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This single-arm prospective study evaluated feasibility and efficacy of LDCT screening in a real-life French administrative territory. Participants aged 55–74 and with significant smoking history underwent baseline and subsequent annual rounds, with results assessed across three screening iterations.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/lung-cancer-screening-by-low-dose-ct-scan-in-france-final-results-of-the-dep-kp80-study-after-three-rounds/329656/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/lung-cancer-screening-by-low-dose-ct-scan-in-france-final-results-of-the-dep-kp80-study-after-three-rounds/329656.png","ImageObject",300,407,{"name":92,"@type":93},"Genevieve","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-25","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What was the goal of the DEP KP80 study in France?","Question",{"text":112,"@type":113},"To assess the feasibility and efficacy of lung cancer screening using low-dose CT in a real-life setting within a French administrative territory.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Who were the participants and how was screening delivered?",{"text":117,"@type":113},"Participants aged 55–74, including current or former smokers with at least 30 pack-years, were recruited; annual LDCT scans were scheduled and three rounds were performed.",{"name":119,"@type":110,"acceptedAnswer":120},"What were the main findings after three rounds of screening?",{"text":121,"@type":113},"Among 1254 enrolled participants, baseline uptake was 75.4% and subsequent completion declined. Forty-two lung cancers were diagnosed, most at early stages, and the positive predictive value for a positive screen was 48%.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},329656,1790106420,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},1374391974585,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","Articles   \nLung cancer screening by low-dose CT scan in France: final results of the DEP KP80 study after three rounds  \nOlivier Leleu,a,∗ Nicolas Storme,b Damien Basille,b,c Marianne Auquier,d Valerie Petigny,e Pascal Berna,f Alexia Letierce,g Sebastien Couraud,h Julie de Bermont,h Bernard Milleron,i and Vincent Jounieauxb,c  \naDepartment of Pulmonology and Thoracic Oncology Centre Hospitalier Abbeville, Abbeville Cedex, France bDepartment of Pulmonology and Thoracic Oncology CHU Amiens, Amiens, France  \ncAGIR Unit, University of Picardie Jules Verne, Amiens, France dDepartment of Radiology CHU Amiens, Amiens, France eCRCDC 6 Rue Colbert Amiens, France  \nfDepartment of Thoracic Surgery CHU Amiens, France gBiostatistician, QualityStat, Morangis, France  \nhRespiratory Medicine Department, CHU Lyon Sud, Lyon, France iIntergroupe Francophone de Cancérologie Thoracique, Paris, France  \nSummary  \nBackground In prior randomised controlled trials, lung cancer screening using low-dose computed tomography (LDCT) has been shown to reduce lung cancer mortality and overall mortality. Despite these results, organised screening in France remains a challenge.  \nThis study assessed the feasibility and efficacy of lung cancer screening within a real-life context in a French administrative territory.  \nMethods DEP KP80 was a single-arm prospective study. Participants aged between 55 and 74 years, smokers or former smokers of ≥30 pack-years, were recruited. An annual LDCT scan was scheduled and three rounds were performed. Subjects were selected by general practitioners or pulmonologists, who checked the inclusion criteria and prescribed the CT scan.  \nFindings Between March 2016 and February 2020, 1254 participants were enrolled. Overall, 945 (75.4%) participants underwent baseline LDCT (T0), 376 (42.8%) completed the first round (T1) and 270 (31%) the second (T2) one. Fortytwo lung cancers were diagnosed, 30 cancers (71.4%) were stage I or II and 34 cancers (80.9%) were treated surgically. In this study, the overall positive predictive value for a positive screening was 48%(95% CI 37–59) and the negative predictive value 100%(95% CI 100–100) .  \nInterpretation This study demonstrated the feasibility and efficacy oflung cancer screening in a real-life context with most lung cancers diagnosed at an early stage and surgically removed. Our results also highlighted the importance of participation in each round, underlining the fact that optimising organisation is a major goal.  \nFunding Agence Régionale de Santé de Picardie, La Ligue contre le cancer, le Conseil Départemental de la Somme, and AstraZeneca.  \nCopyright © 2024 The Author(s) . Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license ([http://creativecommons.org/licenses/by-nc-nd/4.0/](http://creativecommons.org/licenses/by-nc-nd/4.0/)).  \nKeywords: Screening; Lung cancer; Early detection; Low-dose computed tomography (LDCT) scan; Real life  \nIntroduction  \nDespite major therapeutic advances in recent years, lung cancer remains the world’s leading cause of cancerrelated death, accounting for almost 2 million deaths every year, which is more than deaths related to breast and colon cancer combined.1 The most powerful  \nprognostic factor in lung cancer is its tumour, node, metastasis (TNM) classification, with 5-year survival rates ranging from 92% for Stage IA to 10% for Stage IVA.2, 3 Unfortunately, lung cancer is usually diagnosed at an advanced stage. The recent French KBP-2020 study showed that, out of 8999 new lung cancer cases, only  \neBioMedicine 2024;109: 105396  \nPublished Online 12 October 2024 [https://doi.org/10](https://doi.org/10) . 1016/j.ebiom.2024 . 105396  \n*Corresponding author.  \nE-mail address: [leleu.olivier@ch-abbeville.fr](leleu.olivier@ch-abbeville.fr) (O. Leleu).  \n[www.thelancet.com Vol](www.thelancet.com Vol) 109 November, 2024 1  \n Articles  \nResearch in context  \nEvidence before this study  \nLung cancer is a major public health prob","cbCaiu32h6loqcdw","https://ap.wps.com/l/cbCaiu32h6loqcdw","pdf",989881,14,"English","# Summary\n## Background\n## Methods\n## Findings\n## Interpretation\n## Funding\n# Research in context\n## Evidence before this study\n## Added value of this study\n## Implications of all the available evidence","[{\"question\":\"What was the goal of the DEP KP80 study in France?\",\"answer\":\"To assess the feasibility and efficacy of lung cancer screening using low-dose CT in a real-life setting within a French administrative territory.\"},{\"question\":\"Who were the participants and how was screening delivered?\",\"answer\":\"Participants aged 55–74, including current or former smokers with at least 30 pack-years, were recruited; annual LDCT scans were scheduled and three rounds were performed.\"},{\"question\":\"What were the main findings after three rounds of screening?\",\"answer\":\"Among 1254 enrolled participants, baseline uptake was 75.4% and subsequent completion declined. Forty-two lung cancers were diagnosed, most at early stages, and the positive predictive value for a positive screen was 48%.\"}]","Lung cancer screening by low-dose CT scan in France - final results of the DEP KP80 study after three rounds | PDF",1789985089,35]