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This study investigates lncRNA KTN1-AS1 in GBM tumor progression by examining its expression, biological function, and underlying molecular mechanism. KTN1-AS1 is upregulated in GBM tissues and cell lines and promotes GBM cell proliferation, migration, and invasion. Mechanistically, KTN1-AS1 targets miR-505, reducing its expression, and increases miR-505-related oncogenes including ZEB2, HMGB1, and RUNX2.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/long-non-coding-rna-ktn1-as1-targets-mir-505-to-promote-glioblastoma-progression/385500/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/long-non-coding-rna-ktn1-as1-targets-mir-505-to-promote-glioblastoma-progression/385500.png","ImageObject",300,407,{"name":92,"@type":93},"hdkawk","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-27","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What role does KTN1-AS1 play in glioblastoma progression?","Question",{"text":112,"@type":113},"KTN1-AS1 is upregulated in GBM and promotes malignant behaviors, including proliferation, migration, and invasion of GBM cells.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How does KTN1-AS1 affect miR-505 expression in GBM?",{"text":117,"@type":113},"KTN1-AS1 targets miR-505, and miR-505 expression is decreased in GBM, with KTN1-AS1 contributing to progression through this regulation.",{"name":119,"@type":110,"acceptedAnswer":120},"Which oncogenes are reported to be upregulated downstream of miR-505?",{"text":121,"@type":113},"KTN1-AS1 increases oncogenes associated with miR-505, including ZEB2, HMGB1, and RUNX2, in GBM cells.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},385500,1790318669,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},3985747859855,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","Hindawi  \nBehavioural Neurology  \nVolume 2023, Article ID 4190849, 11 pages [https://doi.org/10.1155/2023/4190849](https://doi.org/10.1155/2023/4190849)  \nResearch Article  \nLong Non-coding RNA KTN1-AS1 Targets miR-505 to Promote Glioblastoma Progression  \nKai Guo , 1 Lingling Fang, 1 Mingjian Li, 1 Aizheng Li, 1 and Na Liu 2  \n1Department of Neurosurgery, Weifang People ’s Hospital, Weifang, Shandong 261000, China  \n2Department of Neurology, Anqiu People ’s Hospital, Anqiu, Shandong 262100, China  \nCorrespondence should be addressed to Na Liu; [liuna830614@126.com](liuna830614@126.com)  \nReceived 24 August 2021; Revised 19 December 2022; Accepted 13 January 2023; Published 31 January 2023  \nAcademic Editor: Muh-Shi Lin  \nCopyright © 2023 Kai Guo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.  \nGlioblastoma (GBM) is a highly malignant cancer, the prognosis of which is pretty poor. Long non-coding RNAs (lncRNAs) are a class of non-coding RNAs, which play important roles in carcinogenesis process of many cancers including GBM. In this study, we want to clarify the expression, biological function, and molecular mechanism of lncRNA KTN1 antisense RNA 1 (KTN1-AS1) in GBM tumor progression. We found that KTN1-AS1 expression was upregulated in GBM tissues and cell lines. KTN1-AS1 played oncogenic roles to facilitate proliferation, migration, and invasion of GBM cells. Then, we revealed that miR-505 was a target of KTN1-AS1, and its expression was decreased in GBM. KTN1-AS1 contributed to GBM progression by mediating miR-505 . Finally, we demonstrated that KTN1-AS1 upregulated some target oncogenes of miR-505 including ZEB2, HMGB1, and RUNX2 in GBM cells. All in all, we concluded that the highly expressed KTN1-AS1 in GBM played oncogenic roles to facilitate GBM progression by targeting miR-505 .  \n1. Introduction  \nGlioma is the most common primary tumor of the central nervous system, and glioblastoma (GBM) is the most malignant subtype of glioma, which is characterized by an unacceptably high invasive potential [1, 2] . Despite advanced therapies such as surgery, chemotherapy, and radiotherapy have been widely applied in the clinical treatment at present, the prognosis of GBM patients remains poor due to the high malignancy [3, 4] . Therefore, it is vital to study the mechanisms underlying the invasive phenotype of GBM and identify novel therapeutic targets to improve prognosis.  \nLong non-coding RNAs (lncRNAs) are a class of noncoding RNAs with more than 200 nucleotides [5] . More and more studies indicate that lncRNAs affect a variety of biological processes and play important roles in carcinogenesis process of many cancers including GBM [6, 7] . LncRNAs are able to play biological roles via multiple mechanisms, and the most common one is the competitive endogenous RNAs (ceRNAs) way. In this way, lncRNAs  \nincrease the expression of microRNAs (miRNAs) target genes by competitively sponging these miRNAs [8, 9] .  \nLncRNA KTN1 antisense RNA 1 (KTN1-AS1) is a newly identified lncRNA, which has already been reported as anoncogenic gene in several malignant tumors [10–12] . However, to our knowledge, the expression, biological function, and molecular mechanism of KTN1-AS1 in GBM remain still unknown. Therefore, in this study, we want to focus on KTN1-AS1 to clarify its roles in GBM tumor progression.  \n2. Materials and Methods  \n2.1. Tissue Samples. Paired GBM tissues and normal paratumor tissues were collected from 40 patients diagnosed with GBM in Weifang People’s Hospital. None of these patients received local or systemic treatment before surgery. This study was approved by the Ethics Committee of Weifang People’s Hospital. All participants enrolled in this study had signed written informed consent.  \n2.2. Cell Culture and Transfection. Human GBM cell lines (A172,","cbCail4vrpsjVahg","https://ap.wps.com/l/cbCail4vrpsjVahg","pdf",2087996,11,"English","# 1. Introduction\n# 2. Materials and Methods\n## 2.1. Tissue Samples\n## 2.2. Cell Culture and Transfection\n## 2.3. RT-qPCR\n## 2.4. Western Blot Assay","[{\"question\":\"What role does KTN1-AS1 play in glioblastoma progression?\",\"answer\":\"KTN1-AS1 is upregulated in GBM and promotes malignant behaviors, including proliferation, migration, and invasion of GBM cells.\"},{\"question\":\"How does KTN1-AS1 affect miR-505 expression in GBM?\",\"answer\":\"KTN1-AS1 targets miR-505, and miR-505 expression is decreased in GBM, with KTN1-AS1 contributing to progression through this regulation.\"},{\"question\":\"Which oncogenes are reported to be upregulated downstream of miR-505?\",\"answer\":\"KTN1-AS1 increases oncogenes associated with miR-505, including ZEB2, HMGB1, and RUNX2, in GBM cells.\"}]","Long non-coding RNA KTN1-AS1 Targets miR-505 to Promote Glioblastoma Progression | PDF",1790269622,28]