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A multicenter retrospective cohort of 352 patients was analyzed to assess recurrence timing and the emergence of secondary primary tumors (SPTs). Recurrence occurred in 65 patients (18.5%), while 60-month follow-up showed SPT development in 91 patients (25.9%), mainly in the lungs. A new nomogram incorporating age, T- and N-classification, and treatment estimated survival, highlighting that recurrent disease is less frequent yet earlier than SPTs.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/long-term-care-and-follow-up-in-laryngeal-cancer-patients-a-multicenter-retrospective-analysis/376948/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/long-term-care-and-follow-up-in-laryngeal-cancer-patients-a-multicenter-retrospective-analysis/376948.png","ImageObject",300,407,{"name":92,"@type":93},"\tCallum ","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-28","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What was the purpose of this multicenter study?","Question",{"text":112,"@type":113},"To analyze outcomes after surgical treatment of LSCC, focusing on patterns and causes of treatment failures, recurrence, and secondary malignancies, and to build predictors into a survival nomogram.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How many patients experienced recurrence and when?",{"text":117,"@type":113},"Recurrence was observed in 65 patients (18.5%) with a mean time of 16.5 months after treatment.",{"name":119,"@type":110,"acceptedAnswer":120},"What did the study find about secondary primary tumors (SPTs)?",{"text":121,"@type":113},"Within 60 months, 91 patients (25.9%) developed SPTs, most commonly in the lungs, and secondary head and neck cancers occurred about twice as late as lung cancer.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},376948,1790584746,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},137451211410,"https://ap-avatar.wpscdn.com/avatar/2000bb0a9246f588df?x-image-process=image/resize,m_fixed,w_180,h_180&k=1786362646172706240","Article  \nLong-Term Care and Follow-Up in Laryngeal Cancer Patients: A Multicenter Retrospective Analysis  \nBlažen Mariji´c 1,2,3,†, Filip Tudor 2,3,†, Stefan Janik 4, Stefan Grasl 4, Florian Frommlet 5, Diana Marži´c 3,6, Ita Hadžisejdi´c 3,7, Jelena Vukeli´c 3,6, Tamara Braut 2,3, Marko Velepiˇc 2,3 and Boban M. Erovic 1, *  \nCitation: Mariji´c, B.; Tudor, F.; Janik, S.; Grasl, S.; Frommlet, F.; Marži´c, D.; Hadžisejdi´c, I.; Vukeli´c, J.; Braut, T.; Velepiˇc, M.; et al. Long-Term Care and Follow-Up in Laryngeal Cancer Patients: A Multicenter Retrospective Analysis. J. Pers. Med. 2023, 13, 927 .  \n[https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)jpm13060927  \nAcademic Editor: Massimo Mesolella  \nReceived: 14 May 2023  \nRevised: 29 May 2023  \nAccepted: 30 May 2023  \nPublished: 31 May 2023  \nCopyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Institute of Head and Neck Diseases, Evangelical Hospital, 1180 Vienna, Austria; [blazen.marijic@uniri.hr](blazen.marijic@uniri.hr)  \n2 Department of Otorhinolaryngology, Head and Neck Surgery, Clinical Hospital Center Rijeka,  \n51000 Rijeka, Croatia; fi[lip.tudor@medri.uniri.hr](lip.tudor@medri.uniri.hr) (F.T.); [tamara.braut@uniri.hr](tamara.braut@uniri.hr) (T.B.); [marko.velepic@medri.uniri.hr](marko.velepic@medri.uniri.hr) (M.V.)  \n3 Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia; [diana.marzic@uniri.hr](diana.marzic@uniri.hr) (D.M.); [ita.hadzisejdic@uniri.hr](ita.hadzisejdic@uniri.hr) (I.H.); [jelena.vukelic@uniri.hr](jelena.vukelic@uniri.hr) (J.V.)  \n4 Department of Otorhinolaryngology, Head and Neck Surgery, Medical University Vienna, 1090 Vienna, Austria; [stefan.janik@meduniwien.ac.at](stefan.janik@meduniwien.ac.at) (S.J.); [stefan.grasl@meduniwien.ac.at](stefan.grasl@meduniwien.ac.at) (S.G.)  \n5 Center for Medical Statistics, Informatics and Intelligent Systems, Section for Medical Statistics, Medical University Vienna, 1090 Vienna, Austria; fl[orian.frommlet@meduniwien.ac.at](orian.frommlet@meduniwien.ac.at)  \n6 Department of Audiology and Phoniatrics, Clinical Hospital Centre Rijeka, 51000 Rijeka, Croatia  \n7 Clinical Department of Pathology and Cytology, Clinical Hospital Center Rijeka, 51000 Rijeka, Croatia  \n* [Correspondence: b.erovic@ekhwien.at](Correspondence: b.erovic@ekhwien.at); Tel.: +43-699-13356731 † These authors contributed equally to this work.  \nAbstract: Purpose: We conducted an outcome analysis on surgically treated laryngeal squamous cell carcinoma (LSCC) patients. Methods: A multicenter retrospective study with 352 patients was analyzed. A new nomogram that incorporates age, T-and N-classification, and treatment was created. Results: Recurrence was observed in 65 (18.5%) patients after a mean time of 16.5 months. After 60 months, 91 (25.9%) of patients developed secondary primary tumors (SPT), most commonly in the lungs (n = 29; 8.2%) followed by other head and neck cancers (n = 21; 6.0%) . Notably, the mean time to occurrence of secondary head and neck cancers was twice that of lung cancer (101.1 vs. 47.5 months) . Conclusion: Recurrent disease is less common in LSCC patients and appears much earlier than SPT. Because one in every four laryngeal cancer patients develops SPTs within 5–10 years, long-term care and follow-up, including imaging studies, are highly recommended. The nomogram was useful for estimating survival.  \nKeywords: long-term care and follow-up; laryngeal carcinoma; secondary primary tumor; recurrence; survival  \n1. Introduction  \nDespite continuous advances in medicine over the past decades, laryngeal cancer remains one of the most challenging malignancies of the upper respiratory tract ","cbCaioB3uqp4I4Op","https://ap.wps.com/l/cbCaioB3uqp4I4Op","pdf",1150170,13,"English","# Abstract\n# 1. Introduction\n# 2. Materials and Methods\n## 2.1. Study Cohort","[{\"question\":\"What was the purpose of this multicenter study?\",\"answer\":\"To analyze outcomes after surgical treatment of LSCC, focusing on patterns and causes of treatment failures, recurrence, and secondary malignancies, and to build predictors into a survival nomogram.\"},{\"question\":\"How many patients experienced recurrence and when?\",\"answer\":\"Recurrence was observed in 65 patients (18.5%) with a mean time of 16.5 months after treatment.\"},{\"question\":\"What did the study find about secondary primary tumors (SPTs)?\",\"answer\":\"Within 60 months, 91 patients (25.9%) developed SPTs, most commonly in the lungs, and secondary head and neck cancers occurred about twice as late as lung cancer.\"}]","Long-Term Care and Follow-Up in Laryngeal Cancer Patients - A Multicenter Retrospective Analysis | PDF",1790222269,33]