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Overall survival at five years was analyzed, with ASA-PS and PNI emerging as independent prognostic factors.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/long-term-outcomes-of-endoscopic-resection-of-superficial-esophageal-squamous-cell-carcinoma-in-late-elderly-patients/332873/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/long-term-outcomes-of-endoscopic-resection-of-superficial-esophageal-squamous-cell-carcinoma-in-late-elderly-patients/332873.png","ImageObject",300,407,{"name":42,"@type":43},"Clementine","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-11-03","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",8,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What was the study’s main purpose?","Question",{"text":63,"@type":64},"To clarify indications for endoscopic resection (ER) in late-elderly patients with superficial ESCC in terms of life expectancy.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"Which factors were evaluated to predict prognosis?",{"text":68,"@type":64},"Clinical status and comorbidity measures were collected at ER, including Eastern Cooperative Oncology Group performance status, ASA-PS, Charlson comorbidity index, and the prognostic nutritional index (PNI).",{"name":70,"@type":61,"acceptedAnswer":71},"What did the multivariate analysis show about prognosis?",{"text":72,"@type":64},"An ASA-PS of 3 and a PNI of \u003C44.0 were independent prognostic factors, with worse overall survival risk.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},332873,1790184101,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,111,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":108,"show_sort_weight":109,"slug":110},7,"Healthcare",40,"healthcare",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":112,"slug":113},30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":55,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":55,"language":139,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":12,"update_tm":143,"read_time":117,"preview_page_count":4},1374391974564,"https://ap-avatar.wpscdn.com/avatar/14000253aa45c000a9e?x-image-process=image/resize,m_fixed,w_180,h_180&k=1779874745381141002","doi:10.1111/jgh.16764  \nORIGINAL ARTICLE - GASTRO ENTER OLOGY (CLINICAL)  \nLong-term outcomes of endoscopic resection of superficial esophageal squamous cell carcinoma in late-elderly patients  \nKatsunori Matsueda, *  Seiji Kawano, * Keisuke Fukui,† Shoichiro Hirata, * Takuya Satomi, * Shoko Inoo, * Kenta Hamada, * Yoshiyasu Kono, * Masaya Iwamuro, *  Yoshiro Kawahara‡ and Motoyuki Otsuka *  \n*Department of Gastroenterology and Hepatology, Okayama University Hospital,‡Department of Practical Gastrointestinal Endoscopy, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama,†Faculty of Societal Safety Sciences, Kansai University, Osaka, Japan  \nKey words  \nendoscopic resection, esophageal cancer, lateelderly patient, long-term outcome.  \nAccepted for publication 24 September 2024 .  \nCorrespondence  \nKatsunori Matsueda, Department of Gastroenterology and Hepatology, Okayama University Hospital, Okayama, 2-5-1 Shikatacho, Kita-Ku, Okayama 700-8558, Japan.  \nEmail: [rge43gs@yahoo.co.jp](rge43gs@yahoo.co.jp)  \nDeclaration of conflict of interest: The authors declare that they have no conflict of interest. Financial support: This study did not receive any funding.  \nAbstract  \nBackground and Aim: As the population ages, the number of elderly patients with superficial esophageal squamous cell carcinoma (ESCC) is increasing. We aimed to clarify the indications for endoscopic resection (ER) in late-elderly patients with ESCC in terms of life expectancy.  \nMethods: Patients aged ≥75 years who underwent ER for ESCC at our institution from January 2005 to December 2018 were enrolled. Clinical data, including the Eastern Cooperative Oncology Group performance status, American Society of Anesthesiologists physical status (ASA-PS), Charlson comorbidity index, and prognostic nutritional index (PNI), were collected at the time of ER. The main outcome measure was overall survival (OS) . Results: Two hundred eight consecutive patients were enrolled. The patients ’ median age was 78 years (range, 75–89 years) . The 5-year follow-up rate was 88.5%(median follow-up period, 6 .6 years) . The 5-year OS rate was 79 .2%(95% confidence interval [CI], 72.2–84.8), and 5-year net survival standardized for age, sex, and calendar year was 1.04 (95% CI, 0.98–1.09) . In the multivariate analysis, an ASA-PS of 3 (hazard ratio, 2.45; 95% CI, 1.16–5.17) and PNI of \u003C44.0 (hazard ratio, 2.73; 95% CI, 1.38–5.40) were independent prognostic factors. When neither of these factors was met, the 5-year OS rate was 87.8%(95% CI, 80.0–92.9), and 5-year net survival was 1.08 (95% CI, 1.02–1.14) . Conclusions: ER for ESCC in late-elderly patients may improve life expectancy. ER is recommended in patients with a good ASA-PS and PNI.  \nIntroduction  \nJapan has one of the largest aging societies worldwide. In 2021, the average life expectancy increased to 81.5 years for men and 87.6 years for women.1 Late-elderly people (age of ≥75 years) accounted for 14.9% of Japan’s total population in 2021, and this figure is expected to reach 25 .6% by 2065 .2 As the population ages, the number of elderly patients with esophageal cancer (EC) is increasing. In Japan, the number of EC-related deaths in late-elderly people increased 1.79 times in 2021 compared with 2001 (from 3300 to 5900) .3  \nAlthough advanced EC is associated with poor survival,4 EC can be cured by endoscopic resection (ER), surgical resection, or chemoradiotherapy if diagnosed at an early stage.5–11 ER, including endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD), is a safer and less invasive procedure that better preserves esophageal function compared with surgical resection or chemoradiotherapy. A favorable prognosis can be expected after ER,6,11 even in elderly patients.12–15 Thus, ER is important for preventing EC-related mortality. However, elderly patients tend to have more comorbidities, a shorter life expectancy, and a poorer general condition than non","cbCais2mw0xmXG6l","https://ap.wps.com/l/cbCais2mw0xmXG6l","pdf",305985,"English","# Background and Aim\n# Methods\n## Study design and setting\n## Participants\n# Results\n# Conclusions\n# Introduction\n# Methods\n## Study protocol and ethics\n## Participants (continued)","[{\"question\":\"What was the study’s main purpose?\",\"answer\":\"To clarify indications for endoscopic resection (ER) in late-elderly patients with superficial ESCC in terms of life expectancy.\"},{\"question\":\"Which factors were evaluated to predict prognosis?\",\"answer\":\"Clinical status and comorbidity measures were collected at ER, including Eastern Cooperative Oncology Group performance status, ASA-PS, Charlson comorbidity index, and the prognostic nutritional index (PNI).\"},{\"question\":\"What did the multivariate analysis show about prognosis?\",\"answer\":\"An ASA-PS of 3 and a PNI of \\u003c44.0 were independent prognostic factors, with worse overall survival risk.\"}]","Long-term outcomes of endoscopic resection of superficial esophageal squamous cell carcinoma in late-elderly patients | PDF",1789999816]