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This study explored patients’ perceptions and lived experience, focusing on symptoms, symptom impact, treatment outcomes, knowledge needs, and potential progression to IA. Semi-structured interviews were analyzed using reflexive thematic analysis, including patient research partners in schedule co-production and coding decisions.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/living-with-palindromic-rheumatism-a-qualitative-interview-study/416688/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/living-with-palindromic-rheumatism-a-qualitative-interview-study/416688.png","ImageObject",300,407,{"name":92,"@type":93},"Anna Hans","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What was the study’s main purpose regarding palindromic rheumatism?","Question",{"text":112,"@type":113},"To explore patients’ perceptions and experiences of living with palindromic rheumatism, including symptoms, impact, treatment outcomes, and potential progression to inflammatory arthritis.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were participants recruited and how were interviews analyzed?",{"text":117,"@type":113},"Patients were recruited from ongoing cohort studies of individuals at risk of developing inflammatory arthritis. Semi-structured interviews were conducted at two UK sites and analyzed using reflexive thematic analysis with patient research partners contributing to the interview schedule and coding decisions.",{"name":119,"@type":110,"acceptedAnswer":120},"What impacts and concerns did patients most commonly report?",{"text":121,"@type":113},"Patients described severe, unpredictable symptoms affecting daily activities and causing psychological distress, with frequent referral delays. Many also reported a lack of information about PR and concerns about taking medication due to side effects.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},416688,1790789911,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":44,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144,"preview_page_count":4},5909892332657,"https://ap-avatar.wpscdn.com/davatar_994ba38a5ba835b3df7d355c54d3ed8d","Clinical science  \nLiving with palindromic rheumatism: a qualitative interview study  \nLara S. Chapman 1 , Zahira P. Latif2, Rebecca J. Stack3, Anne-Maree Keenan4,5, Hanna Gul1,  \nPaul Emery 1,5, Kulveer Mankia1,5, Karim Raza6, Heidi J. Siddle 1, 􀀃 1 Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK 2 UCL Consultants Ltd, University College London, London, UK  \n3Three Counties Medical School, University of Worcester, Worcester, UK 4School of Healthcare, University of Leeds, Leeds, UK  \n5 NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, UK  \n6 Department of Rheumatology, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK  \n􀀃 Correspondence to: Heidi J. Siddle, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, 2nd Floor, Chapel Allerton Hospital,  \nChapeltown Road, Leeds LS7 4SA, UK. E-mail: [h.siddle@leeds.ac.uk](h.siddle@leeds.ac.uk)  \nAbstract  \nObjectives: Palindromic rheumatism (PR) is an unpredictable and under-researched inflammatory condition, and patients with PR are at risk of developing inflammatory arthritis (IA) . This study aimed to explore patients’ perceptions and experiences of living with PR, including symptoms, impact, treatment outcomes and potential progression to IA.  \nMethods: Patients were recruited from ongoing cohort studies identifying individuals at risk of developing IA. Semi-structured interviews were conducted at two UK sites. Data were analysed using reflexive thematic analysis. Patient research partners co-produced the interview schedule and contributed to coding decisions.  \nResults: Eight patients were interviewed. Three themes (seven subthemes) were identified: experiencing symptoms (symptoms, perceptions of triggers, referral experiences); impact of symptoms (activity limitations, psychological impact); treatment expectations and knowledge seeking (treatment outcomes and progression, information and support needs) . Symptom severity was likened to that associated with severe physical injury, and PR impacted on daily activities and caused psychological distress, but referral delays were frequently reported. Patients expressed concerns about taking medication for PR, primarily due to side effects. Most highlighted a lack of information about PR (e.g. medication options and self-management advice) but varied in how much they wanted to understand about PR progression and treatment options.  \nConclusion: This study captured valuable insights into the perceptions and experiences of PR, from the perspective of patients. Findings highlight the severity of symptoms and impact of the condition. Further work to standardize classification criteria and outcome measurement in PR is critical to facilitate meaningful clinical trials in this area.  \nLay Summary  \nWhat does this mean for patients?  \nPeople with palindromic rheumatism (PR) experience unpredictable flares of pain and joint swelling. In between flares, they typically do not have any symptoms, and their blood tests and scans do not show that there is anything wrong. In some cases, PR can progress to RA. We interviewed eight people with PR to understand more about their experiences of living with this condition. People with PR likened their symptoms to severe physical injury. The condition impacted on daily activities and caused psychological distress. Referral delays were common. Some people with PR expressed concerns about taking medication for their condition, due to side effects. They also felt there was a lack of information about PR, including information about medication options and how to self-manage their condition. People with PR had different opinions on how much they wanted to learn about their risk of developing RA in the future. More research is needed to understand how best to treat and support people with PR.  \nKeywords: palindromic rheumatism, patient perspectives, at-risk, RA, qualitative, interviews, ","cbCaihMtyjRCr3j2","https://ap.wps.com/l/cbCaihMtyjRCr3j2","pdf",670909,"English","# Abstract\n# Lay Summary\n# Key messages\n# Introduction","[{\"question\":\"What was the study’s main purpose regarding palindromic rheumatism?\",\"answer\":\"To explore patients’ perceptions and experiences of living with palindromic rheumatism, including symptoms, impact, treatment outcomes, and potential progression to inflammatory arthritis.\"},{\"question\":\"How were participants recruited and how were interviews analyzed?\",\"answer\":\"Patients were recruited from ongoing cohort studies of individuals at risk of developing inflammatory arthritis. Semi-structured interviews were conducted at two UK sites and analyzed using reflexive thematic analysis with patient research partners contributing to the interview schedule and coding decisions.\"},{\"question\":\"What impacts and concerns did patients most commonly report?\",\"answer\":\"Patients described severe, unpredictable symptoms affecting daily activities and causing psychological distress, with frequent referral delays. Many also reported a lack of information about PR and concerns about taking medication due to side effects.\"}]","Living with palindromic rheumatism - a qualitative interview study | PDF",1790606369,23]