[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-349213-105":59,"doc-detail-349213-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","low-level-of-selenium-predicts-high-incidence-of-colorectal-cancer","Low level of selenium predicts high incidence of colorectal cancer","","Investigate the relationship between selenium status and colorectal cancer (CRC) incidence using a systematic review and meta-analysis of studies evaluating selenium exposure and CRC risk. Databases including PubMed, Embase, and Web of Science were searched, and serum concentration, dietary intake, or tissue selenium measures were eligible. Sixteen studies contributed to pooled estimates using a random-effects model. Higher selenium exposure correlated with lower CRC risk (RR 0.81, 95% CI 0.72–0.91), with protective effects varying by design, region, and cancer site.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/low-level-of-selenium-predicts-high-incidence-of-colorectal-cancer/349213/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/low-level-of-selenium-predicts-high-incidence-of-colorectal-cancer/349213.png","ImageObject",300,407,{"name":92,"@type":93},"Pentious","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-22",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What was the main goal of the study?","Question",{"text":112,"@type":113},"To examine the association between selenium and the incidence risk of colorectal cancer (CRC).","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were studies identified and selected?",{"text":117,"@type":113},"A systematic search of PubMed, Embase, and Web of Science identified studies measuring selenium exposure (serum, dietary intake, or tissue levels) and reporting CRC risk.",{"name":119,"@type":110,"acceptedAnswer":120},"What were the overall findings on selenium and CRC risk?",{"text":121,"@type":113},"Higher selenium exposure was associated with a reduced CRC risk (RR 0.81, 95% CI 0.72–0.91), and dietary selenium intake showed a protective effect.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},349213,1790473003,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},1374404730887,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","Ying et al. BMC Public Health (2026) 26:1707 [https://doi.org/10.1186/s12889-026-26379-4](https://doi.org/10.1186/s12889-026-26379-4)  \nBMC Public Health  \nRESEARCH Open Access  \nLow level of selenium predicts high incidence of colorectal cancer  \nJiacheng Ying1, Hongsheng Fang2, Cheng Zhang1, Tianlong Ling1 and Jiayin Tang1*  \nAbstract  \nBackground To investigate the relationship between selenium and its role in the incidence of colorectal cancer (CRC) .  \nMethods A systematic review and meta-analysis was conducted by searching PubMed, Embase, and Web of Science databases to identify studies evaluating the association between selenium exposure and CRC risk. Studies assessing selenium by serum concentration, dietary intake, or tissue level were eligible. The relative risk (RR) and 95% confidence interval (CI) were calculated using the random effects model.  \nResults A total of 16 studies were included, and the overall pooled analysis showed that higher selenium exposure was associated with a reduced risk of CRC (RR = 0 . 81, 95% CI = 0 .72–0. 91) . When stratified by study design, significant inverse associations were observed in both cohort studies (RR = 0 . 84, 95% CI = 0 .78–0. 90) and case-control studies (RR = 0 . 76, 95% CI = 0 .64–0. 92) . Subgroup analyses revealed significant inverse associations in European (RR = 0 . 81, 95% CI = 0 .67–0. 98) and Oceanian (RR = 0 . 70, 95% CI = 0 .56–0. 87) populations, and in colon cancer (RR = 0 . 81, 95% CI = 0 .68– 0. 97) but not rectal cancer. Dietary selenium intake showed a protective effect (RR = 0 . 74, 95% CI = 0 .63–0. 86), whereas serum and toenail selenium were not significantly associated with CRC risk.  \nConclusion Collectively, our findings indicate that selenium sufficiency is linked to a lower risk of colorectal cancer. The results emphasize the potential role of selenium status as a modifiable nutritional factor in colorectal cancer prevention and warrant further mechanistic and interventional research.  \nKeywords Selenium, Colorectal cancer, Diet, Prognosis, Meta-analysis  \nIntroduction  \nSelenium is a trace micronutrient essential for optimal body functioning and for proper growth and development of organisms, such as selenocysteine and selenomethionine. Selenium is a naturally occurring trace element that is essential for human health but may become toxic  \n*Correspondence:  \nJiayin Tang  \n[jiayintang@shsmu.edu.cn](jiayintang@shsmu.edu.cn)  \n1Department of gastrointestinal surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China 2Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, Shanghai, China  \nat higher levels; however, its safe range of exposure has not been clearly defined. Nevertheless, selenium exposure and supplementation have been suggested to have a potential protective role against several types of cancer [1]. As a component of selenoproteins, selenium plays a crucial role in the regulation of various cell signaling pathways, which are essential for the proper functioning of the cell. These pathways control a wide range of cellular processes, including growth, proliferation, differentiation, and apoptosis. Selenium-containing selenoproteins, such as glutathione peroxidase (GPx) and thioredoxin reductase (TrxR), act as potent antioxidants, scavenging reactive oxygen species (ROS) and protecting cells  \n© The Author(s) 2026. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in thi","cbCairV5DV4hEnaN","https://ap.wps.com/l/cbCairV5DV4hEnaN","pdf",2261378,11,"English","# Abstract\n# Background\n# Methods\n## Search strategy\n## Eligibility criteria\n## Data analysis\n# Results\n# Conclusion\n# Keywords","[{\"question\":\"What was the main goal of the study?\",\"answer\":\"To examine the association between selenium and the incidence risk of colorectal cancer (CRC).\"},{\"question\":\"How were studies identified and selected?\",\"answer\":\"A systematic search of PubMed, Embase, and Web of Science identified studies measuring selenium exposure (serum, dietary intake, or tissue levels) and reporting CRC risk.\"},{\"question\":\"What were the overall findings on selenium and CRC risk?\",\"answer\":\"Higher selenium exposure was associated with a reduced CRC risk (RR 0.81, 95% CI 0.72–0.91), and dietary selenium intake showed a protective effect.\"}]","Low level of selenium predicts high incidence of colorectal cancer | PDF",1790082235,28]