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FAM96B mRNA was quantified in HCC tissues and matched non-tumorous samples by qRT-PCR, then validated using TCGA, followed by immunohistochemistry (IHC) in 137 HCC cases. Lower FAM96B protein and mRNA levels associated with larger tumors, advanced Barcelona clinic liver cancer/Child stages, and early distant metastasis, correlating with worse disease-free and overall survival and serving as an independent prognosis predictor.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/low-expression-of-fam96b-is-associated-with-poor-prognosis-in-hepatocellular-carcinoma/338720/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/low-expression-of-fam96b-is-associated-with-poor-prognosis-in-hepatocellular-carcinoma/338720.png","ImageObject",300,407,{"name":92,"@type":93},"Ophelia","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-27","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"How was FAM96B expression measured in hepatocellular carcinoma tissues?","Question",{"text":112,"@type":113},"FAM96B mRNA was measured in HCC and matched non-tumorous tissues using qRT-PCR, validated with the TCGA database. Protein level was evaluated using immunohistochemistry in 137 HCC cases.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What clinicopathological features were associated with low FAM96B expression?",{"text":117,"@type":113},"Lower FAM96B expression was linked to larger tumor size, higher Barcelona clinic liver cancer stage or Child stage, and early distant metastasis.",{"name":119,"@type":110,"acceptedAnswer":120},"Does low FAM96B expression predict patient prognosis in HCC?",{"text":121,"@type":113},"Yes. Patients with low FAM96B levels showed unfavorable disease-free and overall survival, and FAM96B remained an independent predictor in univariate and multivariate survival analyses.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},338720,1790592160,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":39,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":46},7971461741311,"https://ap-avatar.wpscdn.com/avatar/74000253aff267980c6?x-image-process=image/resize,m_fixed,w_180,h_180&k=1779345379180704826","ORIGINAL ARTICLE LIVER  \nLow Expression ofFAM96Bis Associated with Poor Prognosis in Hepatocellular Carcinoma  \nYuqun Tang \\#, Liangke Tang2\\#, Haijian Du1, Chaosheng Wu1, Zhuangxiong Wang1, Guanshui Luo1, Ke He1 1Cancer Minimally Invasive Therapies Centre, Guangdong Second Provincial General Hospital, Guangzhou, China  \n2Department of Thyroid and Breast Surgery, Southern Medical University, Hospital of Integrated Chinese and Western Medicine, Guangdong, China  \nCite this article as: Tang Y, Tang L, Du H, et al. Low expression of FAM96B is associated with poor prognosis in hepatocellular carcinoma. Turk J Gastroenterol. 2025;36(4):255-262 .  \nABSTRACT  \nBackground/Aims: Recently, studies on FAM96B functions mainly focused on its role in maintaining the normal physiological function of cells. However, the clinical implications of FAM96B in hepatocellular carcinoma (HCC) are still unclear.  \nMaterials and Methods: FAM96B mRNA expression was detected in human HCC tissues and the matched nontumorous tissues by quantitative real-time reverse transcription (qRT-PCR) and then validated in The Cancer Genome Atlas (TCGA) database. Immunohistochemistry assay (IHC) was performed on all 137 cases of HCC samples to examine the protein level of FAM96B. Subsequently, the associations between FAM96B expression and clinicopathological parameters and prognosis were further analyzed. Results: The mRNA level ofFAM96B was found to be significantly lower in HCC tissues compared to non-tumorous tissues, as observed in both the local hospital and TCGA database.Immunohistochemistry assay analysis revealed a decrease in FAM96B expression in 78 out of 137 cases, which was significantly associated with larger tumor size, higher Barcelona clinic liver cancer or Child stage, and early distant metastasis. Patients with low FAM96B levels tended to have an unfavorable disease-free and overall survival. Moreover, FAM96B was identified as an independent predictor of patient prognosis in both univariate and multivariate survival analyses. Mechanistically, FAM96B was found to inhibit cancer progression by inducing apoptosis in liver cancer cells and inhibiting their growth.  \nConclusion: Our findings provide the first evidence suggesting the involvement of FAM96B in the progression of HCC. Additionally, FAM96B could potentially serve as a marker for tumor recurrence and prognosis in HCC patients.  \nKeywords: FAM96B, hepatocellular carcinoma, prognosis, immunohistochemistry  \nINTRODUCTION  \nHepatocellular carcinoma (HCC) poses a significant challenge for treatment globally.1 It is classified as the sixth most prevalent form of cancer and the third leading contributor to mortality in cancer patients. In 2020, there were nearly 900 000 newly confirmed cases and 800 000 deaths from liver cancer worldwide. More seriously, the frequency of HCC cases is expected to see an upward trend in the forthcoming period.1 So far, there is no effective treatment for HCC. Common treatments include surgical resection,2 liver transplantation,2 radiofrequency ablation, and hepatic artery chemoembolization.3 Tyrosine kinase inhibitors, such as sorafenib,4 levotinib,5 and regglinide,6 have limited efficacy. Human HCC is generally believed to be closely related to hepatitis B virus (HBV) and hepatitis C virus (HCV) infection,7 aflatoxin B1, non-alcoholic fatty liver disease, cirrhosis, and long-term alcohol consumption.8-10 Development of HCC is related  \nto many factors including the stimulation of oncogenes, the deactivation of genes with tumor-suppressive functions, and tumor metastasis suppressor genes.11 Given the limitations of traditional treatment for HCC, it is crucial to identify novel targets and prognosis predictors. This approach holds promise for treating cancers and facilitating precision medicine.  \nFAM96B (family with sequence similarity 96, member B) is located in 16q22.1-q22.3 . It is a gene originally discovered by comparing the genomes of humans and nematodes based o","cbCaifVEGf0sfw7n","https://ap.wps.com/l/cbCaifVEGf0sfw7n","pdf",1592019,"English","# Abstract\n## Background/Aims\n## Materials and Methods\n## Results\n## Conclusion\n# Introduction","[{\"question\":\"How was FAM96B expression measured in hepatocellular carcinoma tissues?\",\"answer\":\"FAM96B mRNA was measured in HCC and matched non-tumorous tissues using qRT-PCR, validated with the TCGA database. Protein level was evaluated using immunohistochemistry in 137 HCC cases.\"},{\"question\":\"What clinicopathological features were associated with low FAM96B expression?\",\"answer\":\"Lower FAM96B expression was linked to larger tumor size, higher Barcelona clinic liver cancer stage or Child stage, and early distant metastasis.\"},{\"question\":\"Does low FAM96B expression predict patient prognosis in HCC?\",\"answer\":\"Yes. Patients with low FAM96B levels showed unfavorable disease-free and overall survival, and FAM96B remained an independent predictor in univariate and multivariate survival analyses.\"}]","Low Expression of FAM96B is Associated with Poor Prognosis in Hepatocellular Carcinoma | PDF",1790025270]