[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-330330-105":59,"doc-detail-330330-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","long-intergenic-non-coding-rnas-of-human-chromosome-18-focus-on-cancers","Long Intergenic Non-Coding RNAs of Human Chromosome 18 - Focus on Cancers","","Malignant neoplasms show high molecular heterogeneity driven by multilevel deregulation of gene expression and cellular functions. Long intergenic non-coding RNAs (lincRNAs) are important in cancer biology. This review analyzes genomic, transcriptomic, epigenomic, interactomic, and literature evidence for 65 lincRNAs on human chromosome 18 across pan-cancer studies. The set is grouped into subgroups by direct or indirect cancer involvement, tissue-specific expression, fusion, amplification and deletion frequency, differential expression patterns, and subtype specificity.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/long-intergenic-non-coding-rnas-of-human-chromosome-18-focus-on-cancers/330330/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/long-intergenic-non-coding-rnas-of-human-chromosome-18-focus-on-cancers/330330.png","ImageObject",300,407,{"name":92,"@type":93},"Lucas Martin","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-23","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What are lincRNAs and why are they relevant to cancers in this review?","Question",{"text":112,"@type":113},"LincRNAs are long non-coding transcripts with specific genomic organization, and they can regulate gene expression and other biomolecular functions. This review connects lincRNA dysregulation and interactions to cancer biology across many cancer types.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How many lincRNAs on human chromosome 18 are analyzed, and how are they assessed?",{"text":117,"@type":113},"The review analyzes 65 lincRNAs from human chromosome 18. It integrates genomic, transcriptomic, epigenomic, interactomic, and literature data to evaluate direct or indirect cancer involvement.",{"name":119,"@type":110,"acceptedAnswer":120},"What major molecular characteristics are reported for chromosome 18 lincRNAs in cancers?",{"text":121,"@type":113},"Reported characteristics include tissue-specific expression patterns, known gene fusions, gene amplifications and deletions at notable frequencies, and differential expression across cancer types. The review also describes lincRNA interactomes involving microRNAs and proteins, plus enrichment-linked signaling pathway associations.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},330330,1790874314,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":56,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144,"preview_page_count":4},8796095360427,"https://ap-avatar.wpscdn.com/davatar_994ba38a5ba835b3df7d355c54d3ed8d","biomedicines  \nReview  \nLong Intergenic Non-Coding RNAs of Human Chromosome 18: Focus on Cancers  \nPavel V. Ershov *, Evgeniy O. Yablokov , Yuri V. Mezentsev  and Alexis S. Ivanov   \nCitation: Ershov, P.V.; Yablokov, E.O.; Mezentsev, Y.V.; Ivanov, A.S. Long Intergenic Non-Coding RNAs of Human Chromosome 18: Focus on Cancers. Biomedicines 2024, 12, 544 . [https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)biomedicines12030544  \nAcademic Editor: Georgia Levidou  \nReceived: 12 January 2024  \nRevised: 22 February 2024  \nAccepted: 23 February 2024  \nPublished: 28 February 2024  \nCopyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \nInstitute of Biomedical Chemistry, Moscow 119121, Russia; [evgeniy.yablokov@ibmc.msk.ru](evgeniy.yablokov@ibmc.msk.ru) (E.O.Y.);  \n[yu.mezentsev@gmail.com](yu.mezentsev@gmail.com) (Y.V.M.); [alexei.ivanov@ibmc.msk.ru](alexei.ivanov@ibmc.msk.ru) (A.S.I.)  \n* [Correspondence: pavel79@inbox.ru](Correspondence: pavel79@inbox.ru)  \nAbstract: Malignant neoplasms are characterized by high molecular heterogeneity due to multilevel deregulation of gene expression and cellular functions. It is known that non-coding RNAs, including long intergenic non-coding RNAs (lincRNAs), can play significant roles in cancer biology. The current review focuses on a systematical analysis of genomic, transcriptomic, epigenomic, interactomic, and literature data on 65 lincRNAs of human chromosome 18 in the context of pan-cancer studies. The entire group of lincRNAs can be conditionally divided into 4 subgroups depending on experimental evidence on direct or indirect involvement in cancers and the biological associations with cancers, which we found during the data-mining process: the most studied (5 lincRNAs), moderately or poorly studied (11 lincRNAs), and understudied (31 lincRNAs) . For the remaining 18 lincRNAs, data for analysis were fragmentary or missing. Among the key findings were the following: Of the lincRNAs of human chromosome 18, 40% have tissue-specific expression patterns, 22% of lincRNAsare known to have gene fusions, 40% of lincRNAs are prone to gene amplifications and/or deletionsin cancers at a frequency greater than 3%, and 23% of lincRNAs are differentially expressed across cancer types, whereas 7% have subtype-specific expression patterns. LincRNAs’ interactomes consist of ‘master’ microRNAs and 47 proteins (including cancer-associated proteins and microRNAs) that can interact with 3 or more lincRNAs. Functional enrichment analysis of a set of highly co-expressed genes retrieved for 17 lincRNAs in different cancer types indicated the potential associations of these lincRNAs with cellular signaling pathways. Six lincRNAs encoded small open-reading frame (smORF) proteins with emerging roles in cancers, and microRNAs as well as proteins with known functions in molecular carcinogenesis can bind to coding regions of smORFs. We identified seven transcriptomic signatures with potential prognostic value, consisting of two to seven different lincRNAs only. Taken together, the literature, biomedical, and molecular biology data analyzed indicated that only five of all lincRNAs of human chromosome 18 are cancer-associated, while eleven other lincRNAs have the tendency to be associated with cancers.  \nKeywords: chromosome 18; open-reading frame; cancers; non-coding RNA; long-intergenic non-coding RNA; RNA–RNA interactions; RNA–protein interactions; transcriptomic signatures  \n1. Introduction  \nLong non-coding RNAs (lncRNAs) have been arbitrarily defined as non-coding transcripts of more than 200 nucleotides (200 nt) [1], but today, the term ‘lncRNA’ defines amore expanded list of different RNA","cbCaidUgkMZyHC6t","https://ap.wps.com/l/cbCaidUgkMZyHC6t","pdf",2680508,"English","# Introduction\n# Review focus and lincRNA characterization\n## Pan-cancer genomic and transcriptomic evidence\n## Epigenomic and interactomic associations\n## Transcriptomic signatures and prognostic potential\n# Key findings and conclusions","[{\"question\":\"What are lincRNAs and why are they relevant to cancers in this review?\",\"answer\":\"LincRNAs are long non-coding transcripts with specific genomic organization, and they can regulate gene expression and other biomolecular functions. This review connects lincRNA dysregulation and interactions to cancer biology across many cancer types.\"},{\"question\":\"How many lincRNAs on human chromosome 18 are analyzed, and how are they assessed?\",\"answer\":\"The review analyzes 65 lincRNAs from human chromosome 18. It integrates genomic, transcriptomic, epigenomic, interactomic, and literature data to evaluate direct or indirect cancer involvement.\"},{\"question\":\"What major molecular characteristics are reported for chromosome 18 lincRNAs in cancers?\",\"answer\":\"Reported characteristics include tissue-specific expression patterns, known gene fusions, gene amplifications and deletions at notable frequencies, and differential expression across cancer types. The review also describes lincRNA interactomes involving microRNAs and proteins, plus enrichment-linked signaling pathway associations.\"}]","Long Intergenic Non-Coding RNAs of Human Chromosome 18 - Focus on Cancers | PDF",1789988198,48]