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Reports on simultaneous PC and lung cancer are rare. The study describes a 54-year-old immunocompetent patient with lung adenocarcinoma and concurrent pulmonary cryptococcal infection. Imaging with chest CT and 18F-FDG PET-CT guided surgical decision-making.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/lung-adenocarcinoma-concurrent-with-pulmonary-cryptococcosis-a-case-report-and-literature-review/333676/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/lung-adenocarcinoma-concurrent-with-pulmonary-cryptococcosis-a-case-report-and-literature-review/333676.png","ImageObject",300,407,{"name":92,"@type":93},"Oliver","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-23","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":24},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is pulmonary cryptococcosis and where does it primarily affect?","Question",{"text":112,"@type":113},"Pulmonary cryptococcosis is an opportunistic fungal infection that primarily invades the respiratory system and can subsequently involve the central nervous system.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How did clinicians evaluate the suspicious lung nodules in the case?",{"text":117,"@type":113},"Chest CT identified multiple right-lung nodules, and 18F-FDG PET-CT showed elevated glucose metabolism in a right lower-lobe dorsal segment, suggesting lung cancer.",{"name":119,"@type":110,"acceptedAnswer":120},"What treatment and follow-up outcomes were reported after surgery?",{"text":121,"@type":113},"Video-assisted thoracic surgery resected the pulmonary nodules, histopathology confirmed primary lung adenocarcinoma and pulmonary cryptococcal infection, and antifungal therapy was given for 3 months; over 3 years of follow-up, no recurrence of either disease was observed.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},333676,1790471282,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":24,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":44,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144,"preview_page_count":4},8796095461610,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","Bai etal. BMC Pulmonary Medicine (2024) 24:416 [https://doi.org/10.1186/s12890-024-03242-z](https://doi.org/10.1186/s12890-024-03242-z)  \nBMC Pulmonary Medicine  \nCASE REPORT Open Access  \nLung adenocarcinoma concurrent   \nwith pulmonary cryptococcosis: a case report and literature review  \nXiaofeng Bai 1,2†, Hansheng Wang 1,2†, Yijun Tang 1,2, Chuanyong Xiao 1,2, Yujie Gao 1,2, Hanmao Tong 1,3, Peipei Chen 1,2, Meifang Wang 1,2* and Tao Ren 1,2*  \nAbstract  \nPulmonary cryptococcosis (PC) is a common opportunistic fungal infection caused by Cryptococcus neoformans or Cryptococcus gattii. PC primarily invades the respiratory system, followed by the central nervous system. Few clinical reports have examined the coexistence of PC and lung cancer. This study reports the case of a 54-yearold immunocompetent PC patient with lung adenocarcinoma. Chest CT revealed multiple nodules in the right lung, with the largest nodule located in the dorsal segment of the right lower lobe. 18 F-FDG positron emission tomography-computed tomography (PET-CT) revealed elevated glucose metabolism in the dorsal segment of the right lower lobe, which suggested lung cancer. The metabolism level of the nodule in the basal segment of the right lower lobe and the anterior segment of the right upper lobe was not abnormally increased, but the possibility of a malignant tumour could not be excluded. The pulmonary nodules in the dorsal segment and the basal segment of the right lower lobe were simultaneously resected via video-assisted thoracic surgery (VATS), and the final histopathology revealed primary lung adenocarcinoma and pulmonary cryptococcal infection, respectively. After surgery, antifungal treatment was administered for 3 months. Over the 3-year follow-up, contrast-enhanced computed tomography (CT) revealed no recurrence of either disease. This case study highlights the possibility of dualism in the diagnosis of multiple pulmonary nodules on chest CT, such as the coexistence of lung cancer and PC. Surgical resection is recommended for micronodules that are not easy to diagnose via needle biopsy; in addition, early diagnosis and treatment are helpful for ensuring a good prognosis. This paper reports the clinical diagnosis and treatment of one patient with pulmonary cryptococcal infection of the right lung complicated with lung adenocarcinoma, including 3 years of follow-up, providing a reference for clinical practice.  \nKeywords Pulmonary cryptococcosis, Lung adenocarcinoma, Coexistence, Video-assisted thoracoscopic surgery, Fluconazole  \n†Xiaofeng Bai and Hansheng Wang contributed equally to this work.  \n*Correspondence: Meifang Wang [wmfpps02@hotmail.com](wmfpps02@hotmail.com)[ ](wmfpps02@hotmail.com)Tao Ren [doctorrentao@sina.com](doctorrentao@sina.com)  \n1Department of the First Clinical College, Hubei University of Medicine, Renmin Road No. 30, Shiyan 442000, Hubei, China  \n2Department of Pulmonary and Critical Care Medicine, Taihe Hospital, Hubei University of Medicine, 32 Renmin South Road, Maojian District, Shiyan 442000, Hubei, P. R. China  \n3Department of Pathology, Taihe Hospital, Hubei University of Medicine, 32 Renmin South Road, Maojian District, Shiyan 442000, Hubei, P. R. China  \n© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Cre","cbCaitQtIgd10xgf","https://ap.wps.com/l/cbCaitQtIgd10xgf","pdf",2111432,"English","# Abstract\n## Introduction","[{\"question\":\"What is pulmonary cryptococcosis and where does it primarily affect?\",\"answer\":\"Pulmonary cryptococcosis is an opportunistic fungal infection that primarily invades the respiratory system and can subsequently involve the central nervous system.\"},{\"question\":\"How did clinicians evaluate the suspicious lung nodules in the case?\",\"answer\":\"Chest CT identified multiple right-lung nodules, and 18F-FDG PET-CT showed elevated glucose metabolism in a right lower-lobe dorsal segment, suggesting lung cancer.\"},{\"question\":\"What treatment and follow-up outcomes were reported after surgery?\",\"answer\":\"Video-assisted thoracic surgery resected the pulmonary nodules, histopathology confirmed primary lung adenocarcinoma and pulmonary cryptococcal infection, and antifungal therapy was given for 3 months; over 3 years of follow-up, no recurrence of either disease was observed.\"}]","Lung adenocarcinoma concurrent with pulmonary cryptococcosis - a case report and literature review | PDF",1790003568,23]