[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-328542-105":59,"doc-detail-328542-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","lncrna-encoded-peptides-in-cancer-review-open-access","LncRNA-encoded peptides in cancer - Review open access","","Long non-coding RNAs (lncRNAs) have become recognized as key regulators of gene expression and important contributors to cancer biology. Evidence shows that specific lncRNAs can encode peptides derived from small open reading frames (sORFs), helping drive tumor development. This review consolidates current knowledge on how sORFs are detected and validated, including ribosome profiling and mass spectrometry, and explains peptide functions in transcription, translation control, signal transduction, and metabolic reprogramming. It also evaluates clinical promise for diagnosis, prognosis, and therapy, while addressing challenges such as large-scale validation and improved detection and delivery.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/lncrna-encoded-peptides-in-cancer-review-open-access/328542/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/lncrna-encoded-peptides-in-cancer-review-open-access/328542.png","ImageObject",300,407,{"name":92,"@type":93},"Ezra","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-23","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":24},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What are lncRNA-encoded peptides and why are they important in cancer?","Question",{"text":112,"@type":113},"Some lncRNAs can encode peptides derived from small open reading frames (sORFs). These peptides participate in cancer pathogenesis and can act as oncogenic drivers or tumor suppressors.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How are sORFs and lncRNA-encoded peptides detected and validated?",{"text":117,"@type":113},"The review highlights technological approaches including ribosome profiling and mass spectrometry, which support the discovery and validation of peptide products from sORFs.",{"name":119,"@type":110,"acceptedAnswer":120},"What cancer-related processes do lncRNA-encoded peptides influence?",{"text":121,"@type":113},"The peptides are linked to multiple processes, including gene transcription, translation regulation, signal transduction, and metabolic reprogramming across different cancer types.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},328542,1790151619,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":24,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},1099514068035,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","Zhang Journal of Hematology & Oncology (2024) 17:66 [https://doi.org/10.1186/s13045-024-01591-0](https://doi.org/10.1186/s13045-024-01591-0)  \nJournal of Hematology & Oncology  \n REVIEW Open Access  \nLncRNA-encoded  \nYaguang Zhang1*  \npeptides  \nin cancer  \nAbstract  \nLong non-coding RNAs (lncRNAs), once considered transcriptional noise, have emerged as critical regulators of gene expression and key players in cancer biology. Recent breakthroughs have revealed that certain lncRNAs can encode small open reading frame (sORF)-derived peptides, which are now understood to contribute to the pathogenesis of various cancers. This review synthesizes current knowledge on the detection, functional roles, and clinical implications of lncRNA-encoded peptides in cancer. We discuss technological advancements in the detection and validation of sORFs, including ribosome profiling and mass spectrometry, which have facilitated the discovery of these peptides. The functional roles of lncRNA-encoded peptides in cancer processes such as gene transcription, translation regulation, signal transduction, and metabolic reprogramming are explored in various types of cancer. The clinical potential of these peptides is highlighted, with a focus on their utility as diagnostic biomarkers, prognostic indicators, and therapeutic targets. The challenges and future directions in translating these findings into clinical practice are also discussed, including the need for large-scale validation, development of sensitive detection methods, and optimization of peptide stability and delivery.  \nKeywords Long non-coding RNA, Small open reading frame, Peptide, Cancer, Application  \nIntroduction  \nLong non-coding RNAs (lncRNAs) were initially defined as a class of RNAs longer than 200 nucleotides that do not encode proteins [1–3]. Initially regarded as \"noise\"from genome transcription, lncRNAs have increasingly been shown to play important roles in the regulation of gene expression at the epigenetic, transcriptional, and post-transcriptional levels [4–8]. They have also been found to be intimately linked with the occurrence and progression of a spectrum of human diseases, with a particularly significant association observed in the context of cancer [9–16].  \nWith the advancement of proteomics and translation technologies, it has been discovered that some lncRNAs  \n*Correspondence:  \nYaguang Zhang [zhangyaguang20085155@126.com](zhangyaguang20085155@126.com)  \n1 Laboratory of Gastrointestinal Tumor Epigenetics and Genomics, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, People’s Republic of China  \nhave the ability to encode small peptides or micropeptides [17–21]. These peptides are encoded by small or short open reading frames (sORFs) and can range in length from tens to over a hundred amino acids (aa) [22– 25]. Furthermore, there is growing evidence that peptides derived from lncRNAs have specific biological functions and can act as oncogenic drivers or tumor suppressors [26–29]. They play important roles in various cancer processes, such as transcriptional regulation, post-transcriptional regulation, translation and post-translational regulation, signal transduction, and cancer metabolism [8, 30–34].  \nDespite numerous reviews on lncRNA-encoded peptides published in the past, most are outdated as they were released several years ago [26, 35, 36]. LncRNAencoded peptides have emerged as a hot topic in recent years, with many new discoveries identifying novel lncRNAs that encode for peptides and their significant functions in cancer, along with new regulatory mechanisms. In this review, we review the methods for detecting lncRNA-encoded peptides, comparing their differences. Additionally, we systematically summarize the lncRNAs  \n© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any n","cbCaihd5oTA2VP3V","https://ap.wps.com/l/cbCaihd5oTA2VP3V","pdf",3176446,33,"English","# Abstract\n# Introduction\n# Biogenesis and detection of lncRNA‑encoded peptides\n## Biogenesis of lncRNA‑encoded peptides","[{\"question\":\"What are lncRNA-encoded peptides and why are they important in cancer?\",\"answer\":\"Some lncRNAs can encode peptides derived from small open reading frames (sORFs). These peptides participate in cancer pathogenesis and can act as oncogenic drivers or tumor suppressors.\"},{\"question\":\"How are sORFs and lncRNA-encoded peptides detected and validated?\",\"answer\":\"The review highlights technological approaches including ribosome profiling and mass spectrometry, which support the discovery and validation of peptide products from sORFs.\"},{\"question\":\"What cancer-related processes do lncRNA-encoded peptides influence?\",\"answer\":\"The peptides are linked to multiple processes, including gene transcription, translation regulation, signal transduction, and metabolic reprogramming across different cancer types.\"}]","LncRNA-encoded peptides in cancer - Review open access | PDF",1789980119,83]