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The study leverages an OPMD surveillance program spanning 25 years and more recent electronic health record search methods to analyze 1500+ patients across a 10-year period, representing about 20% of total referrals. Results quantify conversion timing, lesion types, and cancer representation within oral and oropharyngeal sites.",{"@graph":69,"@context":127},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/longitudinal-analysis-of-oral-potentially-malignant-disorder-conversion-to-malignancy/366978/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/longitudinal-analysis-of-oral-potentially-malignant-disorder-conversion-to-malignancy/366978.png","ImageObject",300,407,{"name":92,"@type":93},"pixelkiddo","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-03","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119,123],{"name":110,"@type":111,"acceptedAnswer":112},"What are oral potentially malignant disorders (OPMDs) in this study?","Question",{"text":113,"@type":114},"OPMDs are local and systemic conditions that can result in oral malignancies. The paper frames them as high-risk states requiring surveillance for malignant conversion.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How were patient records identified and de-identified?",{"text":118,"@type":114},"Electronic health record information was queried using 24 ICD-9/10 codes to generate a de-identified dataset. Records were cross-referenced against 79 ICD-9/10 codes associated with oral and oropharyngeal cancers.",{"name":120,"@type":111,"acceptedAnswer":121},"What did the study find about malignant conversion timing and lesion types?",{"text":122,"@type":114},"Among 1535 included records, 72 patients showed cancerous conversion (4.69%). A substantial share occurred before 5 years (55 patients), while others occurred after 5 years (17 patients).",{"name":124,"@type":111,"acceptedAnswer":125},"Why is longer-term surveillance emphasized?",{"text":126,"@type":114},"Because significant conversions occurred after 5 years, the study suggests OPMD conditions likely need longer-term surveillance analogous to other long-latency cancers.","https://schema.org",{"og:url":83,"og:type":129,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":131,"canonical":83},"index,follow",{"doc_id":133,"site_id":62},366978,1790763452,{"code":4,"msg":5,"data":136},{"doc_id":133,"user_id":137,"nickname":92,"user_avatar":138,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":139,"file_id":140,"file_url":141,"file_type":142,"file_size":143,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":34,"language":144,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":145,"faqs":146,"seo_title":147,"seo_description":67,"update_tm":148,"read_time":149},962090883892,"https://ap-avatar.wpscdn.com/avatar/e00115db34f3e0f11b?x-image-process=image/resize,m_fixed,w_180,h_180&k=1790152879550218658","The Laryngoscope   \n ORIGINAL REPORT  OPEN ACCESS   \nLongitudinal Analysis of Oral Potentially Malignant Disorder Conversion to Malignancy  \nBenjamin Palatnik1  | Lindsey Mortensen1 | Aleksandr Palatnik2 | Beverly R. Wuertz3 | Frank G. Ondrey3   \n1University of Minnesota Medical School-Twin Cities, Minneapolis, Minnesota, USA | 2Itec Engineering LLC, Pewaukee, Wisconsin,  \nUSA | 3Department of Otolaryngology, University of Minnesota, Minneapolis, Minnesota, USA Correspondence: Benjamin Palatnik ([palat020@umn.edu](palat020@umn.edu))  \nReceived: 12 August 2025 | Accepted: 29 September 2025  \nFunding: This work was supported by the NCI Division of Cancer Prevention (5R01CA254270-02). This research was also supported by the National Institutes of Health's National Center for Advancing Translational Sciences, grant UM1TR004405. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health's National Center for Advancing Translational Sciences.  \nKeywords: epidemiological studies | head and neck | oral cavity  \nABSTRACT  \nObjectives: Oral potentially malignant disorders (OPMDs) are local and systemic conditions that can result in oral malignancies. We have had an OPMD surveillance program for 25 years covering over 30% of our state's population. More recent electronic health record search techniques have allowed us to analyze over 1500 patients in over a 10-year period, approximately 20% of total referrals.  \nMethods: Electronic health record (EHR) information was queried for 24 International Classification of Disease (ICD) 9 and 10 codes to generate a de-identified data set. Charts within this data set were cross-referenced against 79 ICD9/10 codes corresponding to oral and oropharyngeal cancers. The time course of conversion and frequencies of precancerous and cancerous lesions was assessed.  \nResults: Of 4496 unique patients seen, 1535 patient records met inclusion criteria. Seventy two patients showed cancerous conversion (4.69%), with 55 (3.58%) before 5 years, and 17 (1.11%) after a 5-year surveillance period. Leukoplakia and OLP patients constituted 34.7% of conversions, though other lesions/diseases of the tongue/oral mucosa showed conversion. Tongue cancers were the most represented carcinomas, followed by carcinomas of the oropharynx.  \nConclusion: We discovered overall rates of malignant conversion within the broad range reported in the world literature (0%–60%) . Importantly, this living data set can be repeatedly queried over time to discover significant malignant conversions, potentially over decades. With significant conversions occurring after 5 years, OPMD conditions likely require longer-term surveillance like colon, breast, or other cancers.  \nLevel of Evidence: 3.  \n1 | Introduction  \nThere are expected to be close to 60,000 oropharyngeal malignancies in the US in 2025 [1] . Many of these malignancies  \nare preceded by oral potentially malignant disorders (OPMDs)[2, 3]. A plethora of OPMDs have been described over the past 40 years, including leukoplakia (OL), oral lichen planus (OLP), oral lichenoid lesions, Fanconi Anemia, solid organ and bone  \n\n| This work was initially presented at the 2024 Triological Society Combined Sections Meeting in Orlando, Florida. |\n| --- |\n| This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.\u003Cbr>© 2025 The Author(s) . The Laryngoscope published by Wiley Periodicals LLC on behalf of The American Laryngological, Rhinological and Otological Society, Inc. |\n\nThe Laryngoscope, 2026; 136:1755–1761 1755  \n[https://doi.org/10.1002/lary.70199](https://doi.org/10.1002/lary.70199)  \nmarrow transplantation history, glossitis, submucosal fibrosis, and more [4–6] . Classically, tobacco and alcohol are the principal risk factors for leukoplakia [7] . Leukoplakia, w","cbCaial4vlRIT6I9","https://ap.wps.com/l/cbCaial4vlRIT6I9","pdf",370382,"English","# Abstract\n## Objectives\n## Methods\n## Results\n## Conclusion\n## Level of Evidence\n# Introduction","[{\"question\":\"What are oral potentially malignant disorders (OPMDs) in this study?\",\"answer\":\"OPMDs are local and systemic conditions that can result in oral malignancies. The paper frames them as high-risk states requiring surveillance for malignant conversion.\"},{\"question\":\"How were patient records identified and de-identified?\",\"answer\":\"Electronic health record information was queried using 24 ICD-9/10 codes to generate a de-identified dataset. Records were cross-referenced against 79 ICD-9/10 codes associated with oral and oropharyngeal cancers.\"},{\"question\":\"What did the study find about malignant conversion timing and lesion types?\",\"answer\":\"Among 1535 included records, 72 patients showed cancerous conversion (4.69%). A substantial share occurred before 5 years (55 patients), while others occurred after 5 years (17 patients).\"},{\"question\":\"Why is longer-term surveillance emphasized?\",\"answer\":\"Because significant conversions occurred after 5 years, the study suggests OPMD conditions likely need longer-term surveillance analogous to other long-latency cancers.\"}]","Longitudinal Analysis of Oral Potentially Malignant Disorder Conversion to Malignancy | PDF",1790168538,18]