser U, Panakova L and Roth-Walter F (2025) Lymph food to improve canine atopic dermatitis: a randomized, double-blinded, controlled trial in dogs with standard-care treatment.  \nFront. Vet. Sci. 12:1657869 .  \ndoi: 10.3389/fvets.2025.1657869  \nCOPYRIGHT  \n© 2025 Frizzo-Ramos, Doulidis, Burgener, Horvath Ungerbck, Einspieler, Weiser, Panakova and Roth-Walter. This is an  \nopen-access article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nLymph food to improve canine atopic dermatitis: a randomized, double-blinded, controlled trial in dogs with standard-care treatment  \nCarolina Frizzo-Ramos1,2 , Pavlos G. Doulidis2 ,  \nIwan Anton Burgener2 , Christa Horvath Ungerbck2 , Veronika Einspieler2 , Ulrike Weiser2 , Lucia Panakova2 and Franziska Roth-Walter1,3*  \n1 Department of Biological Sciences and Pathobiology, University of Veterinary Medicine Vienna, Vienna, Austria, 2 Department for Companion Animals and Horses, Clinical Unit of Small Animals Internal Medicine, Dermatology, University of Veterinary Medicine Vienna, Vienna, Austria, 3ViaLym FlexCo, Tulln, Austria  \nIntroduction: Micronutritional deficits are linked to increased morbidity and mortality. Canine atopic dermatitis (CAD) often presents with iron depletion and subclinical inflammation, despite their typical meat-based diets, suggesting widespread micronutritional malabsorption. This study aimed to determine if a complementary lymph food—enriched with whey protein, vitamins, minerals, and antioxidants, and designed to bypass mucosal malabsorption barriers—could improve CAD clinical signs and blood parameters.  \nAnimals: Thirty-eight dogs diagnosed with canine atopic dermatitis were included in the study.  \nMethods: In a 112-day, double-blinded, randomized study, 38 CAD dogs daily received 10 g of either the active lymph food (n = 19) or a hydrolyzed food placebo (n = 19) . Owners weekly recorded pruritus using the Pruritus Visual Analog Scale (PVAS) and logged medication use (Janus kinase inhibitors, corticosteroids, antihistamines, cyclosporine, and Lokivetmab) . Veterinarians monthly assessed skin lesions via the Canine Atopic Dermatitis Extent and Severity Index (CADESI-4) . Blood samples were collected at baseline and at the study’s end. Treatment success was defined as a decrease of ≥2 on the PVAS anda ≥50% reduction in CADESI-4 .  \nResults: The complementary lymph food was well-accepted by the dogs. The active feed group showed significantly greater reductions in both CADESI-4 scores (−55%) and PVAS scores (−1.8) compared to the placebo group (+26%, p \u003C 0.0003 and −0 .05%, p = 0.0074, respectively), indicating an added benefit to standard care treatment. Medication use significantly declined in the active group. Furthermore, red blood cell counts, packed cell volume (PCV), and serum iron increased in the active group but not in the placebo group. A threefold significantly greater proportion of dogs in the active group achieved treatment success compared to the placebo group.  \nConclusion: Lymphatic nutrient f","cbCailMm7hIRspfI","https://ap.wps.com/l/cbCailMm7hIRspfI","pdf",5882840,14,"English","# Introduction\n## Background on canine atopic dermatitis\n## Nutrition, micronutrient deficiency, and malabsorption\n# Methods\n## Study design and grouping\n## Outcome measures\n# Results\n## Clinical scoring and symptom changes\n## Medication use and hematologic parameters\n# Conclusion","[{\"question\":\"What was the study designed to test regarding canine atopic dermatitis?\",\"answer\":\"The study tested whether an enriched complementary lymph food could improve CAD clinical signs and blood parameters in dogs receiving standard-care treatment.\"},{\"question\":\"How were itch and skin lesion severity measured during the trial?\",\"answer\":\"Owners recorded pruritus weekly using the Pruritus Visual Analog Scale (PVAS), while veterinarians assessed skin lesions monthly using the CAD Atopic Dermatitis Extent and Severity Index (CADESI-4).\"},{\"question\":\"What outcomes differed between the active lymph food group and the placebo group?\",\"answer\":\"The active group showed greater reductions in CADESI-4 and PVAS scores, declined medication use, and increased red blood cell counts, packed cell volume, and serum iron compared with placebo.\"}]","Lymph food to improve canine atopic dermatitis - a randomized, double-blinded, controlled trial in dogs with standard-care treatment | PDF",1790615609,35]