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Authors conceptualized the project, conducted mouse experiments, and performed RNA-seq, mutation curation, and pollution-data integration across multiple cohorts. The work includes analyses of mutational signatures, DNA extraction and sequencing data generation, ddPCR experiments, and pathological assessments, with additional oversight for clinical crossover study profiling and epidemiological inference. 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Author manuscript; available in PMC 2023 June 01.  \nPublished in final edited form as:  \nNature. 2023 April 01; 616(7955): 159–167. doi:10.1038/s41586-023-05874-3 .  \nThis work is licensed under a CC BY 4.0 International license.  \n128Cor127 Thesponding ause authors joithntolry:sCharlesupervise. Swdtanhiston@workc:ricEkm.acilia.ukL.. Lim, James DeGregori, Mariam Jamal-Hanjani.  \n*A list of authors and their affiliations appears at the end of the paper.  \nAuthor contributions  \nW.H. and E.L.L jointly conceptualized the project, designed the project, performed the experiments analyses and wrote the manuscript. W.H. led and performed the mouse experiments, and E.L.L. led and performed the bioinformatics and epidemiology analyses. C.E.W. performed the mouse experiments, helped write the manuscript and curated the mutation literature. C.L. performed the human RNA-seq analyses and curated the pollution data. M.A. performed the UKBB analyses. K.C. assembled and analysed the TRACERx cohort dataset. F.-C.K. and M.-H.L. performed the Taiwan epidemiological analyses. F. Marongiu, E.J.E.J., C.I.T., M.G., YE.M., D.T.M. and R.L.K. generated and analysed the Duplex-seq data. O.P. wrote the Duplex-seq bioinformatics pipeline and performed the mutational signature analyses. H.C. and S.-H.L. performed the Korea epidemiological analyses. F.v.M., J.B., A.M. and  \nD.R.C. were involved in mouse data acquisition. F.S.R. was involved with organoid experiments. S.V., A.R. and C.N.-L. curated and performed DNA extractions on TRACERx and PEACE samples. T.K. helped analyse patient clinical characteristics. D.M., S.D. and  \nM.S. performed pathological assessments of human tissue samples. A.N., B.B., J.R.M.B. and C.M.-R. performed mouse RNA-seq analyses. M.H.R., R.D.H. and S.L. designed and generated data for the human crossover study. A.S.-B. And S.L.P. were involved in mouse pathology analyses. M.L., K. Lavelle, J.P., S.H. and F.E.M. curated England's National Disease Registration Service data et.  \nR.M. curated the Canadian cohort. M.A.B. and C.B. wrote and ran the MiSeq pipeline. C.A., L.H.S., Y.C. and A.M.G. performed the ddPCR experiments. I.M., J. Downward, T.J., N.K. and E.G. provided supervision for the mouse experiments. M.-J.F., M.H., P.A. and N.M. provided guidance and supervision for the bioinformatics analyses. S.L., P.S., R.H., C.T., C. D.B., A.H. and K. Litchfield provided supervision for epidemiological analyses. C.C. provided supervision for the human crossover study. J. DeGregori designed the BDRE study and supervised the healthy tissue profiling work. M.J.-H. designed the PEACE and TRACERx study protocols, and  \nE.L.L. and M.J.-H. jointly supervised the study and collaborations. C.S. supervised the work, provided strategic oversight and helped write the manuscript.  \nCompeting interests  \nM.A.B. has consulted for Achilles Therapeutics. L.H.S., Y.C. and A.M.G. have ownership interest in SAGA Diagnostics. S.V. is a co-inventor to a patent to detecting molecules in a sample (US patent 10578620) . D.A.M. reports speaker fees from AstraZeneca, Eli Lilly and Takeda, consultancy fees from AstraZeneca, Thermo Fisher, Takeda, Amgen, Janssen, MIM Software, Bristol-Myers Squibb and Eli Lilly, and has received educational support from Takeda and Amgen. C.A. has received speaking honoraria or expenses from Novartis, Roche, AstraZeneca and Bristol-Myers Squibb and reports employment at AstraZeneca. C.A. is an inventor on a European patent application relating to assay technology to detect tumour recurrence (PCT/GB2017/053289). The patent has been licensed to commercial entities and under their terms of employment, C.A is due a revenue share of any revenue generated from such licence(s) . C.A. declares a patent application (PCT/US2017/028013) for methods to detect lung cancer. C.A. is a named inventor on a patent application to ","cbCaia2kU5D5wmB1","https://ap.wps.com/l/cbCaia2kU5D5wmB1","pdf",4972192,51,"English","[{\"question\":\"What is the study focused on regarding lung adenocarcinoma?\",\"answer\":\"The study investigates how air pollutants promote lung adenocarcinoma, supported by experimental, bioinformatics, and epidemiological analyses.\"},{\"question\":\"What types of analyses were performed?\",\"answer\":\"Mouse experiments, human RNA-seq analyses, mutation literature curation, pollution-data integration, mutational signature analyses, and clinical cohort assessments are included.\"},{\"question\":\"How is the research organized across datasets and cohorts?\",\"answer\":\"The document describes work spanning multiple cohort analyses and study protocols, including UKBB and TRACERx/PEACE-related datasets, plus crossover study profiling and supervised epidemiological assessments.\"}]","Lung adenocarcinoma promotion by air pollutants | PDF",1790231184,129]