[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-380801-105":59,"doc-detail-380801-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","long-term-safety-of-growth-hormone-deficiency-treatment-in-cancer-and-sellar-tumors-adult-survivors-is-there-a-role-of-gh-therapy-on-the-neoplastic-risk","Long-Term Safety of Growth Hormone Deficiency Treatment in Cancer and Sellar Tumors Adult Survivors - Is There a Role of GH Therapy on the Neoplastic Risk","","Experimental evidence indicates that GH/IGF-1 status may affect neoplastic tissue growth, while epidemiological data suggest an association between GH/IGF-1 status and cancer risk. Observations in childhood cancer survivors receiving GH replacement do not show an excess of de novo cancers, and reported studies in children and adults treated with GH do not demonstrate increased observed cancer risk. This review provides an overview of long-term effects of GH replacement on neoplastic risk in adult survivors with growth hormone deficiency and sellar tumors.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/long-term-safety-of-growth-hormone-deficiency-treatment-in-cancer-and-sellar-tumors-adult-survivors-is-there-a-role-of-gh-therapy-on-the-neoplastic-risk/380801/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/long-term-safety-of-growth-hormone-deficiency-treatment-in-cancer-and-sellar-tumors-adult-survivors-is-there-a-role-of-gh-therapy-on-the-neoplastic-risk/380801.png","ImageObject",300,407,{"name":92,"@type":93},"RuangKosong","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-31","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What is the purpose of this review on GH therapy in adult cancer and sellar tumor survivors?","Question",{"text":113,"@type":114},"To provide an at-a-glance overview of the current evidence on the long-term effects of GH replacement on neoplastic risk in adults with growth hormone deficiency who survived cancer and sellar tumors.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"What do experimental and epidemiological studies suggest about GH/IGF-1 and cancer risk?",{"text":118,"@type":114},"Experimental studies support the hypothesis that GH/IGF-1 status may influence neoplastic tissue growth, and epidemiological studies suggest a link between GH/IGF-1 status and cancer risk.",{"name":120,"@type":111,"acceptedAnswer":121},"Do studies in childhood cancer survivors show an increase in new cancers after GH replacement?",{"text":122,"@type":114},"The review reports that several studies regarding GH replacement safety in childhood cancer survivors do not show a prevalence excess of de novo cancers, and multiple reports in children and adults treated with GH have not shown an increase in observed cancer risk.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},380801,1790751361,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146},962090883219,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","Review  \nLong-Term Safety of Growth Hormone Deficiency Treatment in Cancer and Sellar Tumors Adult Survivors: Is There a Role of GH Therapy on the Neoplastic Risk?  \nCarolina Di Somma 1,2,*, Elisabetta Scarano 1, Rossana Arianna 1, Fiammetta Romano 1, Mariarosaria Lavorgna 1, Domenico Serpico 1 and Annamaria Colao 1,2  \nCitation: Di Somma, C.; Scarano, E.; Arianna, R.; Romano, F.; Lavorgna, M.; Serpico, D.; Colao, A. Long-Term Safety of Growth Hormone Deficiency Treatment in Cancer and Sellar Tumors Adult Survivors: Is There a Role of GH Therapy on the Neoplastic Risk?. J. Clin. Med. 2023, 12, 662. [https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)jcm12020662  \nAcademic Editor: Cees Noordam  \nReceived: 20 December 2022  \nRevised: 7 January 2023  \nAccepted: 12 January 2023  \nPublished: 13 January 2023  \nCopyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Endocrinology, Diabetes and Andrology Unit, Department of Clinical Medicine and Surgery, University of Naples “Federico II”, 80131 Naples, Italy  \n2 UNESCO Chair “Education for Health and Sustainable Development”, University of Naples “Federico II”, 80131 Naples, Italy  \n* Correspondence: [cdisomma@unina.it](cdisomma@unina.it)  \nAbstract: Experimental studies support the hypothesis that GH/IGF-1 status may influence neoplastic tissue growth. Epidemiological studies suggest a link between GH/IGF-1 status and cancer risk. However, several studies regarding GH replacement safety in childhood cancer survivors do not show a prevalence excess of de novo cancers, and several reports on children and adults treated with GH have not shown an increase in observed cancer risk in these patients. The aim of this review is to provide an at-a-glance overview and the state of the art of long-term effects of GH replacement on neoplastic risk in adults with growth hormone deficiency who have survived cancer and sellar tumors.  \nKeywords: GH treatment; cancer risk; GHD  \n1. Introduction  \nSince t mass manufacture began in 1985, the biosynthetic growth hormone (GH) has been used to treat both growth hormone deficiency (GHD) in adults and a variety of disorders in children linked to short stature, with different approved purposes in different nations [1] . Due to the development of GHD associated with the malignancy and/or severe effects of its treatment, including chemotherapy, surgery, radiation, and biological therapy (antigen–specific monoclonal antibodies and cytotoxic T-cells), certain cancer survivors may need to be treated with GH. Over the past forty years, there has been a significant improvement in cancer treatment, leading to a significant rise in the number of cancer survivors. Childhood cancer treatment frequently results in poor longitudinal growth and GHD [2] . GH replacement therapy improves symptoms and comorbidities linked to GHD in adults. This review summarizes the most recent medical literature regarding GH treatment safety in cancer and sellar tumor adult survivors, with a focus on key issues: Where clinical practice lacks clinical practice consensus.  \n2. Cancer Incidence in Adult Patients  \nCancer incidence and mortality are both rising fast globally. There are many causes, but they take into account population aging and growth, as well as shifts in the prevalence and distribution of major cancer risk factors, many of which are linked to socioeconomic development. According to previous estimates, there were 9.6 million cancer deaths and 18.1 million new cancer cases in 2018 [3] . Lung cancer, which affects both sexes equally, is the most frequently diagnosed cancer (11.6% of all cases) and the most fatal (18.4% of all cancer deaths) . It is closely","cbCaiiarFz5QdDlB","https://ap.wps.com/l/cbCaiiarFz5QdDlB","pdf",631599,15,"English","# Introduction\n# Cancer Incidence in Adult Patients\n# Cancer Risk in Adult Hypopituitary Patients","[{\"question\":\"What is the purpose of this review on GH therapy in adult cancer and sellar tumor survivors?\",\"answer\":\"To provide an at-a-glance overview of the current evidence on the long-term effects of GH replacement on neoplastic risk in adults with growth hormone deficiency who survived cancer and sellar tumors.\"},{\"question\":\"What do experimental and epidemiological studies suggest about GH/IGF-1 and cancer risk?\",\"answer\":\"Experimental studies support the hypothesis that GH/IGF-1 status may influence neoplastic tissue growth, and epidemiological studies suggest a link between GH/IGF-1 status and cancer risk.\"},{\"question\":\"Do studies in childhood cancer survivors show an increase in new cancers after GH replacement?\",\"answer\":\"The review reports that several studies regarding GH replacement safety in childhood cancer survivors do not show a prevalence excess of de novo cancers, and multiple reports in children and adults treated with GH have not shown an increase in observed cancer risk.\"}]","Long-Term Safety of Growth Hormone Deficiency Treatment in Cancer and Sellar Tumors Adult Survivors - Is There a Role of GH Therapy on the Neoplastic Risk | PDF",1790242190,38]