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Using Health and Retirement Study data from 2012–2020 (n=9,714), PA participation averaged across 2012–2020 and diagnoses of AD/ADRD (2012–2020) were modeled with a Generalized Estimating Equation while adjusting for age, sex, education, and cognitive function. Risk declined across higher PA levels, with significant reduction identified at a PA threshold of about 2.40 and stronger benefit at greater engagement, including exercise and walking at least twice weekly.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/longitudinal-estimation-of-adequate-physical-activity-levels-to-reduce-the-risk-of-dementia-in-older-adults-with-mci/427451/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/longitudinal-estimation-of-adequate-physical-activity-levels-to-reduce-the-risk-of-dementia-in-older-adults-with-mci/427451.png","ImageObject",300,407,{"name":92,"@type":93},"Levi","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-14","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What was the main objective of this study?","Question",{"text":112,"@type":113},"To estimate the adequate physical activity level needed to significantly reduce the risk of dementia (AD/ADRD) among older adults with mild cognitive impairment (MCI).","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What data and time period were used?",{"text":117,"@type":113},"The study used Health and Retirement Study data collected between 2012 and 2020, including 9,714 individuals with MCI.",{"name":119,"@type":110,"acceptedAnswer":120},"How did physical activity relate to AD/ADRD risk reduction?",{"text":121,"@type":113},"AD/ADRD risk decreased as PA levels increased, with a significant risk reduction threshold identified around the PA level near 2.40 and further reduction at higher PA engagement, including regular exercise and walking at least twice per week.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},427451,1790763449,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":8,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":81},7971461740909,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","Innovation in Aging, 2025, Vol. 9, No. S2 843  \nindicated that the risk of AD/ADRD decreased by 3% at a PA level of 2.20 (OR = 0 .970, 95% CI [0 .958, 0 .983]) and exhibited a linear declining trend with increasing PA levels: a 3.3% decrease at 2.40 (OR = 0 .967, 95% CI [0 .956, 0.979]), a 3. 8% decrease  \nat 2.60 (OR = 0 .962, 95% CI [0 .948, 0.975]), and a 4. 6% decrease at 2.80 (OR = 0.954, 95% CI [0.946, 0.964]). Engaging in exercise and walking at least twice a week was identified asthe threshold for achieving a significant reduction in the risk of AD/ADRD, with greater PA engagement further enhancing risk reduction in older adults with MCI.  \nAbstract citation ID: igaf122.2856  \nLONGITUDINAL ESTIMATION OF ADEQUATE  \nPHYSICAL ACTIVITY LEVELS TO REDUCE THE RISK  \nOF DEMENTIA IN OLDER ADULTS WITH MCI  \nJungjoo Lee1, Junhyoung Kim2, Donghyuck Cho3, and Min Jun Hwang4, 1. Texas A&M University, Texas A&M University, Texas, United States, 2. Texas A&M University, College Station, Texas, United States, 3. Cranbrook Academy of Art, Bloomfield Hills, Michigan, United States, 4. Phillips Exeter Academy, Exeter, New Hampshire, United States  \nThis study estimated the level of physical activity (PA) required to reduce the risk of Alzheimer’s disease and related dementias (AD/ADRD), focusing on identifying the adequate PA level to achieve significant risk reduction among older adults with Mild Cognitive Impairment (MCI). This longitudinal study investigated Health and Retirement Study data between 2012 and 2020. The sample included 9,714 individuals with MCI, screened using the Telephone Interview for Cognitive Status-27 at baseline in 2012. The dependent variable was the diagnosis of AD or ADRD between 2012 and 2020. To ensure reliability, this study included participants who responded to the diagnosis questions in a consistent chronological order. The independent variable was the average level of PA participation, including activities such as exercise and walking, from 2012 to 2020. Covariates included age, sex, education, and cognitive function. A Generalized Estimating Equation was used for analysis. Results","cbCaiiuDrZrAy8a3","https://ap.wps.com/l/cbCaiiuDrZrAy8a3","pdf",755392,"English","# Methods\n## Data source and sample\n## Variables and statistical analysis\n# Results\n## PA threshold and risk reduction trend\n# Conclusion\n## Practical implications for PA engagement","[{\"question\":\"What was the main objective of this study?\",\"answer\":\"To estimate the adequate physical activity level needed to significantly reduce the risk of dementia (AD/ADRD) among older adults with mild cognitive impairment (MCI).\"},{\"question\":\"What data and time period were used?\",\"answer\":\"The study used Health and Retirement Study data collected between 2012 and 2020, including 9,714 individuals with MCI.\"},{\"question\":\"How did physical activity relate to AD/ADRD risk reduction?\",\"answer\":\"AD/ADRD risk decreased as PA levels increased, with a significant risk reduction threshold identified around the PA level near 2.40 and further reduction at higher PA engagement, including regular exercise and walking at least twice per week.\"}]","LONGITUDINAL ESTIMATION OF ADEQUATE PHYSICAL ACTIVITY LEVELS TO REDUCE THE RISK OF DEMENTIA IN OLDER ADULTS WITH MCI | PDF",1790643894]