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This study defines MIR155HG biological functions and mechanisms in gastric cancer (GC) cells. MIR155HG expression is markedly elevated in GC patients’ serum, and it enhances malignant phenotypes including proliferation, colony formation, migration, and tumor growth in nude mice. NF-κB and STAT3 pathways are implicated; inhibiting them reduces MIR155HG-driven effects.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/lncrna-mir155hg-overexpression-promotes-proliferation-migration-and-chemoresistance-in-gastric-cancer-cells/383718/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/lncrna-mir155hg-overexpression-promotes-proliferation-migration-and-chemoresistance-in-gastric-cancer-cells/383718.png","ImageObject",300,407,{"name":92,"@type":93},"Mia  ","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-26","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":8},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the main finding about MIR155HG in gastric cancer?","Question",{"text":112,"@type":113},"MIR155HG overexpression promotes proliferation, migration, and chemoresistance in gastric cancer cells, accompanied by increased expression in patient serum.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How do NF-κB and STAT3 relate to MIR155HG’s effects?",{"text":117,"@type":113},"The study suggests NF-κB and STAT3 signaling pathways are involved in regulating MIR155HG-driven malignant behavior, and blocking these pathways attenuates the phenotypes.",{"name":119,"@type":110,"acceptedAnswer":120},"How does MIR155HG affect treatment response in GC cells?",{"text":121,"@type":113},"Overexpression of MIR155HG reduces apoptosis of gastric cancer cells induced by cisplatin and 5-FU, indicating enhanced chemoresistance.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},383718,1790459293,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":8,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":52,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},687207024478,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","Ivyspring  \nInternational Publisher  \nInternationalJournal of Medical Sciences  \n2023; 20(7): 933-942. doi: 10.7150/ijms.82216  \nResearch Paper  \nLncRNA MIR155HG Overexpression Promotes Proliferation, Migration, and Chemoresistance in Gastric Cancer Cells  \nHong Lin1, Ruoxuan Ni1, Dongdong Li1, Mei Zhao1, Yan Li1, Kexin Li1, Qiao Zhang1, Changzhi Huang1􀀍, Shengkai Huang2􀀍  \n1. Department of Etiology and Carcinogenesis, State Key Laboratory of Molecular Oncology, Beijing Key Laboratory for Carcinogenesis and Cancer Prevention, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, P. R. China.  \n2. Department of Clinical Laboratory, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, P. R. China.  \n􀀍 Corresponding authors: Changzhi Huang, Department of Etiology and Carcinogenesis, State Key Laboratory of Molecular Oncology, Beijing Key Laboratory for Carcinogenesis and Cancer Prevention, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 17 Pan jia yuan Nan li, Chao yang District, Beijing, 100021, [P. R. China. E-mail: huangcz@cicams.ac.cn](P. R. China. E-mail: huangcz@cicams.ac.cn). Shengkai Huang, Department of Clinical Laboratory, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 17 Pan jia yuan Nan li, Chao yang District, Beijing, 100021, P. R. China. E-mail: [huang1988@cicams.ac.cn](huang1988@cicams.ac.cn)  \n© The author(s). This is an open access article distributed under the terms of the Creative Commons Attribution License ([https://creativecommons.org/licenses/by/4.0/](https://creativecommons.org/licenses/by/4.0/)). See [http://ivyspring.com/terms](http://ivyspring.com/terms) for full terms and conditions.  \nReceived: 2022.12.28; Accepted: 2023.04.14; Published: 2023.05.12  \nAbstract  \nLong non-coding RNAs are thought to play a vital role in a variety of human malignancies. Studies have shown that MIR155 host gene (MIR155HG) acts as an oncogene in several cancers, but the function and its mechanism of MIR155HG in gastric cancer (GC) is still poorly understood. In this study, we determined the biological functions and underlying mechanisms of MIR155HG in GC cells. We found that expression levels of MIR155HG was increased markedly in GC patients’ serum. In vitro and in vivo studies demonstrated that MIR155HG modulated the malignant phenotype of GC cells, such as cell proliferation, colony forming ability, cell migration ability, and tumor growth in nude mice. Next, our results revealed that NF-κB and STAT3 signaling pathways could be involved in regulating the malignant behavior of GC cells. Our rescue experiments showed that inhibiting NF-κB and STAT3 signaling pathways attenuated the phenotypes caused by MIR155HG overexpression. Moreover, cytotoxicity and apoptosis assays revealed overexpression of MIR155HG reduced the apotosis of GC cells induced by cisplatin and 5-FU. Together, our studies suggested that MIR155HG overexpression promoted proliferation, migration, and chemoresistance of GC cells. These results might provide a lncRNA-based target for GC treatment in future.  \nKeywords: gastric cancer, MIR155HG, NF-κB, STAT3, chemoresistance  \nIntroduction  \nGastric cancer (GC) is the most aggressive gastrointestinal carcinoma and is characterized by high rate of metastasis and poor prognosis. GC is the fifth most common cancer and the fourth leading cause of death among cancer patients, there were over 1,000,000 new cases and over 760,000 deaths worldwide in 2020 [1] . In China, among all cancers, GC-related incidences and mortalities both rank third. In 2016, nearly 396,500 new inci","cbCaieOEJBmGfzux","https://ap.wps.com/l/cbCaieOEJBmGfzux","pdf",5313439,"English","# Abstract\n# Keywords\n# Introduction","[{\"question\":\"What is the main finding about MIR155HG in gastric cancer?\",\"answer\":\"MIR155HG overexpression promotes proliferation, migration, and chemoresistance in gastric cancer cells, accompanied by increased expression in patient serum.\"},{\"question\":\"How do NF-κB and STAT3 relate to MIR155HG’s effects?\",\"answer\":\"The study suggests NF-κB and STAT3 signaling pathways are involved in regulating MIR155HG-driven malignant behavior, and blocking these pathways attenuates the phenotypes.\"},{\"question\":\"How does MIR155HG affect treatment response in GC cells?\",\"answer\":\"Overexpression of MIR155HG reduces apoptosis of gastric cancer cells induced by cisplatin and 5-FU, indicating enhanced chemoresistance.\"}]","LncRNA MIR155HG Overexpression Promotes Proliferation, Migration, and Chemoresistance in Gastric Cancer Cells | PDF",1790258886,25]