[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-380714-105":59,"doc-detail-380714-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","low-incidence-of-microsatellite-instability-in-gastric-cancers-and-its-association-with-the-clinicopathological-characteristics-a-comparative-study","Low incidence of microsatellite instability in gastric cancers and its association with the clinicopathological characteristics: a comparative study","","Gastric cancer is a heterogeneous disease with high mortality and limited effective therapies, where microsatellite instability (MSI) has emerged as a molecular subgroup linked to distinct clinical behavior. This study evaluated MSI incidence and status in Iranian patients using 53 samples collected between 2015 and 2020, analyzing DNA from tumoral and normal tissues via multiplex-PCR on five mononucleotide repeat markers. High MSI occurred in ~7.5% of cases and showed significant associations with older age and reduced lymph node involvement, as well as with female sex, distal location, larger tumor size, and the intestinal Lauren type.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/low-incidence-of-microsatellite-instability-in-gastric-cancers-and-its-association-with-the-clinicopathological-characteristics-a-comparative-study/380714/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/low-incidence-of-microsatellite-instability-in-gastric-cancers-and-its-association-with-the-clinicopathological-characteristics-a-comparative-study/380714.png","ImageObject",300,407,{"name":92,"@type":93},"Fans","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-27","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":81},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What was the main aim of the study on microsatellite instability (MSI) in gastric cancer?","Question",{"text":112,"@type":113},"To investigate the incidence and MSI status in Iranian gastric cancer patients and determine how MSI is associated with clinicopathological characteristics.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How was MSI status measured in the collected gastric cancer samples?",{"text":117,"@type":113},"DNA was extracted from tumoral and normal tissues and assessed using multiplex-PCR based on a five-mononucleotide repeats panel.",{"name":119,"@type":110,"acceptedAnswer":120},"Which clinicopathological factors were significantly associated with high MSI in this dataset?",{"text":121,"@type":113},"High MSI was significantly associated with patients aged 68 years and older and with lower lymph node involvement, and it was more frequent in females, in distal gastric location, with larger tumor size, and in the intestinal type rather than the diffuse type.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},380714,1790392962,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":81,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},5909892330395,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","[www. nature.com/scientificreports](www. nature.com/scientificreports)  \nOPEN  \nLow incidence of microsatellite instability in gastric  \ncancers and its association with the clinicopathological characteristics: a comparative study  \nFateme FooladiTalari1, Ali Bozorg1*, Sirous Zeinali2,3, Mohammadreza Zali4, Zhale Mohsenifar 5, Hamid AsadzadehAghdaei4 & Kaveh Baghaei4*  \nGastric cancer is a complex heterogeneous disease with different molecular subtypes that have clinical implications. It is characterized by high mortality rates and limited effective therapies. Microsatellite instability (MSI) has been recognized as a subgroup with a good prognosis based on TCGA andACRG categorizations. Besides its prognostic and predictive value, gastric cancers with high MSI exhibit different clinical behaviors. The prevalence of high MSI has been assessed in gastric cancer worldwide, especially in East Asia, but there is a lack of such information in the Middle East. Therefore, this study aimed to investigate the incidence and status of MSI in Iranian gastric cancer patients using 53 samples collected from 2015 to 2020 atTaleghani Hospital Medical Center. DNA from tumoral and normal tissues were extracted and assessed through multiplex-PCR based on five mononucleotide repeats panel. Clinicopathological variables, including age, sex, Lauren classification, lymph node involvement, TNM stage, differentiation, localization, and tumor size, were also analyzed. With 2 males and 2 females, high microsatellite instability represented a small subgroup of almost 7.5% of the samples with a median age of 60.5 years. High microsatellite instability phenotypes were significantly associated with patients aged 68 years and older (p-value of 0.0015) and lower lymph node involvement (p-value of 0.0004). Microsatellite instability was also more frequent in females, with distal gastric location, bigger tumor size, and in the intestinal type of gastric cancer rather than the diffuse type.  \nGastric cancer (GC) is the second most common cancer type and the leading cause of cancer-related death in Iran, with approximately 14,656 new cases (9599 males, 5057 females) reported in 2020, as per Globocan 2020 report1.  \nIn the early stages, GC develops with mild gastrointestinal symptoms. Therefore, most patients are usually diagnosed in advanced stages when therapeutic approaches fail, leading to poor prognosis and overall survival2. Various treatment approaches have been employed globally, but not all patients benefit from adjuvant chemotherapy, and adverse effects have been reported3. Furthermore, GC has been identified as a complex and heterogeneous disease. Evidence indicates that GC prognosis and treatment outcomes depend not only on the tumor stage, but also on the molecular and genetic features4,5. Different classifications have been introduced for GC. Lauren histological classification, comprised of two intestinal and diffuse subtypes, was first introduced  \n1Biotechnology Department, College of Science, University of Tehran, Tehran, Iran. 2Dr. Zeinali’s Medical Genetics Laboratory, Kawsar Human Genetics Research Center, Tehran, Iran. 3Department of Molecular Medicine, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran. 4Research Institute for Gastroenterology and Liver Diseases, Gastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 5Department of Pathology, School of Medicine, Taleghani Hospital, Shahid Beheshti  \nUniversity of Medical Sciences, Tehran, Iran.* email: [abozorg@ut.ac.ir](abozorg@ut.ac.ir); [kavehbaghai@gmail.com](kavehbaghai@gmail.com)  \n[www. nature.com/scientificreports/](www. nature.com/scientificreports/)  \nin 19656 and recently updated for more clarification of histological features7. Another classification based on morphological patterns, including mucinous (colloid), tubular, papillary, and mixed carcinoma, but with no correlations with prognosis, has been su","cbCaiozmUOUXarXA","https://ap.wps.com/l/cbCaiozmUOUXarXA","pdf",2705177,11,"English","# Background and rationale\n## Gastric cancer heterogeneity and molecular subtypes\n## MSI definition and relevance\n# Study aim and patient material\n## Study setting and sample collection\n## MSI assessment method\n# Clinicopathological associations\n## Demographics and disease features\n## Statistical associations and subgroup patterns","[{\"question\":\"What was the main aim of the study on microsatellite instability (MSI) in gastric cancer?\",\"answer\":\"To investigate the incidence and MSI status in Iranian gastric cancer patients and determine how MSI is associated with clinicopathological characteristics.\"},{\"question\":\"How was MSI status measured in the collected gastric cancer samples?\",\"answer\":\"DNA was extracted from tumoral and normal tissues and assessed using multiplex-PCR based on a five-mononucleotide repeats panel.\"},{\"question\":\"Which clinicopathological factors were significantly associated with high MSI in this dataset?\",\"answer\":\"High MSI was significantly associated with patients aged 68 years and older and with lower lymph node involvement, and it was more frequent in females, in distal gastric location, with larger tumor size, and in the intestinal type rather than the diffuse type.\"}]","Low incidence of microsatellite instability in gastric cancers and its association with the clinicopathological characteristics: a comparative study | PDF",1790241418,28]