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A cohort of 506 adult LT recipients, including 97 ALD patients, compared outcomes with non-ALD recipients. ALD patients were stratified into 6-month abstinence versus nonabstinence groups by pretransplant withdrawal period to assess relapse drinking incidence and long-term outcomes.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/long-term-outcomes-of-liver-transplantation-for-alcohol-related-liver-disease/436966/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/long-term-outcomes-of-liver-transplantation-for-alcohol-related-liver-disease/436966.png","ImageObject",300,407,{"name":92,"@type":93},"Đào","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-07","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What question does the study address about alcohol-related liver disease after transplantation?","Question",{"text":112,"@type":113},"It evaluates whether increasing LT use for ALD negatively impacts deceased-donor allocation and whether a 6-month abstinence policy before LT prevents relapse and improves long-term outcomes.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were ALD patients grouped for comparison?",{"text":117,"@type":113},"The 97 ALD recipients were divided into group A (6-month abstinence) and group N (nonabstinence) based on the alcohol withdrawal period before transplantation.",{"name":119,"@type":110,"acceptedAnswer":120},"What was the study’s main conclusion about pretransplant abstinence and relapse risk?",{"text":121,"@type":113},"LT provided favorable outcomes for ALD, and 6-month abstinence before transplant did not predict the risk of recidivism after transplantation. De novo malignancies were a leading cause of late death in ALD patients.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},436966,1790740630,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":39,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":46,"preview_page_count":4},1374402968488,"https://ap-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0","J Chin MedAssoc  \nOriginal article  \nLong-term outcomes of liver transplantation for alcohol-related liver disease  \nNiang-Cheng Lina,b,c, Chinsu Liua,b,d, Cheng-Yen Chena,b, Hao-Jan Leib,e, Yi-Fan Tsoua,b, Fang-Cheng Kuoa,b, Shu-Cheng Choub,e, Meng-Hsuan Chunga,b, Cheng-Yuan Hsiab,e, Che-Chuan Loonga,b,e, Shen-Chih Wangb,f, Oscar K. Leec,g,h,i,j, Hsin-Lin Tsaia,b,d,*  \naDivision of Transplantation Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; bSchool of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC; cInstitute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC; dDivision of Pediatric Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; eDivision of General Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; fDepartment of Anesthesiology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; gStem Cell Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC; hDepartment of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; iDepartment of Orthopedics, China Medical University Hospital, Taichung, Taiwan, ROC; jCenter for Translational Genomics and Regenerative Medicine Research, China Medical University Hospital, Taichung, Taiwan, ROC  \nAbstract  \nBackground: Liver transplantation (LT) is being increasingly performed for alcohol-related liver disease (ALD) . It is unclear whether the increasing frequency of LTs in ALD patients has a negative impact on deceased-donor (DDLT) allocation and whether the current policy of 6 months of abstinence before transplantation effectively prevents recidivism after transplantation or improves long-term outcomes. Methods: A total of 506 adult LT recipients, including 97 ALD patients, were enrolled. The outcomes of ALD patients were compared with those of non-ALD patients. The 97 ALD patients were further divided into group A (6-month abstinence) and group N (nonabstinence) based on the pretransplant alcohol withdrawal period. The incidence of relapsed drinking and the long-term outcomes were compared between the two groups.  \nResults: The prevalence of LT for ALD significantly increased after 2016 (27 .0% vs 14.0%; p \u003C 0.01), but the frequency of DDLT for ALD remained unchanged (22 .6% vs 34. 1%, p = 0.210) . After a median follow-up of 56.9 months, patient survival was comparable between the ALD and non-ALD patients (1, 3, and 5 years posttransplant: 87.6%, 84.3%, and 79.5% vs 82.8%, 76.6%, and 72.2%, respectively; p = 0.396) . The results were consistent irrespective of the transplant type and disease severity. In ALD patients, 22 of the 70 (31 .4%) patients reported relapsed drinking after transplantation, and the prevalence in group A had a higher tendency than that in group N (38 .3% vs 17.4%, p = 0 .077) . Six months of abstinence or nonabstinence did not result in a survival difference, and de novo malignancies were the leading cause of late patient death in ALD patients.  \nConclusion: LT achieves favorable outcomes for ALD patients. Six months of abstinence pretransplant did not predict the risk of recidivism after transplantation. The high incidence of de novo malignancies in these patients warrants a more comprehensive physical evaluation and better lifestyle modifications to improve long-term outcomes.  \nKeywords: Abstinence; Alcohol-related liver disease; de novo malignancy; Liver transplantation  \n1. INTRODUCTION  \nLiver transplantation (LT) is the definitive treatment for patients with end-stage liver disease.1 Currently, viral  \n* Address correspondence. Dr. Hsin-Lin Tsai, Division of Pediatric Surgery, Division of Transplantation, Department of Surgery, Taipei Veterans General Hospital, 201, Section 2, Shi-Pai Road, Taipei 112, Taiwan, ROC. E-mail address:  \n[hltsai@vghtpe.gov.tw](hltsai@vghtpe.gov.tw) (H.-L. Tsai)  \nConflicts of interest: The authors declare that they","cbCaifTbEkKlaJas","https://ap.wps.com/l/cbCaifTbEkKlaJas","pdf",608530,"English","# Abstract\n## Background\n## Methods\n## Results\n## Conclusion\n# Introduction","[{\"question\":\"What question does the study address about alcohol-related liver disease after transplantation?\",\"answer\":\"It evaluates whether increasing LT use for ALD negatively impacts deceased-donor allocation and whether a 6-month abstinence policy before LT prevents relapse and improves long-term outcomes.\"},{\"question\":\"How were ALD patients grouped for comparison?\",\"answer\":\"The 97 ALD recipients were divided into group A (6-month abstinence) and group N (nonabstinence) based on the alcohol withdrawal period before transplantation.\"},{\"question\":\"What was the study’s main conclusion about pretransplant abstinence and relapse risk?\",\"answer\":\"LT provided favorable outcomes for ALD, and 6-month abstinence before transplant did not predict the risk of recidivism after transplantation. De novo malignancies were a leading cause of late death in ALD patients.\"}]","Long-term outcomes of liver transplantation for alcohol-related liver disease | PDF",1790679625]