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This study investigates Lysophosphatidylcholine acyltransferase 1 (LPCAT1), reported to be overexpressed in multiple cancers but with unclear function in CRC. Bioinformatics, tissue expression analysis, and iTRAQ-based quantitative proteomics are used to test LPCAT1’s role in CRC progression and underlying pathway signaling, including links to the extracellular matrix (ECM) receptor interaction program. LPCAT1 knockdown disrupts proliferation, migration, invasion, and tumor growth, highlighting the ECM-associated mechanism.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/lpcat1-depletion-inhibits-colorectal-cancer-tumorigenesis-and-is-associated-with-the-ecmreceptor-interaction-signaling-pathway/345547/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/lpcat1-depletion-inhibits-colorectal-cancer-tumorigenesis-and-is-associated-with-the-ecmreceptor-interaction-signaling-pathway/345547.png","ImageObject",300,407,{"name":92,"@type":93},"Miles","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-23","2026-09-22",true,{"@type":102,"interactionType":103,"userInteractionCount":14},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is LPCAT1 and why is it studied in colorectal cancer?","Question",{"text":112,"@type":113},"LPCAT1 is an enzyme involved in phosphatidylcholine metabolism and has been reported to be upregulated in several tumors. Its role in colorectal cancer and its mechanism require further clarification, which this study addresses.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How was LPCAT1 linked to colorectal cancer progression?",{"text":117,"@type":113},"The study uses bioinformatics to associate LPCAT1 with CRC, measures LPCAT1 expression in CRC and paired para-cancer tissues, and examines correlations with tumor stage.",{"name":119,"@type":110,"acceptedAnswer":120},"What happens when LPCAT1 is depleted in colorectal cancer models?",{"text":121,"@type":113},"LPCAT1 depletion reduces cell proliferation, migration, and invasion in vitro and arrests tumor growth in vivo.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},345547,1790196807,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":14,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},13056703019404,"https://ap-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0","[www. nature.com/scientificreports](www. nature.com/scientificreports)  \nOPEN  \nLPCAT1 depletion inhibits colorectal cancer tumorigenesis and is associated with the ECMreceptor-interaction signaling pathway  \nLiping Jiang1,2,3,4,6, Sumei Xu1,2,3,4,6, Jingbo Peng1,2,3,4, Jing Yu1,2,3,4, Huilan Wu1,2,3,4, Wei Wu1,2,3,4, Zhichun Huang1,2,3,4, Jie Pan5 & Zhirong Tan1,2,3,4􀀍  \nColorectal cancer (CRC) has become one of the most important diseases due to its increasing morbidity and mortality. Lysophosphatidylcholine acyltransferase 1 (LPCAT1) is reported to be overexpressed in multiple cancers, but their role remains poorly understood. In this study, we explored the role of LPCAT1 in the progression ofCRC and the possible underlying mechanism. Bioinformatics analysis was used to search for the association between target gene LPCAT1 and CRC. LPCAT1 expression was measured in CRC and paired para cancerous tissues. The role of LPCAT1 was investigated both in vitro and in vivo. iTRAQ-based quantitative proteomics was used to explore the mechanism of LPCAT1 inCRC progression. TCGA and GEO database analysis showed that LPCAT1 was upregulated inCRC. LPCAT1 was upregulated inCRC tissues and the IHC score was also correlated with tumor stage. The depletion of LPCAT1 not only abrogated cell proliferation, migration and invasion in vitro, but also arrested tumor growth in vivo. The proteomic results showed that differentially expressed proteins were enriched in multiple pathways after LPCAT1 knockdown, and the extracellular matrix (ECM) receptor interaction pathway was the most significant. The ECM is involved in the process by which LPCAT1 promotes CRC metastasis and invasion.  \nKeywords LPCAT1, Colorectal cancer, ECM pathway, Migration and invasion, Proteomics  \nColorectal cancer (CRC) is the third most common malignant tumor in the world, and the second leading cause of cancer death1. It is predicted that by 2030, the incidence of colorectal cancer in 20–34 year old will increase by 90.0% and 124.2%2. However, the etiology of CRC is still not clear so far, and the current studies only found that it has a certain genetic tendency and is closely related to inflammatory responses3,4. In addition, modifiable environmental risk factors such as obesity, poor diet, smoking and drinking have also been proved to be associated with CRC1. Studies have found that CRC patients are often accompanied by lipid metabolism disorder, and substances such as triglyceride (TAG)5, phosphatidylcholine (PC)6 are considered to be the main lipid markers in the progress ofCRC.  \nBiological and epidemiological evidence has shown that tumor cells rely on reprogramming of lipid metabolism to maintain survival and growth7,8, and up-regulated lipid uptake contributes to distant metastasis of tumor cells9. Abnormal lipid metabolism is considered to be one of the main contributing factors of CRC10, and studies have shown that abnormal lipid metabolism in CRC patients increases the risk of recurrence and metastasis, and leads to a poor prognosis11. And the altered lipid metabolism usually occurs in highly proliferating cancer cells due to the urgent requirement of cellular building blocks, including biological membranes9. Lipid  \n1Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, P. R. China.  \n2Hunan Key Laboratory of Pharmacogenetics, Institute of Clinical Pharmacology, Central South University, Changsha 410078, P. R. China. 3Engineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education, Changsha 410078, P. R. China. 4National Clinical Research Center for Geriatric Disorders, Changsha 410008, P. R. China. 5Clinical Research Laboratory, The Second Affiliated Hospital of University of South China, Hengyang 421001, P. R. China. 6Liping Jiang and Sumei Xu contributed equally to this work. 􀀍 email: [803119@csu.edu.cn](803119@csu.edu.cn)  \n[www. nature.com/scientificreports/](www. nature.com/scientific","cbCain5l12eZBO4T","https://ap.wps.com/l/cbCain5l12eZBO4T","pdf",3275754,13,"English","# Introduction\n## Background on CRC and lipid metabolism\n## Rationale for studying LPCAT1 in CRC\n# Methods and Materials\n## Bioinformatics analysis\n# Results (implied in abstract)\n## LPCAT1 upregulation in CRC and correlation with tumor stage\n## Functional effects of LPCAT1 depletion\n## Proteomics and ECM receptor interaction pathway","[{\"question\":\"What is LPCAT1 and why is it studied in colorectal cancer?\",\"answer\":\"LPCAT1 is an enzyme involved in phosphatidylcholine metabolism and has been reported to be upregulated in several tumors. Its role in colorectal cancer and its mechanism require further clarification, which this study addresses.\"},{\"question\":\"How was LPCAT1 linked to colorectal cancer progression?\",\"answer\":\"The study uses bioinformatics to associate LPCAT1 with CRC, measures LPCAT1 expression in CRC and paired para-cancer tissues, and examines correlations with tumor stage.\"},{\"question\":\"What happens when LPCAT1 is depleted in colorectal cancer models?\",\"answer\":\"LPCAT1 depletion reduces cell proliferation, migration, and invasion in vitro and arrests tumor growth in vivo.\"}]","LPCAT1 depletion inhibits colorectal cancer tumorigenesis and is associated with the ECMreceptor-interaction signaling pathway | PDF",1790058054,33]