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Enriched TMPO-AS1 in tumor tissues correlates with poor prognosis. TMPO-AS1 knockdown increases SW480 cell apoptosis while suppressing invasion, proliferation, migration, and glucose metabolism. Mechanistically, miR-1270 directly binds TMPO-AS1 and targets PKM2 3’UTR; miR-1270 antagonism reverses these effects. The miR-1270/PKM2 axis links TMPO-AS1 to glycolysis regulation.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/long-noncoding-rna-tmpo-as1-accelerates-glycolysis-by-regulating-the-mir-1270pkm2-axis-in-colorectal-cancer/330142/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/long-noncoding-rna-tmpo-as1-accelerates-glycolysis-by-regulating-the-mir-1270pkm2-axis-in-colorectal-cancer/330142.png","ImageObject",300,407,{"name":92,"@type":93},"Patrick","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What does TMPO-AS1 do in colorectal cancer cells?","Question",{"text":112,"@type":113},"TMPO-AS1 knockdown promotes SW480 cell apoptosis and reduces invasion, proliferation, migration, and glucose metabolism, indicating an oncogenic role.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How is miR-1270 connected to TMPO-AS1 and PKM2?",{"text":117,"@type":113},"MiR-1270 directly binds TMPO-AS1 and also binds the 3’UTR of PKM2, leading to PKM2 downregulation and affecting glycolysis-related behavior.",{"name":119,"@type":110,"acceptedAnswer":120},"How do miR-1270 inhibitors influence the effects of TMPO-AS1 knockdown?",{"text":121,"@type":113},"MiR-1270 inhibitors reverse the suppressive effects of TMPO-AS1 knockdown on tumor cell proliferation, invasion, and glycolysis, supporting pathway causality.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},330142,1790156376,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},549758146520,"https://ap-avatar.wpscdn.com/avatar/80002397d8c0411e94?_k=1775819394049821470","Jin et al. BMC Cancer (2024) 24:238  \n[https://doi.org/10.1186/s12885-024-11964-w](https://doi.org/10.1186/s12885-024-11964-w)  \nBMC Cancer  \n RESEARCH Open Access  \nLong noncoding RNA TMPO-AS1 accelerates   glycolysis by regulating the miR-1270/PKM2 axis in colorectal cancer  \nYingmin Jin1*, Aimin Jiang1, Liying Sun 1 and Yue Lu 1  \nAbstract  \nBackground Long noncoding RNA thymopoietin-antisense RNA 1 (TMPO-AS1) is recognized as a participant in cancer progression. Nevertheless, its biological function in colorectal cancer remains obscure and needs further elucidation.  \nMethods and Results First, we discovered enriched TMPO-AS1 in the tumor tissues that were related to poor prognosis. TMPO-AS1 knockdown enhanced SW480 cell apoptosis but inhibited invasion, proliferation, migration, and glucose metabolism. Further, MiR-1270 is directly bound with TMPO-AS1 . MiR-1270 mimics were confirmed to inhibit cell proliferation, invasion, and glucose metabolism in our study. Mechanistically, miR-1270 directly is bound with the 3’untranslated regions (3’UTR) of PKM2 to downregulate PKM2 . MiR-1270 inhibitors reversed the TMPO-AS1 knockdown’s effect on suppressing the tumor cell proliferation, invasion, and glycolysis, while the knockdown of PKM2 further inverted the function of miR-1270 inhibitors on the TMPO-AS1 knockdown.  \nConclusions This study illustrated that TMPO-AS1 advanced the development and the glycolysis of colorectal cancer by modulating the miR-1270/PKM2 axis, which provided a new insight into the colorectal cancer therapeutic strategy. Keywords Colorectal cancer, TMPO-AS1, miR-1270, PKM2, Glycolysis  \nIntroduction  \nAs the most prevalent gastrointestinal cancer, colorectal cancer has a continuously increasing incidence in young people with poor prognosis [1]. Many pathological and molecular therapies have been explored to serve as clinical interventions for colorectal cancer, which achieved much progress [2, 3]. However, the improvements in survival of colorectal cancer patients are still unsatisfactory [4].  \n*Correspondence: Yingmin Jin [002101@hrbmu.edu.cn](002101@hrbmu.edu.cn)  \n1 Department of Gastroenterology, The First Affiliated Hospital of Harbin Medical University, 23 Youzheng Str, Harbin 150001, People’s Republic of China  \nTumor cells often show intense abilities of proliferation, migration, invasion, anti-apoptosis, angiogenesis, and avoidance of growth inhibition. Recently, it has been found that tumors also can alter energy metabolism, which contributes a lot to helping the cells maintain the malignancy and making the glycolytic signaling pathway another essential feature of cancer [5]. Cancerous cells commonly display glycolytic pathway activation, which keeps the cells in high metabolic status and produces more lactic acid, resulting in decreasing extracellular pH [6]. High levels of glycolysis and low extracellular pH are associated with malignancy, including cancer cell proliferation and invasion, leading to a worse prognosis in colorectal cancer patients [7, 8].  \nLong non-coding RNA (lncRNA), with over 200 nucleotides in length, participates in many physiological and pathological processes, including immune response [9],  \n© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To ","cbCaiqwo3CGmF3xu","https://ap.wps.com/l/cbCaiqwo3CGmF3xu","pdf",5185185,11,"English","# Abstract\n## Background\n## Methods and Results\n## Conclusions\n# Introduction\n# Materials and Methods\n## Specimens\n## Cell culture and tran","[{\"question\":\"What does TMPO-AS1 do in colorectal cancer cells?\",\"answer\":\"TMPO-AS1 knockdown promotes SW480 cell apoptosis and reduces invasion, proliferation, migration, and glucose metabolism, indicating an oncogenic role.\"},{\"question\":\"How is miR-1270 connected to TMPO-AS1 and PKM2?\",\"answer\":\"MiR-1270 directly binds TMPO-AS1 and also binds the 3’UTR of PKM2, leading to PKM2 downregulation and affecting glycolysis-related behavior.\"},{\"question\":\"How do miR-1270 inhibitors influence the effects of TMPO-AS1 knockdown?\",\"answer\":\"MiR-1270 inhibitors reverse the suppressive effects of TMPO-AS1 knockdown on tumor cell proliferation, invasion, and glycolysis, supporting pathway causality.\"}]","Long noncoding RNA TMPO-AS1 accelerates glycolysis by regulating the miR-1270/PKM2 axis in colorectal cancer | PDF",1789987403,28]